Recombinant Full Length Human FMO5 Protein, Flag tagged

• Cat.No.: FMO5-01HFL
• Product Overview: Recombinant protein of human flavin containing monooxygenase 5 (FMO5), transcript variant 1 with Flag tag was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293T
• Tag: Flag
• Protein Length: 1-533 aa
• Description: Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.
• Form: 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
• Molecular Mass: 60 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80 centigrade. Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Concentration: > 0.05 μg/μL as determined by microplate BCA method

Gene Information

• Gene Name: FMO5 flavin containing dimethylaniline monoxygenase 5 [ Homo sapiens (human) ]
• Official Symbol: FMO5
• Synonyms: FMO5; flavin containing dimethylaniline monoxygenase 5; hBVMO1; flavin-containing monooxygenase 5; FMO 5; NADPH oxidase; NAPDH oxidase; baeyer-Villiger monooxygenase 1; dimethylaniline monooxygenase [N-oxide-forming] 5; dimethylaniline oxidase 5; flavin containing monooxygenase 5; hepatic flavin-containing monooxygenase 5; EC 1.14.13.8; EC 1.6.3.1
• Gene ID: 2330
• mRNA Refseq: NM_001461
• Protein Refseq: NP_001452
• MIM: 603957
• UniProt ID: P49326