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FKBP1B

  • Official Full Name

    FK506 binding protein 1B, 12.6 kDa

  • Overview

    The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.
  • Synonyms

    FKBP1B; FK506 binding protein 1B, 12.6 kDa; FK506 binding protein 1B (12.6 kD) , FKBP1L; peptidyl-prolyl cis-trans isomerase FKBP1B; FKBP9; FKBP12.6; OTK4; PPIase; 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; Calstabin 2; FK506 binding protein 1 like; FK506 binding protein 12.6; FK506 binding protein 1B 12.6 kDa; FK506 binding protein 1B; FK506-binding protein 1B; FKB1B_HUMAN; FKBP 12.6; FKBP 1B; FKBP 1L; FKBP 9; FKBP-12.6; FKBP-1B; FKBP1L; h FKBP 12; h-FKBP-12; Immunophilin FKBP12.6; OTK 4; Peptidyl prolyl cis trans isomerase 1B; Peptidyl prolyl cis trans isomerase; PKBP 1L; PKBP1L; PPIase 1B; PPIase FKBP1B; Rotamase 1B; Rotamase; OTTHUMP00000116040; OTTHUMP00000116041; FK506-binding protein 12.6; 12.6 kDa FK506-binding;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FKBP1B-1522H Active Recombinant Human FK506 Binding Protein 1B, 12.6 kDa, His-tagged E.coli His 130aa
Human FKBP1B-2500H Active Recombinant Human FK506 Binding Protein 1B, 12.6 KDa, His-tagged E.coli His 1-108aa
Human FKBP1B-28914TH Recombinant Human FKBP1B, His-tagged E.coli His 108 amino acids
Human FKBP1B-5252H Recombinant Human FKBP1B Protein E.coli N/A
Human FKBP1B-6209HCL Recombinant Human FKBP1B 293 Cell Lysate HEK293 N/A
Human FKBP1B-4187H Recombinant Human FKBP1B Protein, GST-tagged Wheat Germ GST
Human FKBP1B-001H Recombinant Human FKBP1B Protein E.coli 1-108
Human FKBP1B-3240H Recombinant Human FKBP1B Protein (Gly2-Glu108), N-His tagged E.coli N-His Gly2-Glu108
Human FKBP1B-1346H Recombinant Human FKBP1B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FKBP1B-4800HF Recombinant Full Length Human FKBP1B Protein, GST-tagged In Vitro Cell Free System GST 80 amino acids
Mouse Fkbp1b-3024M Recombinant Mouse Fkbp1b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat FKBP1B-2354R Recombinant Rat FKBP1B Protein Mammalian Cell His
Rat FKBP1B-2010R Recombinant Rat FKBP1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FKBP1B-2010R-B Recombinant Rat FKBP1B Protein Pre-coupled Magnetic Beads HEK293
Cattle FKBP1B-2187C Recombinant Cattle FKBP1B Protein, His-tagged E.coli N-His Gly2-Glu108
Rhesus Macaque FKBP1B-1719R Recombinant Rhesus monkey FKBP1B Protein, His-tagged Mammalian Cell His
Rhesus Macaque FKBP1B-1541R-B Recombinant Rhesus Macaque FKBP1B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FKBP1B-1541R Recombinant Rhesus Macaque FKBP1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish FKBP1B-11068Z Recombinant Zebrafish FKBP1B Mammalian Cell His
Chicken FKBP1B-6136C Recombinant Chicken FKBP1B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FKBP1B Related Articles
  • FKBP1B Related Research Area

FKBP1B involved in several pathways and played different roles in them. We selected most pathways FKBP1B participated on our site, such as Integrated Pancreatic Cancer Pathway, Ion channel transport, Stimuli-sensing channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Integrated Pancreatic Cancer PathwayCST3;CASP12;FKBP3;LEFTY1;MST1;CD82;DAXX;JUND;FST
Ion channel transportTPCN1;CLCNK;CCC2;ANO7;CUTC;TRPM4A;TTYH1;TRPC4A;TRPM4C
Stimuli-sensing channelsTRPM4A;TRPC4AP;TTYH3B;NHEDC1;ANO10A;TRPM4C;OSTM1;ANO5;Ano3
Transmembrane transport of small moleculesADD3B;ABCA7;SLC6A6;TSC22D3;AQP11;SLC31A1;SLC16A7;SLC15A2;ABCF1

FKBP1B has several biochemical functions, for example, FK506 binding, calcium channel inhibitor activity, cyclic nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP1B itself. We selected most functions FKBP1B had, and list some proteins which have the same functions with FKBP1B. You can find most of the proteins on our site.

Function Related Protein
FK506 bindingFKBP7;FKBP1AB;FKBP10;FKBP1B;TTC9C;FKBP1AA;FKBP5;FKBP9;FKBPL
calcium channel inhibitor activitySLC30A1A;SLC30A1;PHPT1;PACSIN3;ITPR1;AMBP;FKBP1AB;FKBP1B;CCDC109B
cyclic nucleotide bindingFKBP1B;CNP
ion channel bindingKCNIP1;TRPC1;CAV3;KCNC1;PHPT1;PIRT;RANGRF;KCNE1L;GRINA
peptidyl-prolyl cis-trans isomerase activityPPIAL4C;PPIL2;FKBP14;PPIF;PPIL1;PPIFA;FKBPL;FKBP5;FKBP9
protein bindingKXD1;NGB;TBCD;NIPA2;OPA1;FBXL5;C9orf43;NOX1;AGT
receptor bindingGSTK1;CNPY4;CCL13;ADM;TNFSF18;ALCAM;F2;F2R;Artn
contributes_to ryanodine-sensitive calcium-release channel activity

FKBP1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP1B here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP1B.

RYR2; REL; CAMK2D; KRT31; FLJ13057; KRT40

Gant, JC; Blalock, EM; et al. FK506-binding protein 1b/12.6: A key to aging-related hippocampal Ca2+ dysregulation?. EUROPEAN JOURNAL OF PHARMACOLOGY 739:74-82(2014).
Francia, P; Adduci, C; et al. Common genetic variants in selected Ca2+ signaling genes and the risk of appropriate ICD interventions in patients with heart failure. JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY 38:169-177(2013).
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