FKBP1B

Official Full Name

FK506 binding protein 1B, 12.6 kDa
Overview

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.
Synonyms

FKBP1B; FK506 binding protein 1B, 12.6 kDa; FK506 binding protein 1B (12.6 kD) , FKBP1L; peptidyl-prolyl cis-trans isomerase FKBP1B; FKBP9; FKBP12.6; OTK4; PPIase; 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; Calstabin 2; FK506 binding protein 1 like; FK506 binding protein 12.6; FK506 binding protein 1B 12.6 kDa; FK506 binding protein 1B; FK506-binding protein 1B; FKB1B_HUMAN; FKBP 12.6; FKBP 1B; FKBP 1L; FKBP 9; FKBP-12.6; FKBP-1B; FKBP1L; h FKBP 12; h-FKBP-12; Immunophilin FKBP12.6; OTK 4; Peptidyl prolyl cis trans isomerase 1B; Peptidyl prolyl cis trans isomerase; PKBP 1L; PKBP1L; PPIase 1B; PPIase FKBP1B; Rotamase 1B; Rotamase; OTTHUMP00000116040; OTTHUMP00000116041; FK506-binding protein 12.6; 12.6 kDa FK506-binding;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Cattle
Chicken
Human
Mouse
Rat
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FKBP1B-1522H	Active Recombinant Human FK506 Binding Protein 1B, 12.6 kDa, His-tagged	E.coli	His	130aa	Inquiry
Human	FKBP1B-2500H	Active Recombinant Human FK506 Binding Protein 1B, 12.6 KDa, His-tagged	E.coli	His	1-108aa	Inquiry
Human	FKBP1B-28914TH	Recombinant Human FKBP1B, His-tagged	E.coli	His	108 amino acids	Inquiry
Human	FKBP1B-5252H	Recombinant Human FKBP1B Protein	E.coli	Non	1-108	Inquiry
Human	FKBP1B-6209HCL	Recombinant Human FKBP1B 293 Cell Lysate	HEK293	Non		Inquiry
Human	FKBP1B-4187H	Recombinant Human FKBP1B Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FKBP1B-001H	Recombinant Human FKBP1B Protein	E.coli		1-108	Inquiry
Human	FKBP1B-3240H	Recombinant Human FKBP1B Protein (Gly2-Glu108), N-His tagged	E.coli	His	Gly2-Glu108	Inquiry
Human	FKBP1B-1346H	Recombinant Human FKBP1B Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	FKBP1B-4800HF	Recombinant Full Length Human FKBP1B Protein, GST-tagged	In Vitro Cell Free System	GST	80 amino acids	Inquiry
Mouse	Fkbp1b-3024M	Recombinant Mouse Fkbp1b Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Rat	FKBP1B-2354R	Recombinant Rat FKBP1B Protein	Mammalian Cell	His		Inquiry
Rat	FKBP1B-2010R	Recombinant Rat FKBP1B Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	FKBP1B-2010R-B	Recombinant Rat FKBP1B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Cattle	FKBP1B-2187C	Recombinant Cattle FKBP1B Protein, His-tagged	E.coli	His	Gly2-Glu108	Inquiry
Rhesus Macaque	FKBP1B-1719R	Recombinant Rhesus monkey FKBP1B Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	FKBP1B-1541R-B	Recombinant Rhesus Macaque FKBP1B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	FKBP1B-1541R	Recombinant Rhesus Macaque FKBP1B Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Zebrafish	FKBP1B-11068Z	Recombinant Zebrafish FKBP1B	Mammalian Cell	His		Inquiry
Chicken	FKBP1B-6136C	Recombinant Chicken FKBP1B	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

FKBP1B involved in several pathways and played different roles in them. We selected most pathways FKBP1B participated on our site, such as Integrated Pancreatic Cancer Pathway, Ion channel transport, Stimuli-sensing channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Integrated Pancreatic Cancer Pathway	CST3;BRF1;TOP1;GPRC5A;IL11;TFF1;MAPK4;LEFTY1;CASP12
Ion channel transport	BEST4;TRPC4A;ATP1A1A.4;SLC9B2;FKBP1B;BSND;CCC2;FXYD6-FXYD2;ATP2B1B
Stimuli-sensing channels	TRPM1;CLCN1A;CLCN1;ANO5B;TTYH3;SLC9B2;SLC9A10;BEST3;GSDMA2
Transmembrane transport of small molecules	SLCO2A1;SLC7A6;ABCC9;DMTN;CLCNKA;SLCO4A1;SLC22A7;FXYD3;SLC6A20

FKBP1B has several biochemical functions, for example, FK506 binding, calcium channel inhibitor activity, cyclic nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP1B itself. We selected most functions FKBP1B had, and list some proteins which have the same functions with FKBP1B. You can find most of the proteins on our site.

Function	Related Protein
FK506 binding	FKBP6;FKBP11;FKBP1A;FKBP14;FKBP5;FKBP10;TTC9B;FKBP1AB;FKBP3
calcium channel inhibitor activity	FKBP1AB;AMBP;SLC30A1;PACSIN3;TNNI3;SLC30A1B;FKBP1B;SLC30A1A;CCDC109B
cyclic nucleotide binding	FKBP1B;CNP
ion channel binding	AP2M1;PKD1;AKAP9;FYN;PIRT;RYR2;PACS1;DLG1;CALM1
peptidyl-prolyl cis-trans isomerase activity	PPIL6;PPIAA;FKBP14;PPIFA;PPP2R4;FKBP4;FKBP8;FKBP10B;FKBP1AB
protein binding	LRP1;TEX14;PRAM1;IRF8;KHDRBS1;BDKRB2;C17orf62;KLHL35;ATG14
receptor binding	TNFSF8;RASA1;AGRP;PTK6;GFRA1;RSPO3;CX3CL1;PTK2AB;ABL2
contributes_to ryanodine-sensitive calcium-release channel activity

FKBP1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP1B here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP1B.

RYR2; REL; CAMK2D; KRT31; FLJ13057; KRT40

Research Area

Phosphatases and Regulators

Gant, JC; Blalock, EM; et al. FK506-binding protein 1b/12.6: A key to aging-related hippocampal Ca2+ dysregulation?. EUROPEAN JOURNAL OF PHARMACOLOGY 739:74-82(2014).

Francia, P; Adduci, C; et al. Common genetic variants in selected Ca2+ signaling genes and the risk of appropriate ICD interventions in patients with heart failure. JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY 38:169-177(2013).