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GFRA2

  • Official Full Name

    GDNF family receptor alpha 2

  • Overview

    Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    GFRA2; GDNF family receptor alpha 2; GDNF family receptor alpha-2; GDNFRB; NTNRA; RETL2; TRNR2; GDNFR-beta; NTNR-alpha; GFR-alpha 2; RET ligand 2; GDNFR-alpha-2; GDNF receptor beta; neurturin receptor alpha; TRN receptor, GPI-anchored; PI-linked cell-surf;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus
  • Human
  • Mouse
  • Rat
  • Rhesus macaque
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • His Fc
  • Fc
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GFRA2-893H Active Recombinant Human GFRA2 Protein, Fc Chimera Mammalian cells Fc
Human GFRA2-3162H Recombinant Human GFRA2 protein, His-tagged HEK293 His Ser22-Ser441
Human GFRA2-1619H Recombinant Human GDNF Family Receptor Alpha 2 Mammalian cells N/A
Human GFRA2-713H Recombinant Human GFRA2 Protein, His-tagged CHO His
Human GFRA2-2425HCL Recombinant Human GFRA2 cell lysate Human Cell N/A
Human GFRA2-81H-B Recombinant Human GFRA2 Protein Pre-coupled Magnetic Beads HEK293
Human GFRA2-359H Recombinant Human GFRA2 Protein, His-tagged E.coli His Thr117~Pro314
Human GFRA2-81H Recombinant Human GFRA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GFRA2-2815H Recombinant Human GFRA2 Protein (Ser22-Ser441), C-His Fc tagged Mammalian cells C-His Fc Ser22-Ser441
Human GFRA2-1525H Active Recombinant Human GFRA2 protein, Fc-tagged HEK293 Fc Ser19-Glu351
Human GFRA2-266H Recombinant Human GFRA2 Protein, His-tagged HEK293 His 464
Human GFRA2-2814H Recombinant Human GFRA2 Protein (Ser22-Ser441), C-His tagged Mammalian cells C-His Ser22-Ser441
Human GFRA2-2702H Active Recombinant Human GFRA2 protein, His-tagged HEK293 His Ser22-Ser441
Human GFRA2-2169H Recombinant Human GFRA2 protein, His-tagged HEK293 His Met1-Ser441
Human GFRA2-1529H Active Recombinant Human GFRA2 protein, His-tagged HEK293 His Ser19-Glu351
Mouse Gfra2-1742M Recombinant Mouse Gfra2 Mammalian cells N/A
Mouse Gfra2-3278M Recombinant Mouse Gfra2 protein, His-tagged HEK293 His Met1-Ser441
Mouse GFRA2-2408MCL Recombinant Mouse GFRA2 cell lysate Human Cell N/A
Mouse Gfra2-360M Recombinant Mouse Gfra2 Protein, His-tagged E.coli His Thr117~Pro314
Mouse Gfra2-947M Recombinant Mouse Gfra2 Protein, His-tagged HEK293F N-His Ser22-Ser443
Mouse Gfra2-10560M Recombinant Mouse Gfra2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GFRA2-1527M Active Recombinant Mouse GFRA2 protein, His-tagged HEK293 His Gln20-Gly349
Mouse Gfra2-10560M-B Recombinant Mouse Gfra2 Protein Pre-coupled Magnetic Beads HEK293
Rat GFRA2-1526R Active Recombinant Rat GFRA2 protein, His-tagged HEK293 His Gln20-Gly350
Cynomolgus GFRA2-1528C Active Recombinant Cynomolgus GFRA2 protein, His-tagged HEK293 His Thr21-Glu351
Rhesus macaque GFRA2-1524R Active Recombinant Rhesus macaque GFRA2 protein, His-tagged HEK293 His Thr21-Glu351
Chicken GFRA2-6658C Recombinant Chicken GFRA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GFRA2 Related Gene Family
  • GFRA2 Related Research Area
  • GFRA2 Related Signal Pathway

GFRA2 involved in several pathways and played different roles in them. We selected most pathways GFRA2 participated on our site, such as Axon guidance, Developmental Biology, NCAM signaling for neurite out-growth, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFRA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceSHB;GFRA1;LRRC4;DUSP5;EZRA;FRS2A;EPHB4B;NRG3;LIMK2
Developmental BiologyEFNA2;DUSP5;EFNA1A;SCN9A;RHOGA;ITGB3A;PCSK6;NR6A1;TCF3B
NCAM signaling for neurite out-growthCOL9A1B;GFRA4;GDNF;PSPN;GFRA1;ST8SIA2;NRTN;GFRA2;COL9A1A
NCAM1 interactionsCOL9A1A;COL9A1B;GFRA1;NRTN;PSPN;GFRA2;GFRA4;GDNF

GFRA2 has several biochemical functions, for example, glial cell-derived neurotrophic factor receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GFRA2 itself. We selected most functions GFRA2 had, and list some proteins which have the same functions with GFRA2. You can find most of the proteins on our site.

Function Related Protein
glial cell-derived neurotrophic factor receptor activityGFRA1;GFRA2;GFRA4

GFRA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFRA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GFRA2.

TGF
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