Active Recombinant Human Fc Receptor-Like 2, His-tagged

• Cat.No.: FCRL2-497H
• Product Overview: Recombinant Human FCRL2is expressed in Murine myeloma cell line, which has a molecule weight of 41.9kDa. Leu20 ­ Asp395, with a C­terminal 6­His tag.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: His
• Description: Fc receptor­like 2 (FCRL2),also known as FcRH2 and IRTA4, belongs to the family of glycoprotein homologsof classical immunoglobulin (Ig) Fc receptors. In human, the type I transmembraneFCRL protein family contains from three to nine immunoglobulin­like domains. Maturehuman FcRH2 consists of a 382 amino acid (aa) extracellular domain (ECD) withfour Ig­like C2­set domains, a 21 aa transmembrane segment, and an 86 aa cytoplasmicdomain with one ITAM­like, and two ITIM­like motifs. FCRL proteins are differentiallyexpressed among B cells. FCRL2 is preferentially expressed on naïve and CD27+memory B cells within the spleen, lymph nodes, tonsils, and peripheral blood.It is also expressed on most B cells in B cell chronic lymphocytic leukemia (B­CLL)patients. FCRL2 upregulation is associated with mutation of the immunoglobulinheavy chain variable (IGHV) and less aggressive forms of B­CLL.
• Form: Lyophilized from a 0.2μm filtered solution in PBS.
• N-terminal Sequence: Leu20
• Molecular Weight: 41.9 kDa
• Activity: Measured by its abilityto bind human IgG with an estimated KD < 80 nM.
• Purity: >95%, by SDS-PAGEunder reducing conditions and visualized by silver stain.
• Endotoxin Level: <1.0 EU per 1 μg ofthe protein by the LAL method.
• Reconstitution: Reconstitute at 100 μg/mLin sterile PBS.
• Storage: Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
• OfficialSymbol: FCRL2

Gene Information

• Gene Name: FCRL2 Fc receptor-like 2 [ Homosapiens ]
• Synonyms: FCRL2; Fc receptor-like2; FCRH2; IFGP4; IRTA4; SPAP1; CD307b; SPAP1A; SPAP1B; SPAP1C; CD307b antigen;Fc receptor-like protein 2; fcR-like protein 2; IFGP family protein 4; fc receptorhomolog 2; immunoglobulin superfamily Fc receptor, gp42; SH2 domain containingphosphatase anchor protein 1; SH2 domain-containing phosphatase anchor protein1; immune receptor translocation-associated protein 4; immunoglobulin receptortranslocation-associated protein 4; OTTHUMP00000020928; OTTHUMP00000020931
• Gene ID: 79368
• mRNA Refseq: NM_030764
• Protein Refseq: NP_110391
• MIM: 606509
• UniProt ID: Q96LA5
• Chromosome Location: 1q21
• Function: SH3/SH2 adaptor activity;receptor activity