fhl2
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  • Official Full Name
  • four and a half LIM domains 2
  • Background
  • Proteins containing LIM domains (which are double zinc finger motifs implicated in protein binding) are important regulators of cell growth, cell differentiation, and remodeling of the cell cytoskeleton. Human Four-and-a-half LIM-only protein 2 (FHL2), al
  • Synonyms
  • FHL2; four and a half LIM domains 2; four and a half LIM domains protein 2; DRAL; SLIM3; LIM domain protein DRAL; aging-associated gene 11; skeletal muscle LIM-protein 3; four and a half LIM-domain protein 2; down-regulated in rhabdomyosarcoma LIM protein
Cat.#:FHL2-4162HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FHL2 Protein, GST-tagged
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Cat.#:FHL2-634HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human four and a half LIM domains 2, His-tagged
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Cat.#:FHL2-793HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FHL2 Protein, His-tagged
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Cat.#:FHL2-5876MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FHL2 Protein
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Cat.#:FHL2-2345RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FHL2 Protein
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Cat.#:FHL2-6223HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FHL2 293 Cell Lysate
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Cat.#:FHL2-6224HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FHL2 293 Cell Lysate
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Involved Pathway

FHL2 involved in several pathways and played different roles in them. We selected most pathways FHL2 participated on our site, such as Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FHL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Osteoclast differentiation
MAPK8; TNFRSF1A; NOX3; AKT1; NCF4; TNF; FCGR4; SIRP-BETA; PPARG; TREM2

Protein Function

FHL2 has several biochemical functions, for example, androgen receptor binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FHL2 itself. We selected most functions FHL2 had, and list some proteins which have the same functions with FHL2. You can find most of the proteins on our site.
Function
Related Protein
Function androgen receptor binding
Related Protein DDX5; FOXP1; FOXH1; PRKCBB; KAT5; CCNE1; NRIP1; CDK7; PIAS2; FHL2
Function identical protein binding
Related Protein RYR2; CBX3; CLDN14; CLDN6; ABCD1; CCDC91; CCL3; CRYBB2; MRI1; ESR1
Function protein binding
Related Protein BLOC1S2A; WAS; TFAP2B; OGT; ACMSD; RNF13; NRF1; UBE2F; ISOC2; TRIP12
Function transcription coactivator activity
Related Protein APEX1; TAF5L; PQBP1; TAF6L; ACTL6A; RARA; HIF3A; TFDP1; CTBP2; CITED1
Function transcription factor binding
Related Protein KCNA3; SUFU; PPP1R13BB; PRICKLE1; RBFOX2; NKX2-1; BCL2; MED6; THRA; MECP2
Function zinc ion binding
Related Protein CPA3; TRIM108; GATAD2A; MMP17; MEP1A; TRIM21; TRIM17; FUS; RNF125; VDRA

Interacting Protein

FHL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FHL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FHL2.
BRCA1; RFX3; GNG12; FOXO1

FHL2 Related Articles

Verset, L; Tommelein, J; et al. Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer. BRITISH JOURNAL OF CANCER 109:114-120(2013).
Huss, S; Stellmacher, C; et al. Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice. BMC GASTROENTEROLOGY 13:-(2013).