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FLNC

Official Full Name

filamin C, gamma
Overview

This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

FLNC; filamin C, gamma; filamin C, gamma (actin binding protein 280) , FLN2; filamin-C; ABP 280; ABPL; actin binding protein 280; ABP L; Actin binding like protein; Filamin 2; Filamin C; Filamin C gamma; FLJ10186; FLN 2; FLN2; Gamma actin binding protein; Gamma filamin; Protein FLNc; FLN-C; filamin-2; ABP-280-like protein; ABP-L, gamma filamin; actin-binding-like protein; ABPA; MFM5; MPD4; ABP-280; ABP280A;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads
Native Proteins

Species

Chicken
Human
Mouse
Rat

Source

Chicken Gizzard
E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FLNC-1389H	Recombinant Human FLNC protein, His & T7-tagged	E.coli	His/T7	Glu17~Lys259 (Accession # Q14315)	Inquiry
Human	FLNC-4359H	Recombinant Human FLNC Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FLNC-301631H	Recombinant Human FLNC protein, GST-tagged	E.coli	GST	Asp2161-Leu2161-2248	Inquiry
Human	FLNC-3063H	Recombinant Human FLNC protein, His-tagged	E.coli	His	2161-2248 aa	$319 / 25ug
Human	FLNC-2725H	Recombinant Human FLNC Protein (Glu17-Lys259), N-His tagged	E.coli	N-His	Glu17-Lys259	Inquiry
Mouse	FLNC-5922M	Recombinant Mouse FLNC Protein	Mammalian Cell	His		Inquiry
Mouse	Flnc-1504M	Recombinant Mouse Flnc Protein, His-tagged	E.coli	N-His	Thr2520-Pro2726	Inquiry
Mouse	FLNC-3279M	Recombinant Mouse FLNC Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	FLNC-3279M-B	Recombinant Mouse FLNC Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	FLNC-2361R	Recombinant Rat FLNC Protein	Mammalian Cell	His		Inquiry
Rat	FLNC-2017R	Recombinant Rat FLNC Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	FLNC-2017R-B	Recombinant Rat FLNC Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	FLNC-6142C	Recombinant Chicken FLNC	Mammalian Cell	His		Inquiry
Chicken	FLNC-4360C	Native Chicken Filamin C, Gamma	Chicken Gizzard	N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein

FLNC involved in several pathways and played different roles in them. We selected most pathways FLNC participated on our site, such as MAPK signaling pathway, Focal adhesion, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLNC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	CDC25B;FGF18;RASA1;HSPA6;GNG12;TGFBR2;TAOK2;IL1A;NR4A1
Focal adhesion	ITGB8;COL1A1;FLNB;GSK3B;MYLK3;ITGA5;VAV3B;MAPK4;MYL5
Salmonella infection	KLC1B;CASP1;ROCK1;MYH10;RAB7;DYNC1LI1;IL1A;DYNC1I2A;MAPK8B
Proteoglycans in cancer	HOXD10;GAB1;PLCG1;TLR2;WNT16;ERBB4;THBS1;AKT1;KRAS

FLNC has several biochemical functions, for example, actin binding, actin filament binding, ankyrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLNC itself. We selected most functions FLNC had, and list some proteins which have the same functions with FLNC. You can find most of the proteins on our site.

Function	Related Protein
actin binding	MYH13;TPM4;WAS;ANTXR2A;PFN3;DAAM1B;MYH11A;SNTA1;CNN3
actin filament binding	DBNLA;DBNLB;MTSS1;MYH11A;ADSSL1;DBNL;MYO1D;CTNNA1;CORO1C
ankyrin binding	PLEC;RHBG;FLNC;SLC4A1;KCTD6;KCNQ2;SLC8A1;RHAG;SPTBN1
cytoskeletal protein binding	Fert2;TOR1AIP1;PACSIN3;MSNA;FARP1;PTPN4B;EPB41L3B;CAPN10;PKD2

FLNC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLNC here. Most of them are supplied by our site. Hope this information will be useful for your research of FLNC.

Pcbp2; NPHP4; Grin1; Ywhae; Grin2b; Iqcb1; Rpgrip1l; Nphp1