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FES

  • Official Full Name

    feline sarcoma oncogene

  • Overview

    This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.
  • Synonyms

    FES; feline sarcoma oncogene; feline sarcoma (Snyder Theilen) viral (v fes)/Fujinami avian sarcoma (PRCII) viral (v fps) oncogene homolog; tyrosine-protein kinase Fes/Fps; c fes/fps protein; FPS; Oncogene FES; feline sarcoma virus; p93c-fes; proto-oncogen;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FES-1404H Active Recombinant Human FES, GST-tagged Sf9 Insect Cell GST Full length
Human FES-80H Active Recombinant Human FES(2-end) Protein, N-His-tagged Sf21 His 2-end
Human FES-902H Recombinant Human FES protein(Met1-Arg822), His&GST-tagged Insect Cells N-His&GST Met1-Arg822
Human FES-311H Recombinant Human Feline Sarcoma Oncogene, GST-tagged, Active Sf9 Insect Cell GST
Human FES-606HCL Recombinant Human FES cell lysate Insect Cell N/A
Human FES-3307H Recombinant Human FES protein, His-tagged E.coli His 125-390 aa
Human FES-4078H Recombinant Human FES Protein, GST-tagged Wheat Germ GST
Human FES-1322S Recombinant Human FES Protein (I448-R822), His tagged E.coli His I448-R822
Human FES-1627H Recombinant Human FES protein, His & T7-tagged E.coli His/T7 Leu509~Asn766 (Accession # P07332)
Human FES-1506HF Active Recombinant Full Length Human FES Protein, GST-tagged Insect (sf21) GST 1-413, 416-822
Human FES-1321S Recombinant Human FES Protein (I448-R822), Tag Free E.coli No tag I448-R822
Human FES-4793HF Recombinant Full Length Human FES Protein, GST-tagged In Vitro Cell Free System GST 822 amino acids
Mouse FES-5820M Recombinant Mouse FES Protein Mammalian Cell His
Mouse Fes-1628M Recombinant Mouse Fes protein, His & T7-tagged E.coli His/T7 Asp510~Arg770 (Accession # P16879)
Mouse FES-3212M-B Recombinant Mouse FES Protein Pre-coupled Magnetic Beads HEK293
Mouse FES-3212M Recombinant Mouse FES Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish FES-7883Z Recombinant Zebrafish FES Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

FES involved in several pathways and played different roles in them. We selected most pathways FES participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with FES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceEFNA1A;ANK2B;SPNA2;ARPC5;PPP3R1;KLB;TRPC5;JAK1;EPHB4A

FES has several biochemical functions, for example, ATP binding, immunoglobulin receptor binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FES itself. We selected most functions FES had, and list some proteins which have the same functions with FES. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMYO5B;SUCLG1;COASY;MCCC1;CDK18;PIP4K2B;CAMK1DB;LIG4;ATP13A1
immunoglobulin receptor bindingFES;Ighg;Ighg2b;IgG3;CLEC4D;FGR;IGKC;IGLL1;Ighg2a
microtubule bindingMID2;BCL2L11;MTAP7D3;MTAP4;CASC1;APC2;MTAP1B;RACGAP1;DCX
non-membrane spanning protein tyrosine kinase activityPTK2B;TEC;CSK;PKDCC;ITK;PTK2BB;MATK;BTK;PTK6B
phosphatidylinositol bindingMITD1;ITPR2;PLD2;HIP1R;SNX9;SNX27B;CCDC88A;HIP1;SNX8
protein bindingEXOC7;RAB1;MLKL;RAB21;FKBP4;LOXL4;CXCL14;HAND1;VDR
protein tyrosine kinase activityFGFR1B;ERBB4A;ZAP70;EGFRA;MAP2K3;MET;CLK4;Fert2;EPHB3A

FES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FES here. Most of them are supplied by our site. Hope this information will be useful for your research of FES.

EZR; TERF1; MDFI; EGFR; MET; AR; KIT; NSF

Research Area

Related articles

Zeng, XM; Mo, YM; et al. Identification and characterization of a periplasmic trilactone esterase, Cee, revealed unique features of ferric enterobactin acquisition in Campylobacter. MOLECULAR MICROBIOLOGY 87:594-608(2013).
Le, HT; Gautier, V; et al. YajL, Prokaryotic Homolog of Parkinsonism-associated Protein DJ-1, Functions as a Covalent Chaperone for Thiol Proteome. JOURNAL OF BIOLOGICAL CHEMISTRY 287:5861-5870(2012).
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