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FA2H

  • Official Full Name

    fatty acid 2-hydroxylase

  • Overview

    This gene encodes a protein that catalyzes the synthesis of 2-hydroxysphingolipids, a subset of sphingolipids that contain 2-hydroxy fatty acids. Sphingolipids play roles in many cellular processes and their structural diversity arises from modification of the hydrophobic ceramide moiety, such as by 2-hydroxylation of the N-acyl chain, and the existence of many different head groups. Mutations in this gene have been associated with leukodystrophy dysmyelinating with spastic paraparesis with or without dystonia.
  • Synonyms

    FA2H; fatty acid 2-hydroxylase; fatty acid hydroxylase domain containing 1 , FAXDC1, spastic paraplegia 35 (autosomal recessive) , SPG35; FAAH; fatty acid hydroxylase; FLJ25287; FA2H_HUMAN; FAH1; Fatty acid 2 hydroxylase; Fatty acid alpha hydroxylase; Fatty acid alpha-hydroxylase; Fatty acid hydroxylase domain containing 1; FAXDC1; SCS7; spastic paraplegia 35 (autosomal recessive); SPG35;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FA2H-893H Recombinant Human FA2H, GST-tagged Wheat Germ GST
Human FA2H-12628H Recombinant Human FA2H, His-tagged E.coli His 1-164a.a.
Human FA2H-891H Recombinant Human FA2H, MYC/DDK-tagged HEK293 Myc/DDK
Human FA2H-6481HCL Recombinant Human FA2H 293 Cell Lysate HEK293 N/A
Human FA2H-6921HF Recombinant Full Length Human FA2H Protein, GST-tagged In Vitro Cell Free System GST 372 amino acids
Human FA2H-1254H Recombinant Human FA2H Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse FA2H-5419M Recombinant Mouse FA2H Protein Mammalian Cell His
Mouse FA2H-2923M-B Recombinant Mouse FA2H Protein Pre-coupled Magnetic Beads HEK293
Mouse Fa2h-2901M Recombinant Mouse Fa2h Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse FA2H-2923M Recombinant Mouse FA2H Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FA2H-2182R Recombinant Rat FA2H Protein Mammalian Cell His
Rat FA2H-1839R-B Recombinant Rat FA2H Protein Pre-coupled Magnetic Beads HEK293
Rat FA2H-1839R Recombinant Rat FA2H Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey FA2H-501C Recombinant Cynomolgus FA2H Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey FA2H-246C-B Recombinant Cynomolgus Monkey FA2H Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey FA2H-246C Recombinant Cynomolgus Monkey FA2H Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL6729HF Recombinant Full Length Human Fatty Acid 2-Hydroxylase(Fa2H) Protein, His-Tagged E.coli expression system His Full Length (1-372)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL8392MF Recombinant Full Length Macaca Fascicularis Fatty Acid 2-Hydroxylase(Fa2H) Protein, His-Tagged E.coli expression system His Full Length (1-372)
Mus musculus (Mouse) RFL16637MF Recombinant Full Length Mouse Fatty Acid 2-Hydroxylase(Fa2H) Protein, His-Tagged E.coli expression system His Full Length (1-372)
Rattus norvegicus (Rat) RFL14325RF Recombinant Full Length Rat Fatty Acid 2-Hydroxylase(Fa2H) Protein, His-Tagged E.coli expression system His Full Length (1-372)
Rhesus Macaque FA2H-1534R Recombinant Rhesus monkey FA2H Protein, His-tagged Mammalian Cell His
Rhesus Macaque FA2H-1359R-B Recombinant Rhesus Macaque FA2H Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FA2H-1359R Recombinant Rhesus Macaque FA2H Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish FA2H-4375Z Recombinant Zebrafish FA2H Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FA2H Related Articles

FA2H involved in several pathways and played different roles in them. We selected most pathways FA2H participated on our site, such as Metabolism, Metabolism of lipids and lipoproteins, Sphingolipid de novo biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FA2H were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MetabolismTM9SF1;NDUFAF4;CYP2D6;SLC23A2;CPTP;SLC25A2;IVD;CKB;APOEB
Metabolism of lipids and lipoproteinsFAAH2B;CPT2;MED23;CYP2Y3;CERS4A;GPAT2;CDK19;COQ6;APOA5
Sphingolipid de novo biosynthesisVAPB;OSBP;SPTLC1;CERS3B;GDF1;CERS5;PPM1L;ACER1;CERS4A
Sphingolipid metabolismSPTLC2;NEU1;GBA2;ARSD;ACER3;GLTPD1;SPTLC3;UGT8A;SGPL1
fatty acid alpha-oxidation III

FA2H has several biochemical functions, for example, fatty acid alpha-hydroxylase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FA2H itself. We selected most functions FA2H had, and list some proteins which have the same functions with FA2H. You can find most of the proteins on our site.

Function Related Protein
fatty acid alpha-hydroxylase activity
heme bindingCYP4A12A;LPO;CBSB;FAM84B;HBB-BH1;HRG;CYP26C1;CYB5D2;PXDN
iron ion bindingHBBE3;CYP2V1;CYP2P6;HBD;P4HTM;CYP2AA7;LTF;AOX3;SC5D

FA2H has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FA2H here. Most of them are supplied by our site. Hope this information will be useful for your research of FA2H.

Pedroso, JL; Handfas, BW; et al. Fatty acid 2-hydroxylase deficiency Clinical features and brain iron accumulation. NEUROLOGY 84:960-961(2015).
Liao, X; Luo, Y; et al. SPG35 contributes to the second common subtype of AR-HSP in China: frequency analysis and functional characterization of FA2H gene mutations. CLINICAL GENETICS 87:85-89(2015).
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