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FDFT1

  • Official Full Name

    farnesyl-diphosphate farnesyltransferase 1

  • Overview

    This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.
  • Synonyms

    FDFT1; farnesyl-diphosphate farnesyltransferase 1; squalene synthase; squalene synthetase; FPP:FPP farnesyltransferase; presqualene-di-diphosphate synthase; SS; SQS; DGPT; ERG9;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FDFT1-27574TH Recombinant Human FDFT1 Wheat Germ N/A 417 amino acids
Human FDFT1-1829H Recombinant Human FDFT1 protein, His-tagged E.coli His His269~His417 (Accession # P37268)
Human FDFT1-6271HCL Recombinant Human FDFT1 293 Cell Lysate HEK293 N/A
Human FDFT1-3282H Recombinant Human FDFT1 Protein (His269-His417), His tagged E.coli His His269-His417
Human FDFT1-4025H Recombinant Human FDFT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FDFT1-4057H Recombinant Human FDFT1 Protein, GST-tagged Wheat Germ GST
Human FDFT1-2894H Recombinant Human FDFT1 protein, His-tagged E.coli His 2-417aa
Human FDFT1-167HF Recombinant Full Length Human FDFT1 Protein In Vitro Cell Free System 417 amino acids
Human FDFT1-4774HF Recombinant Full Length Human FDFT1 Protein, GST-tagged In Vitro Cell Free System GST 417 amino acids
Human FDFT1-1048HFL Recombinant Full Length Human FDFT1 Protein, C-Flag-tagged Mammalian cells Flag
Human FDFT1-904H-B Recombinant Human FDFT1 Protein Pre-coupled Magnetic Beads HEK293
Human FDFT1-904H Recombinant Human FDFT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse FDFT1-5803M Recombinant Mouse FDFT1 Protein Mammalian Cell His
Mouse Fdft1-1830M Recombinant Mouse Fdft1 protein, His-tagged E.coli His Ile217~His416 (Accession # P53798)
Mouse FDFT1-3201M-B Recombinant Mouse FDFT1 Protein Pre-coupled Magnetic Beads HEK293
Mouse FDFT1-3201M Recombinant Mouse FDFT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Fdft1-2980M Recombinant Mouse Fdft1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat FDFT1-2308R Recombinant Rat FDFT1 Protein Mammalian Cell His
Rat Fdft1-1831R Recombinant Rat Fdft1 protein, His-tagged E.coli His Phe187~His416 (Accession # Q02769)
Rat FDFT1-1965R Recombinant Rat FDFT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FDFT1-1965R-B Recombinant Rat FDFT1 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL4907BF Recombinant Full Length Bovine Squalene Synthase(Fdft1) Protein, His-Tagged E.coli expression system His Full Length (1-417)
Homo sapiens (Human) RFL13592HF Recombinant Full Length Human Squalene Synthase(Fdft1) Protein, His-Tagged E.coli expression system His Full Length (1-417)
Mus musculus (Mouse) RFL12338MF Recombinant Full Length Mouse Squalene Synthase(Fdft1) Protein, His-Tagged E.coli expression system His Full Length (1-416)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL1110PF Recombinant Full Length Pongo Abelii Squalene Synthase(Fdft1) Protein, His-Tagged E.coli expression system His Full Length (1-417)
Rhesus Macaque FDFT1-1683R Recombinant Rhesus monkey FDFT1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque FDFT1-1505R Recombinant Rhesus Macaque FDFT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FDFT1-1505R-B Recombinant Rhesus Macaque FDFT1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish FDFT1-7996Z Recombinant Zebrafish FDFT1 Mammalian Cell His
Chicken FDFT1-3354C Recombinant Chicken FDFT1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

FDFT1 involved in several pathways and played different roles in them. We selected most pathways FDFT1 participated on our site, such as Steroid biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FDFT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Steroid biosynthesisCYP2R1;LIPA;HSD17B7;SOAT2;DHCR24;CEL.1;CELL;SQLE;SC5D
Metabolic pathwaysAK9;ATP5G3;HYKK;CDS2;TCIRG1;DCT;HMGCRA;MTR;LDHBA

FDFT1 has several biochemical functions, for example, farnesyl-diphosphate farnesyltransferase activity, oxidoreductase activity, squalene synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FDFT1 itself. We selected most functions FDFT1 had, and list some proteins which have the same functions with FDFT1. You can find most of the proteins on our site.

Function Related Protein
farnesyl-diphosphate farnesyltransferase activity
oxidoreductase activityALDH2.2;ADH1;CYP2AA7;AKR1B7;CYP2D26;VAT1;DHRS13L1;CYP2A12;F8
squalene synthase activity

FDFT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FDFT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FDFT1.

PSTPIP1; SMNDC1; C1orf168; RUVBL1; ANXA5; ITGB5; SHPRH; ARL6IP1; TMEM43; RUVBL2; 15-deoxy-delta(12,14; FN1; 1C; HDAC10

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