The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
Folr1 involved in several pathways and played different roles in them. We selected most pathways Folr1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Folr1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Folr1 has several biochemical functions, for example, drug binding, folic acid binding, folic acid transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Folr1 itself. We selected most functions Folr1 had, and list some proteins which have the same functions with Folr1. You can find most of the proteins on our site.
Folr1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Folr1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Folr1.
Wen, YF; Graybill, WS; et al. Immunotherapy Targeting Folate Receptor Induces Cell Death Associated with Autophagy in Ovarian Cancer. CLINICAL CANCER RESEARCH 21:448-459(2015).
Kabel, M; Madore, J; et al. Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study. BRITISH JOURNAL OF CANCER 111:2297-2307(2014).
