Recombinant Human FMO5 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: FMO5-2397H
• Product Overview: FMO5 MS Standard C13 and N15-labeled recombinant protein (NP_001452) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 60 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: FMO5 flavin containing monooxygenase 5 [ Homo sapiens (human) ]
• Official Symbol: FMO5
• Synonyms: FMO5; flavin containing monooxygenase 5; dimethylaniline monooxygenase [N-oxide-forming] 5; FMO 5; dimethylaniline oxidase 5; hepatic flavin-containing monooxygenase 5
• Gene ID: 2330
• mRNA Refseq: NM_001461
• Protein Refseq: NP_001452
• MIM: 603957
• UniProt ID: P49326