Recombinant Human FMO5 Protein, GST-tagged

• Cat.No.: FMO5-4394H
• Product Overview: Human FMO5 full-length ORF ( AAH35687, 1 a.a. - 285 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 56.87 kDa
• AA Sequence: MTKKRIAVIGGGVSGLSSIKCCVEE GLEPVCFERTDDIGGLWRFQENPEE GRASIYKSVIINTSKEMMCFSDYPI PDHYPNFMHNAQVLEYFRMYAKEFD LLKYIRFKTTVCSVKKQPDFATSGQ WEVVTESEGKKEMNVFDGVMVCTGH HTNAHLPLESFPGIEKFKGQYFHSR DYKNPEGFTGKRVIIIGIGNSGGDL AVEISQTAKQVFLSTRRGAWILNRV GDYGYPADVLFSSRLTHFIWKICGQ SLANKYLEKKINQRFDHEMFGLKPK HRSKDIALTE
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FMO5 flavin containing monooxygenase 5 [ Homo sapiens ]
• Official Symbol: FMO5
• Synonyms: FMO5; flavin containing monooxygenase 5; dimethylaniline monooxygenase [N-oxide-forming] 5; FMO 5; dimethylaniline oxidase 5; hepatic flavin-containing monooxygenase 5
• Gene ID: 2330
• mRNA Refseq: NM_001144829
• Protein Refseq: NP_001138301
• MIM: 603957
• UniProt ID: P49326