Folr1 Protein

Folr1

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Folr1

Official Full Name folate receptor 1 (adult)
Background The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
Synonyms FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18;
    • Species :
    • Canine
    • Chicken
    • Cynomolgus/Rhesus
    • Cynomolgus/Rhesus macaque
    • Dog
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Avi
    • His
    • C-6His-Avi
    • Fc
    • GST
    • His\Avi
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Folr1-4045M Active Recombinant Mouse Folr1, His-tagged HEK293 His Inquiry
    Human FOLR1-030H Recombinant Human FOLR1 Protein, His-tagged HEK293 His
    Human FOLR1-178H Recombinant Human FOLR1, Twin-Strep-tagged HEK293 Strep II Inquiry
    Human FOLR1-3889H Recombinant Human FOLR1, His tagged Human Cell His Inquiry
    Mouse Folr1-0630M Recombinant Mouse Folr1 protein, His-tagged, Biotinylated HEK293 His Inquiry
    Mouse Folr1-4044M Recombinant Mouse Folr1, His tagged Human Cell His Inquiry
    Mouse Folr1-7816M Recombinant Mouse Folr1 protein, Avi & His-tagged HEK293 Avi/His Inquiry
    Rat FOLR1-1146R Recombinant Rat FOLR1 Protein, Fc-tagged HEK293 Fc Inquiry
    Rat FOLR1-1147R Recombinant Rat FOLR1 Protein, His-tagged HEK293 His Inquiry
    Rhesus Macaque FOLR1-1736R Recombinant Rhesus monkey FOLR1 Protein, His-tagged Mammalian Cell His Inquiry
    Canine FOLR1-1062C Recombinant Canine FOLR1 Protein, Fc-tagged HEK293 Fc Inquiry
    Canine FOLR1-1063C Recombinant Canine FOLR1 Protein, His-tagged HEK293 His Inquiry
    Chicken FOLR1-6397C Recombinant Chicken FOLR1 Mammalian Cell His Inquiry
    Human FOLR1-2103HCL Recombinant Human FOLR1 cell lysate Human Cell N/A Inquiry
    Mouse FOLR1-2113MCL Recombinant Mouse FOLR1 cell lysate Human Cell N/A Inquiry
    Dog FOLR1-1062CAF488 Recombinant Canine FOLR1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Dog FOLR1-1062CAF555 Recombinant Canine FOLR1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Dog FOLR1-1062CAF647 Recombinant Canine FOLR1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Dog FOLR1-1062CF Recombinant Canine FOLR1 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Rat FOLR1-1146RAF488 Recombinant Rat FOLR1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Rat FOLR1-1146RAF555 Recombinant Rat FOLR1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Rat FOLR1-1146RAF647 Recombinant Rat FOLR1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Rat FOLR1-1146RF Recombinant Rat FOLR1 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Human FOLR1-203H Recombinant Human FOLR1 Protein, His\Avi-tagged Human Cell His\Avi Inquiry
    Human FOLR1-301148H Recombinant Human FOLR1 protein, GST-tagged E.coli GST Inquiry
    Human FOLR1-31H Recombinant Human FOLR1 Protein, C-6His-Avi tagged, Biotinylated Human Cell C-6His-Avi Inquiry
    Human FOLR1-5035HF Recombinant Full Length Human FOLR1 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Cynomolgus/Rhesus FOLR1-953C Recombinant Cynomolgus/Rhesus FOLR1 protein, His-tagged HEK293 His Inquiry
    Human FOLR1-031H Recombinant Human FOLR1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi Inquiry
    Human FOLR1-039HG GMP Recombinant Human FOLR1 protein, His-tagged HEK293 His Inquiry
    Human FOLR1-241H Recombinant Human FOLR1 Protein, His-tagged E.coli His Inquiry
    Human FOLR1-4419H Recombinant Human FOLR1 Protein, GST-tagged Wheat Germ GST Inquiry
    Mouse FOLR1-316M Recombinant Mouse FOLR1 protein, His-tagged HEK293 His Inquiry
    Mouse FOLR1-317M Recombinant Mouse FOLR1 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Inquiry
    Rat FOLR1-1146RA Recombinant Rat FOLR1 protein, Fc-tagged, APC labeled HEK293 Fc Inquiry
    Rat FOLR1-1146RP Recombinant Rat FOLR1 protein, Fc-tagged, R-PE labeled HEK293 Fc Inquiry
    Rat Folr1-242R Recombinant Rat Folr1 Protein, His-tagged E.coli His Inquiry
    Canine FOLR1-1062CA Recombinant Canine FOLR1 protein, Fc-tagged, APC labeled HEK293 Fc Inquiry
    Canine FOLR1-1062CP Recombinant Canine FOLR1 protein, Fc-tagged, R-PE labeled HEK293 Fc Inquiry
    Cynomolgus/Rhesus macaque FOLR1-315C Recombinant Cynomolgus/Rhesus macaque FOLR1 protein, His-tagged HEK293 His Inquiry

    Folr1 involved in several pathways and played different roles in them. We selected most pathways Folr1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Folr1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis HSPA1A; GIT2; RUFY1; TFRC; VPS4A; PRKCI; PLD2; SNX3; ARAP1; VPS24

    Folr1 has several biochemical functions, for example, drug binding, folic acid binding, folic acid transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Folr1 itself. We selected most functions Folr1 had, and list some proteins which have the same functions with Folr1. You can find most of the proteins on our site.

    Function Related Protein
    drug binding PYGL; P2RX2; SRP54; FABP1; PPARD; CHKA; Alb; SRP54A; TOP2A; FSCN1
    folic acid binding FOLR2; SLC46A1; GNMT; FTCD; TYMS; FOLR3; MTHFS; DMGDH; DHFR; DAAM2
    folic acid transporter activity FOLR1; SLC25A32; FOLR2; SLC19A1; SLC46A1; DAAM2; SLC19A2
    methotrexate binding DHFR; DAAM2; FOLR2; FOLR1
    receptor activity CD2; GFRA1B; PVRL2L; MED17; FPR1; GRIA3A; MRC1; GP6; UBXN6; GRIK5

    Folr1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Folr1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Folr1.

    ganglioside_gm1; Cdk1; Cbx1; Cep76; Cep192; Trim69; Poc1b; Dync1h1; CUL3; NCAPH2; IRAK3; cona_canen

    Wen, YF; Graybill, WS; et al. Immunotherapy Targeting Folate Receptor Induces Cell Death Associated with Autophagy in Ovarian Cancer. CLINICAL CANCER RESEARCH 21:448-459(2015).
    Kabel, M; Madore, J; et al. Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study. BRITISH JOURNAL OF CANCER 111:2297-2307(2014).

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