Recombinant Human FDFT1 Protein (His269-His417), His tagged

• Cat.No.: FDFT1-3282H
• Product Overview: Recombinant human FDFT1 (His269-His417) protein fused with His tag was expressed in E. coli.

Specification

• Description: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 17.42 kDa
• Protein Length: His269-His417
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: FDFT1 farnesyl-diphosphate farnesyltransferase 1 [ Homo sapiens (human) ]
• Official Symbol: FDFT1
• Synonyms: FDFT1; farnesyl-diphosphate farnesyltransferase 1; squalene synthase; squalene synthetase; FPP:FPP farnesyltransferase; presqualene-di-diphosphate synthase; SS; SQS; DGPT; ERG9
• Gene ID: 2222
• mRNA Refseq: NM_004462
• Protein Refseq: NP_004453
• MIM: 184420
• UniProt ID: P37268