| Description : |
This gene encodes a subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded protein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mice lacking the encoded protein display bleeding in the peritoneal cavity, skin and soft tissues around joints immediately after birth, and are predisposed to spontaneous fatal abdominal hemorrhage as they grow. Pregnant mice lacking the encoded protein succumb to uterine bleeding during gestation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. |
| Source : |
E. coli |
| Species : |
Mouse |
| Tag : |
His & T7 |
| Form : |
Freeze-dried powder |
| Molecular Mass : |
Predicted Molecular Mass: 29.6kDa. |
| Protein length : |
Gly34~Met255 (Accession # E9PV24) |
| Endotoxin : |
<1.0EU per 1µg (determined by the LAL method). |
| Purity : |
>95% |
| Characteristic : |
The isoelectric point is 6.3. |
| Applications : |
SDS-PAGE; WB; ELISA; IP. |
| Stability : |
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
| Storage : |
Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
| Storage buffer : |
Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl. |
| Reconstitution : |
Reconstitute in sterile PBS, pH7.2-pH7.4. |
