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Official Full Name FK506 binding protein 1B, 12.6 kDa
Background The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.
Synonyms FKBP1B; FK506 binding protein 1B, 12.6 kDa; FK506 binding protein 1B (12.6 kD) , FKBP1L; peptidyl-prolyl cis-trans isomerase FKBP1B; FKBP9; FKBP12.6; OTK4; PPIase; 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; Calstabin 2; FK506 binding protein 1 like; FK506 binding protein 12.6; FK506 binding protein 1B 12.6 kDa; FK506 binding protein 1B; FK506-binding protein 1B; FKB1B_HUMAN; FKBP 12.6; FKBP 1B; FKBP 1L; FKBP 9; FKBP-12.6; FKBP-1B; FKBP1L; h FKBP 12; h-FKBP-12; Immunophilin FKBP12.6; OTK 4; Peptidyl prolyl cis trans isomerase 1B; Peptidyl prolyl cis trans isomerase; PKBP 1L; PKBP1L; PPIase 1B; PPIase FKBP1B; Rotamase 1B; Rotamase; OTTHUMP00000116040; OTTHUMP00000116041; FK506-binding protein 12.6; 12.6 kDa FK506-binding
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FKBP1B-001H Recombinant Human FKBP1B Protein E.coli
    Human FKBP1B-1346H Recombinant Human FKBP1B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Fkbp1b-3024M Recombinant Mouse Fkbp1b Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human FKBP1B-1522H Recombinant Human FK506 Binding Protein 1B, 12.6 kDa, His-tagged E.coli His
    Human FKBP1B-2500H Recombinant Human FK506 Binding Protein 1B, 12.6 KDa, His-tagged E.coli His
    Human FKBP1B-28914TH Recombinant Human FKBP1B, His-tagged E.coli His
    Human FKBP1B-4187H Recombinant Human FKBP1B Protein, GST-tagged Wheat Germ GST
    Human FKBP1B-5252H Recombinant Human FKBP1B Protein E.coli N/A
    Human FKBP1B-6209HCL Recombinant Human FKBP1B 293 Cell Lysate HEK293 N/A
    Rat FKBP1B-2354R Recombinant Rat FKBP1B Protein Mammalian Cell His
    Rhesus Macaque FKBP1B-1719R Recombinant Rhesus monkey FKBP1B Protein, His-tagged Mammalian Cell His
    Chicken FKBP1B-6136C Recombinant Chicken FKBP1B Mammalian Cell His
    Zebrafish FKBP1B-11068Z Recombinant Zebrafish FKBP1B Mammalian Cell His

    fkbp1b involved in several pathways and played different roles in them. We selected most pathways fkbp1b participated on our site, such as Integrated Pancreatic Cancer Pathway, Ion channel transport, Stimuli-sensing channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with fkbp1b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Integrated Pancreatic Cancer Pathway NOXA1; CD82; TOP1; MST1; TOP2A; RAPGEF3; LEFTY1; CASP12; AGA; RB1CC1
    Ion channel transport HTR3C; ATP13A5; TRPM1; TRPC4A; ANO10A; TRPM1B; WWP1; FXYD6-FXYD2; TTYH3B; WNK1
    Stimuli-sensing channels CLIC2; ANO4; TRPC4APA; SGK2; SRI; TRPV3; SLC9B2; CLCN1A; TRPC4AP; ANO1
    Transmembrane transport of small molecules SLC7A11; SLC35A1; CLCN4-2; ABCA4A; TRPM4C; ATP1A1A.5; MRS2; NIPAL3; ADD3B; SLCO3A1

    fkbp1b has several biochemical functions, for example, FK506 binding, calcium channel inhibitor activity, cyclic nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by fkbp1b itself. We selected most functions fkbp1b had, and list some proteins which have the same functions with fkbp1b. You can find most of the proteins on our site.

    Function Related Protein
    FK506 binding FKBP10; FKBP3; FKBP7; TTC9B; FKBP9; FKBP1AA; FKBP8; FKBP2; FKBP14; FKBP6
    calcium channel inhibitor activity AMBP; PHPT1; FKBP1AB; TNNI3; FKBP1AA; PACSIN3; SLC30A1B; STX1A; CCDC109B; SLC30A1A
    cyclic nucleotide binding FKBP1B; CNP
    ion channel binding DIAP1; KCND3; HOMER1; YWHAH; FGF12; TCAP; KCNQ1; S100A10; TRAPPC2; SRI
    peptidyl-prolyl cis-trans isomerase activity PPIB; FKBP1B; TTC9B; PPIA; FKBP11; FKBP1AA; PPIF; FKBP6; FKBP10; FKBP1AB
    protein binding GNL3; DUSP12; IL36RN; PRMT8; RAET1D; RND1; CBL; DDX11; SYNM; FCHO2
    receptor binding RARA; LPL; GSTM2; P2RX7; HLA-B; CADM1; HTT; APOF; PVRL2L; CXCL12
    contributes_to ryanodine-sensitive calcium-release channel activity FKBP1B

    fkbp1b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with fkbp1b here. Most of them are supplied by our site. Hope this information will be useful for your research of fkbp1b.

    RYR2; REL; CAMK2D; KRT31; FLJ13057; KRT40

    Gant, JC; Blalock, EM; et al. FK506-binding protein 1b/12.6: A key to aging-related hippocampal Ca2+ dysregulation?. EUROPEAN JOURNAL OF PHARMACOLOGY 739:74-82(2014).
    Francia, P; Adduci, C; et al. Common genetic variants in selected Ca2+ signaling genes and the risk of appropriate ICD interventions in patients with heart failure. JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY 38:169-177(2013).

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