Recombinant Human FLNA Protein, His-tagged

• Cat.No.: FLNA-413H
• Product Overview: Recombinant Human FLNA(Ser2~Pro274) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 34.3kDa
• Protein length: Ser2~Pro274
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others

Gene Information

• Gene Name: FLNA filamin A, alpha [ Homo sapiens ]
• Official Symbol: FLNA
• Synonyms: FLNA; filamin A, alpha; filamin A, alpha (actin binding protein 280) , FLN, FLN1, OPD1, OPD2; filamin-A; ABP 280; actin binding protein 280; filamin-1; alpha-filamin; non-muscle filamin; endothelial actin-binding protein; FLN; FMD; MNS; OPD; ABPX; CVD1; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280; FLJ43642; DKFZp434P031
• Gene ID: 2316
• mRNA Refseq: NM_001110556
• Protein Refseq: NP_001104026
• MIM: 300017
• UniProt ID: P21333

Reviews

11/28/2021

The structure is stable and not prone to mutations.

10/09/2021

Simplify complex chemical reactions and increase yields and reduce experimental time.

02/23/2021

The combination of strong biological activity and high purity results in extremely reliable results.

Q&As

How can FLNA expression levels be measured?

FLNA expression levels can be detected by gene sequencing, immunohistochemistry, and western blotting.

What might be involved in future research on FLNA?

Future research on FLNA may involve more in-depth research on molecular mechanisms, new drug development, and targeted therapy strategies based on FLNA. In addition, studies may also address the function and mechanism of action of FLNA in other tissues and organs.

Does FLNA interact with other molecules or drugs?

There are multiple interactions between FLNA and other molecules and drugs. For example, FLNA can bind to actin, affecting cell migration and morphology. In addition, some drugs can also affect FLNA expression levels or function.

Are there population differences in FLNA treatment?

It is unclear whether there is a population difference in the treatment of FLNA. However, due to factors such as individual differences and genetic polymorphisms, different populations may respond differently to treatment. Therefore, population-specific treatment strategies may need to be individually adapted and optimized.

What is the treatment of FLNA?

There is currently no specific treatment for FLNA. However, drugs that target their associated signal transduction pathways or binding targets may have potential therapeutic value.

Can FLNA expression level be used as a biomarker for disease diagnosis or prognosis?

Current research on FLNA expression levels as a biomarker for disease diagnosis or prognosis is insufficient and further validation is needed.