Recombinant Human FGA protein, His-tagged

• Cat.No.: FGA-36H
• Product Overview: Recombinant Human FGA(Asp124~Pro214) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 16.5kDa
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 90%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: FGA fibrinogen alpha chain [ Homo sapiens ]
• Official Symbol: FGA
• Synonyms: FGA; fibrinogen alpha chain; fibrinogen, A alpha polypeptide; Fib2; MGC119422; MGC119423; MGC119425
• Gene ID: 2243
• mRNA Refseq: NM_000508
• Protein Refseq: NP_000499
• UniProt ID: P02671
• Chromosome Location: 4q28
• Pathway: Amyloids, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Disease, organism-specific biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem
• Function: eukaryotic cell surface binding; protein binding; protein binding, bridging; receptor binding

Reviews

01/29/2023

the manufacturer understands the importance of customization and can offer tailored solutions to meet specific research needs.

05/02/2021

From recombinant protein production to modification or labeling services, the company is committed to assisting researchers in obtaining the FGA protein in the format and specifications required for their particular studies.

01/15/2019

the FGA protein's exceptional qualities, combined with the manufacturer's comprehensive technical support, make it an ideal choice for researchers seeking reliable experimental materials and reliable assistance in their scientific endeavors.

Q&As

How is FGA protein measured in clinical practice?

FGA protein levels can be measured through laboratory tests such as fibrinogen assays and coagulation profiles.

How is FGA protein testing used in the evaluation of liver function?

FGA protein testing is used as part of the assessment of liver function, as the liver is responsible for the synthesis of fibrinogen.

What are the implications of low FGA protein levels?

Low FGA protein levels may lead to an increased risk of bleeding and impaired clot formation.

What conditions may lead to abnormal FGA protein levels?

Conditions such as liver disease, disseminated intravascular coagulation (DIC), and congenital fibrinogen deficiencies can lead to abnormal FGA protein levels.

How are abnormal FGA protein levels managed?

Treatment for abnormal FGA protein levels may involve addressing the underlying condition and, in some cases, administering fibrinogen replacement therapy.