Recombinant Human FGA Protein, GST-tagged

• Cat.No.: FGA-4087H
• Product Overview: Human FGA full-length ORF ( AAH20764, 1 a.a. - 218 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 49.72 kDa
• AA Sequence: MFSMSIVCLVLSVVGTAWTADSGEG DFLAEGGGVRGPRVVERHQSACKDS DWPFCSGEDWNYKCPSGCRMKGLID EVNQDFTNRINKLKNSLFEYQKNNK DSHSLTTNIMEILRGDFSSANNRDN TYNRVSEDLRSRIEVLKRKVIEKVT ANNLLVARVTTEETPHLKARAIKWQ MRPEVKPIMKEHIAPREAMLNLALS EVSTLLLWGSLPCPPRLS
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FGA fibrinogen alpha chain [ Homo sapiens ]
• Official Symbol: FGA
• Synonyms: FGA; fibrinogen alpha chain; fibrinogen, A alpha polypeptide; Fib2; MGC119422; MGC119423; MGC119425
• Gene ID: 2243
• mRNA Refseq: NM_000508
• Protein Refseq: NP_000499
• MIM: 134820
• UniProt ID: P02671