|Official Full Name||glycine cleavage system protein H (aminomethyl carrier)|
|Background||Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.|
|Synonyms||GCSH; glycine cleavage system protein H (aminomethyl carrier); glycine cleavage system H protein, mitochondrial; lipoic acid containing protein; mitochondrial; GCE; GCSH_HUMAN; Glycine cleavage system H protein; Glycine cleavage system H protein mitochondrial; Glycine cleavage system protein H; Mitochondrial glycine cleavage system H protein; NKH; OTTHUMP00000174971; lipoic acid-containing protein; mitochondrial glycine cleavage system H-protein|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
GCSH involved in several pathways and played different roles in them. We selected most pathways GCSH participated on our site, such as Glycine, serine and threonine metabolism, Glyoxylate and dicarboxylate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCSH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Glycine, serine and threonine metabolism||ALDH7A1; PSPH; AGXTA; GAMT; SARDH; PGAM1; CBSA; DMGDH; MAOA; PIPOX|
|Glyoxylate and dicarboxylate metabolism||MCEE; HOGA1; PCCB; MUT; GLULB; MDH1AA; MDH2; GLUL; SHMT1; GCSHA|
|Metabolic pathways||GAL3ST1; PTGES; NADK; NFS1; GCSHB; INPP4AB; CYP26B1; NT5C; TBXAS1; CS|
GCSH has several biochemical functions, for example, aminomethyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GCSH itself. We selected most functions GCSH had, and list some proteins which have the same functions with GCSH. You can find most of the proteins on our site.
|aminomethyltransferase activity||AMT; GCSH|
GCSH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCSH here. Most of them are supplied by our site. Hope this information will be useful for your research of GCSH.
ZBTB16; NMI; ING5