FLNA
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Official Full Name
filamin A, alpha
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Overview
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
FLNA; filamin A, alpha; filamin A, alpha (actin binding protein 280) , FLN, FLN1, OPD1, OPD2; filamin-A; ABP 280; actin binding protein 280; filamin-1; alpha-filamin; non-muscle filamin; endothelial actin-binding protein; FLN; FMD; MNS; OPD; ABPX; CVD1; F;
- Recombinant Proteins
- Native Proteins
- Chicken
- Human
- Mouse
- Turkey
- Chicken Gizzard
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Turkey gizzard muscle
- Wheat Germ
- Flag
- GST
- His
- Myc
- DDK
- Myc|DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | FLNA-28906TH |
Recombinant Human FLNA, His-tagged
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E.coli | His | ||
| Human | FLNA-289H | Recombinant Human FLNA, GST-tagged | Wheat Germ | GST |
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| Human | FLNA-185H | Recombinant Human FLNA protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | FLNA-413H | Recombinant Human FLNA Protein, His-tagged | E.coli | His | Ser2~Pro274 |
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| Human | FLNA-5086H | Recombinant Human FLNA Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | FLNA-2923H | Recombinant Human FLNA protein, His&Myc-tagged | E.coli | His&Myc | 2-274aa |
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| Human | FLNA-4155HFL | Recombinant Full Length Human FLNA protein, Flag-tagged | Mamanlian cells | Flag |
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| Mouse | Flna-3038M | Recombinant Mouse Flna Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Turkey | FLNA-873T | Native Turkey FLNA Protein | Turkey gizzard muscle | N/A |
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| Chicken | FLNA-170C | Active Native chicken FLNA | Chicken Gizzard | N/A |
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| Chicken | FLNA-6143C | Recombinant Chicken FLNA | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- FLNA Related Articles
FLNA involved in several pathways and played different roles in them. We selected most pathways FLNA participated on our site, such as MAPK signaling pathway, Focal adhesion, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLNA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAPK14A;MAPK3;HSPA1B;STK4;CACNA1G;ATF4B1;MEF2CA;CDC42;FASLG |
| Focal adhesion | RAC3;ARHGAP5;VAV3;VAV2;COL1A1;COL4A1;COL6A4;PIK3CD;VASP |
| Salmonella infection | RHOGC;NOS2;WASLB;PFN2L;RAC1B;MAPK12A;NFKB1;NOS2B;WAS |
| Proteoglycans in cancer | IGF1;ERBB3;WNT16;CAMK2D;PPP1R12A;WNT1;SLC9A1;RAF1;BRAF |
FLNA has several biochemical functions, for example, Fc-gamma receptor I complex binding, Rac GTPase binding, Ral GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLNA itself. We selected most functions FLNA had, and list some proteins which have the same functions with FLNA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Fc-gamma receptor I complex binding | FLNA;FGR |
| Rac GTPase binding | CORO1C;EPS8;PKN1;ARHGEF2;SOD1;ARFIP2;PAK6;RCC2;CDKL5 |
| Ral GTPase binding | EXOC4;PIH1D2;EXOC5;USP33;LSM2;MYO1C;RALBP1;RAB34;RNF41 |
| Rho GTPase binding | IQGAP3;RHOH;ANTXR2A;DIAPH1;ARHGEF16;DAAM1;ARHGEF2;DOCK11;INF2 |
| SMAD binding | ACVR1B;TGFBRAP1;SKOR1B;FOXH1;SKILB;TGFBR2;SKIB;PURB;SKIL |
| actin filament binding | PLDN;CTNNAL1;MYO7A;LASP1;NEBL;ACTN2;LCP1;SMYHC2;ADSSL1 |
| glycoprotein binding | ERLEC1;SDC1;FYN;SERPINA1D;SERPINA1;EDEM2;ACE2;B2M;RGMA |
| mu-type opioid receptor binding | GNAO1B;WLS;GPR177;GNAS;GNAO1A;GNAO1;FLNA |
| poly(A) RNA binding | DHX35;PRPF31;DHX34;ATXN2;BICC1;UTP23;RBM26;MRPL13;FNDC3B |
| protein binding | SULT4A1;DVL3;CCK;CNEP1R1;SNX31;BIRC2;ACTN4;PRR13;GJB6 |
| protein homodimerization activity | LRRFIP1;TARS;IMPA2;BAXB;GDF6;SLC11A1;ENPP1;ALS2;PARK7 |
| protein kinase C binding | DACT3;C1QBP;SDC4;GRK5;SDPRB;UGT1A7;HDAC9;AKT1;AKT2 |
| signal transducer activity | CCR9A;GNB3;GNAL;APLNRA;PRLH2R;GNAQ;PTK2;TAS1R2.2;DRD2B |
| small GTPase binding | FGD4;RCC2;FGD1;ABCA1;TSC2;GDI2;PEX5L;FLNA;FGD3 |
| transcription factor binding | CEBPG;KCTD1;NFYC;KLF5;MED12;NBN;TRIB1;ZEB1;AHR |
FLNA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLNA here. Most of them are supplied by our site. Hope this information will be useful for your research of FLNA.
ITGB1; ITGB7; CCNB2
- Q&As
- Reviews
Q&As (6)
Ask a questionFLNA expression levels can be detected by gene sequencing, immunohistochemistry, and western blotting.
Future research on FLNA may involve more in-depth research on molecular mechanisms, new drug development, and targeted therapy strategies based on FLNA. In addition, studies may also address the function and mechanism of action of FLNA in other tissues and organs.
There are multiple interactions between FLNA and other molecules and drugs. For example, FLNA can bind to actin, affecting cell migration and morphology. In addition, some drugs can also affect FLNA expression levels or function.
It is unclear whether there is a population difference in the treatment of FLNA. However, due to factors such as individual differences and genetic polymorphisms, different populations may respond differently to treatment. Therefore, population-specific treatment strategies may need to be individually adapted and optimized.
There is currently no specific treatment for FLNA. However, drugs that target their associated signal transduction pathways or binding targets may have potential therapeutic value.
Current research on FLNA expression levels as a biomarker for disease diagnosis or prognosis is insufficient and further validation is needed.
Customer Reviews (3)
Write a reviewThe structure is stable and not prone to mutations.
Simplify complex chemical reactions and increase yields and reduce experimental time.
The combination of strong biological activity and high purity results in extremely reliable results.
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