FGA

  • Official Full Name

    fibrinogen alpha chain

  • Overview

    The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.
  • Synonyms

    Fibrinogen; FGA; FGA protein; FGB; FGG; Fib2; Fibrinogen A alpha polypeptide; Fibrinogen A alpha polypeptide chain; Fibrinogen alpha chain; Fibrinogen B alpha polypeptide; Fibrinogen beta chain; Fibrinogen G alpha polypeptide; Fibrinogen gamma chain; MGC104327; MGC119422; MGC119423; MGC119425; MGC120405;

  • Native Proteins
  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Cattle
  • Chicken
  • Dog
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Zebrafish
  • Bovine Plasma
  • Dog Plasma
  • E.coli
  • HEK293
  • Human plasma
  • Human Plasma
  • In Vitro Cell Free System
  • Mammalian Cell
  • Plasma
  • Protein Conjugation
  • Rabbit Plasma
  • Rat plasma
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FGA-78H Active Native Human Fibrinogen (Pg & vWF depleted) Human Plasma N/A
Human FGA-79H Active Native Human Fibrinogen Human Plasma N/A
Human FGA-80H Active Native Human Fibrinogen (plasminogen depleted) Human Plasma N/A
Human FGA-36H Recombinant Human FGA protein, His-tagged E.coli His
Human FGA-206H Recombinant Human FGA Mammalian Cell His
Human FGA-618HCL Recombinant Human FGA cell lysate N/A
Human FGA-5H Native Human Fibrinogen, FITC Labeled Human plasma N/A
Human FGA-2900H Recombinant Human FGA protein, His-tagged E.coli His
Human FGA-2429H Recombinant Human FGA Protein (Ala20-Arg218), N-His tagged E.coli N-His
Human FGA-4087H Recombinant Human FGA Protein, GST-tagged Wheat Germ GST
Human FGA-4803HF Recombinant Full Length Human FGA Protein, GST-tagged In Vitro Cell Free System GST
Human FGA-2945H Recombinant Human FGA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FGA-2945H-B Recombinant Human FGA Protein Pre-coupled Magnetic Beads HEK293
Mouse Fga-299M Active Native Mouse Fibrinogen Plasma N/A
Mouse Fga-1545M Recombinant Mouse Fga protein, His-tagged E.coli His
Mouse FGA-5830M Recombinant Mouse FGA Protein Mammalian Cell His
Mouse Fga-1546M Recombinant Mouse Fga protein, His & T7-tagged E.coli His/T7
Mouse FGA-3219M-B Recombinant Mouse FGA Protein Pre-coupled Magnetic Beads HEK293
Mouse FGA-3219M Recombinant Mouse FGA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Fga-1547R Recombinant Rat Fga protein, His-tagged E.coli His
Rat Fga-1548R Recombinant Rat Fga protein, His-tagged E.coli His
Rat Fga -67R Native Rat Fibrinogen Rat plasma N/A
Rat Fga-63R Native Rat Fibrinogen, FITC Labeled Rat plasma N/A
Rat Fga-2808R Recombinant Rat Fga Protein, His-tagged, OVA Conjugated Protein Conjugation N-His
Rabbit FGA-58R Native Rabbit Fibrinogen Rabbit Plasma N/A
Rabbit FGA-55R Native Rabbit Fibrinogen, FITC Labeled Rabbit Plasma N/A
Dog FGA-34D Native Canine Fibrinogen Dog Plasma N/A
Dog FGA-42D Native Canine Fibrinogen, FITC Labeled Dog Plasma N/A
Bovine FGA-30B Native Bovine Fibrinogen Bovine Plasma N/A
Bovine FGA-39B Native Bovin Fibrinogen, FITC Labeled Bovine Plasma N/A
Cattle FGA-1544C Recombinant Cattle FGA protein, His & T7-tagged E.coli His/T7
Zebrafish FGA-7799Z Recombinant Zebrafish FGA Mammalian Cell His
Chicken FGA-6908C Recombinant Chicken FGA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FGA Related Articles
  • FGA Related Research Area

FGA involved in several pathways and played different roles in them. We selected most pathways FGA participated on our site, such as Complement and coagulation cascades, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesFGB;F13B;VWF;C4BPA;FGA;LOC100514666;C4BPB;KLKB1;C8B
Platelet activationTBXAS1;MAPK13;AKT1;TLN1;PLA2G4A;STIM1;ITPR3;GP6;ARHGEF1

FGA has several biochemical functions, for example, contributes_to cell adhesion molecule binding, protein binding, protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by FGA itself. We selected most functions FGA had, and list some proteins which have the same functions with FGA. You can find most of the proteins on our site.

Function Related Protein
contributes_to cell adhesion molecule bindingFGA;FGB
protein bindingRAB37;ZCCHC11;SMARCC1;MAPK8IP2;TRIM67;MARCH5;LSAMP;RPRD1A;VLDLR
protein binding, bridgingSTX1A;TRIM17;PPP2R3A;CAV2;ST13;CBX5;COL1A2;PPP4R2;FSCN2
contributes_to receptor bindingFGA;FGB
structural molecule activityCLDNB;SPRR1A;TUBA1A;KRT4;SEPT5;LMNA;CLDN17;KRT71;COPG

FGA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGA here. Most of them are supplied by our site. Hope this information will be useful for your research of FGA.

FGB; FGG; APOA1; KLK6; PASK; F2; MIS12; KRT18; p29991-pro_0000037941; p29991-pro_0000037946; PRRC2A; d-mannose; crlkekhc; IGHG1; IGHA1; ALB

Nimje, SV; Panigrahi, SK; et al. Interfacial failure analysis of functionally graded adhesively bonded double supported tee joint of laminated FRP composite plates. INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES 58:70-79(2015).
Jobse, A; Pieters, M; et al. The contribution of genetic and environmental factors to changes in total and gamma ' fibrinogen over 5 years. THROMBOSIS RESEARCH 135:703-709(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is FGA protein measured in clinical practice? 04/18/2023

FGA protein levels can be measured through laboratory tests such as fibrinogen assays and coagulation profiles.

How is FGA protein testing used in the evaluation of liver function? 02/03/2023

FGA protein testing is used as part of the assessment of liver function, as the liver is responsible for the synthesis of fibrinogen.

What are the implications of low FGA protein levels? 05/04/2021

Low FGA protein levels may lead to an increased risk of bleeding and impaired clot formation.

What conditions may lead to abnormal FGA protein levels? 11/19/2020

Conditions such as liver disease, disseminated intravascular coagulation (DIC), and congenital fibrinogen deficiencies can lead to abnormal FGA protein levels.

How are abnormal FGA protein levels managed? 09/17/2018

Treatment for abnormal FGA protein levels may involve addressing the underlying condition and, in some cases, administering fibrinogen replacement therapy.

Customer Reviews (3)

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Reviews
01/29/2023

    the manufacturer understands the importance of customization and can offer tailored solutions to meet specific research needs.

    05/02/2021

      From recombinant protein production to modification or labeling services, the company is committed to assisting researchers in obtaining the FGA protein in the format and specifications required for their particular studies.

      01/15/2019

        the FGA protein's exceptional qualities, combined with the manufacturer's comprehensive technical support, make it an ideal choice for researchers seeking reliable experimental materials and reliable assistance in their scientific endeavors.

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