Recombinant Human FES Protein (I448-R822), His tagged

• Cat.No.: FES-1322S
• Product Overview: Recombinant Human 6His-TEV-FES(I448-R822 end) Protein was expressed in E. coli.

Specification

• Description: Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: I448-R822
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: FES feline sarcoma oncogene [ Homo sapiens (human) ]
• Official Symbol: FES
• Synonyms: FES; feline sarcoma oncogene; feline sarcoma (Snyder Theilen) viral (v fes)/Fujinami avian sarcoma (PRCII) viral (v fps) oncogene homolog; tyrosine-protein kinase Fes/Fps; c fes/fps protein; FPS; Oncogene FES; feline sarcoma virus; p93c-fes; proto-oncogene c-Fes; proto-oncogene c-Fps; Oncogene FES, feline sarcoma virus; proto-oncogene tyrosine-protein kinase Fes/Fps; feline sarcoma/Fujinami avian sarcoma oncogene homolog; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog
• Gene ID: 2242
• mRNA Refseq: NM_001143783
• Protein Refseq: NP_001137255
• MIM: 190030
• UniProt ID: P07332