flna
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  • Official Full Name
  • filamin A, alpha
  • Background
  • The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • FLNA; filamin A, alpha; filamin A, alpha (actin binding protein 280) , FLN, FLN1, OPD1, OPD2; filamin-A; ABP 280; actin binding protein 280; filamin-1; alpha-filamin; non-muscle filamin; endothelial actin-binding protein; FLN; FMD; MNS; OPD; ABPX; CVD1; F
Cat.#:FLNA-413HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FLNA Protein, His-tagged
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Cat.#:FLNA-185HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLNA protein, MYC/DDK-tagged
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Cat.#:FLNA-28906THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FLNA, His-tagged
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Cat.#:FLNA-289HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FLNA, GST-tagged
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Cat.#:FLNA-6143CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FLNA
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Cat.#:FLNA-170CTag:
Source (Host):Species:Chicken
Product nameNative chicken FLNA
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Cat.#:FLNA-873TTag:
Source (Host):Turkey gizzard muscleSpecies:Turkey
Product nameNative Turkey FLNA Protein
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Involved Pathway

FLNA involved in several pathways and played different roles in them. We selected most pathways FLNA participated on our site, such as MAPK signaling pathway, Focal adhesion, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLNA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PPM1BB; FLNC; CACNA1SA; PLA2G4AA; PRKACAB; SRFA; PLA2G4D; RASGRF2B; GNA12; TMEM37
Focal adhesion
PIK3R2; TNXB; HRASB; PDGFRA; CAPN2B; LAMC3; THBS4; PIK3CB; CAV2; PAK1
Salmonella infection
RAB7B; IFNGR2; IL8L2; ACTB2; PFN3; ARPC5LA; RAC1A; ROCK2; MAPK13; CXCL2
Proteoglycans in cancer
DDX5; PDPK1; NANOG; CTTN; WNT9A; ITGA5; CDC42; PTPN11; FZD10; ITGB5

Protein Function

FLNA has several biochemical functions, for example, Fc-gamma receptor I complex binding, Rac GTPase binding, Ral GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLNA itself. We selected most functions FLNA had, and list some proteins which have the same functions with FLNA. You can find most of the proteins on our site.
Function
Related Protein
Function Fc-gamma receptor I complex binding
Related Protein FGR; FLNA
Function Rac GTPase binding
Related Protein PAK3; CDKL5; PAK2; MAP3K11; OCRL; PAK4; DOCK7; PAK1; CORO1C; SRGAP1
Function Ral GTPase binding
Related Protein EXOC5; RALBP1; RAB34; FLNA; PIH1D2; EXOC4; EXOC8; MYO1C; PRKCH; RNF41
Function Rho GTPase binding
Related Protein ARHGEF16; INF2; PARD6A; LRRK2; DAPK3; FLNA; ARHGEF2; KIF3B; RHOH; ANTXR2A
Function SMAD binding
Related Protein AXIN1; TGFBRAP1; COL1A2; SKOR1B; PURA; TOB1; SKOR2; ACVR1B; TGFBR2; CTNNB1
Function actin filament binding
Related Protein ESPN; FSCN2A; CORO6; MYO1E; CTNNAL1; AIF1; CORO1B; ANTXR1; TRIOBPB; EGFR
Function glycoprotein binding
Related Protein SDC1; STX1A; EDEM2; DNAJA2; SERPINA1D; SHB; BMPR1B; VWF; CANX; PTBP3
Function mu-type opioid receptor binding
Related Protein GNAS; GNAO1A; GNAO1; GPR177; GNAO1B; FLNA; WLS
Function poly(A) RNA binding
Related Protein SART1; SUB1; DDX56; CISD2; FUBP3; MEPCE; NOC4L; P4HB; CNOT1; RPUSD3
Function protein binding
Related Protein NOSTRIN; C7orf59; TREX1; GZMM; RAB23; BMP2; DLG1; ZW10; ZFHX3; PKM2
Function protein homodimerization activity
Related Protein CHMP1A; IL6R; LRRC41; DMBX1; CHMP3; RPL7; NPPC; SLC6A4; BCL2; ATIC
Function protein kinase C binding
Related Protein PARD3; AVPR1A; DACT1; HDAC9; ADD3; GLRX3; MARCKS; AKT2; PARD6A; HSPB1
Function signal transducer activity
Related Protein CCR6A; TAS2R134; CXXC5; GRM6B; EDNRAA; O3far1; TAAR12B; RGS7; MAVS; TAAR10C
Function small GTPase binding
Related Protein FLNA; PEX5; GDI2; RNF152; TSC2; RCC2; FGD1; FGD4; FGD5; ABCA1
Function transcription factor binding
Related Protein NKX2-1; TRIM11; PIM1; GATA4; PRICKLE1; CXXC5; LCOR; KCTD1; ARHGEF2; ARRB1

Interacting Protein

FLNA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLNA here. Most of them are supplied by our site. Hope this information will be useful for your research of FLNA.
ITGB1; ITGB7; CCNB2

FLNA Related Articles

Jacquemet, G; Morgan, MR; et al. Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway. JOURNAL OF CELL SCIENCE 126:4121-4135(2013).
Noam, Y; Phan, L; et al. Distinct regional and subcellular localization of the actin-binding protein filamin a in the mature rat brain. JOURNAL OF COMPARATIVE NEUROLOGY 520:3013-3034(2012).