FCRL2

Official Full Name

Fc receptor-like 2
Overview

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Synonyms

FCRL2; Fc receptor-like 2; SH2 domain containing phosphatase anchor protein 1 , SPAP1; Fc receptor-like protein 2; CD307b; FCRH2; IRTA4; fcR-like protein 2; IFGP family protein 4; fc receptor homolog 2; immunoglobulin superfamily Fc receptor, gp42; SH2 do;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus monkey

Source

HEK293
HEK293T
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

Fc
GST
hIgG4
His
Avi
Myc
DDK
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FCRL2-497H	Active Recombinant Human Fc Receptor-Like 2, His-tagged	Mammalian cells	His		Inquiry
Human	FCRL2-750H	Recombinant Human FCRL2 Protein, His-tagged	HEK293	His	Met1-Asp395	Inquiry
Human	FCRL2-4008H	Recombinant Human FCRL2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FCRL2-6275HCL	Recombinant Human FCRL2 293 Cell Lysate	HEK293	Non		Inquiry
Human	FCRL2-5654H	Recombinant Human FCRL2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	FCRL2-2938H	Recombinant Human FCRL2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	FCRL2-2938H-B	Recombinant Human FCRL2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Fcrl2-5495M	Recombinant Mouse Fcrl2 Protein (Asn18-Phe509), C-Fc tagged	Mammalian cells	Fc	Asn18-Phe509	Inquiry
Rhesus monkey	FCRL2-1713R	Recombinant Rhesus Monkey FCRL2 Protein, hIgG1-tagged	HEK293	Fc	20-399	Inquiry
Rhesus monkey	FCRL2-1712R	Recombinant Rhesus Monkey FCRL2 Protein	HEK293	Non	20-399	Inquiry
Rhesus monkey	FCRL2-1714R	Recombinant Rhesus Monkey FCRL2 Protein, hIgG4-tagged	HEK293	hIgG4	20-399	Inquiry
Chicken	FCRL2-3690C	Recombinant Chicken FCRL2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

FCRL2 involved in several pathways and played different roles in them. We selected most pathways FCRL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FCRL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

FCRL2 has several biochemical functions, for example, SH3/SH2 adaptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCRL2 itself. We selected most functions FCRL2 had, and list some proteins which have the same functions with FCRL2. You can find most of the proteins on our site.

Function	Related Protein
SH3/SH2 adaptor activity	SH3BP2;SH2B2;SKAP2;SH2D1A;IRS4;SH3BGRL;NCK2;SH2D2A;GAB1
protein binding	ATF7;PARVG;S100A12;ECE2;STAM2;SLC19A2;DVL1;LDHAL6B;PTPRD

FCRL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCRL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FCRL2.

NCK2

Research Area

B Cell Receptor-Associated Proteins

Shabani, M; Bayat, AA; et al. Ligation of human Fc receptor like-2 by monoclonal antibodies down-regulates B-cell receptor-mediated signalling. IMMUNOLOGY 143:341-353(2014).

Disanto, G; Sandve, GK; et al. DNase hypersensitive sites and association with multiple sclerosis. HUMAN MOLECULAR GENETICS 23:942-948(2014).