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GJA5

  • Official Full Name

    gap junction protein, alpha 5, 40kDa

  • Overview

    This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are;composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials;from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript;variants encoding the same isoform have been described.
  • Synonyms

    GJA5; gap junction protein, alpha 5, 40kDa; gap junction protein, alpha 5, 40kD (connexin 40) , gap junction protein, alpha 5, 40kDa (connexin 40); gap junction alpha-5 protein; connexin 40; CX40; connexin-40; ATFB11; MGC11185;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • Fc
  • Avi
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GJA5-13275H Recombinant Human GJA5, GST-tagged E.coli GST 1-358a.a.
Human GJA5-5921HCL Recombinant Human GJA5 293 Cell Lysate HEK293 Non
Human GJA5-5920HCL Recombinant Human GJA5 293 Cell Lysate HEK293 Non
Human GJA5-3343H Recombinant Human GJA5 Protein (Tyr227-Val358), N-His tagged E.coli His Tyr227-Val358
Human GJA5-3787H Recombinant Human GJA5 protein, His-tagged E.coli His 233-341 aa
Human GJA5-3422H Recombinant Human GJA5 protein, His-tagged E.coli His 227-358aa
Human GJA5-375H Recombinant Human GJA5 protein, GST-tagged E.coli GST 233-341 aa
Rat GJA5-2548R Recombinant Rat GJA5 Protein Mammalian Cell His
Rat Gja5-6995R Recombinant Rat Gja5 protein, His-tagged E.coli His Ala50~Glu303
Rat GJA5-2204R-B Recombinant Rat GJA5 Protein Pre-coupled Magnetic Beads HEK293
Rat GJA5-2204R Recombinant Rat GJA5 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Bos taurus (Bovine) RFL15691BF Recombinant Full Length Bovine Gap Junction Alpha-5 Protein(Gja5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-359)
Canis lupus familiaris (Dog) (Canis familiaris) RFL33773CF Recombinant Full Length Dog Gap Junction Alpha-5 Protein(Gja5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-358)
Gallus gallus (Chicken) RFL10783GF Recombinant Full Length Chicken Gap Junction Alpha-5 Protein(Gja5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-369)
Homo sapiens (Human) RFL24485HF Recombinant Full Length Human Gap Junction Alpha-5 Protein(Gja5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-358)
Rattus norvegicus (Rat) RFL23361RF Recombinant Full Length Rat Gap Junction Alpha-5 Protein(Gja5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-356)
Chicken GJA5-7053C Recombinant Chicken GJA5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

GJA5 involved in several pathways and played different roles in them. We selected most pathways GJA5 participated on our site, such as Calcium Regulation in the Cardiac Cell, Gap junction assembly, Gap junction trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with GJA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium Regulation in the Cardiac CellRGS14;RGS5;CHRM1;GJB3;CASQ1B;CASQ2;RGS6;RGS16;ANXA6
Gap junction assemblyGJA4;GJA5;GJB4;GJB3;GJB7;CX27.5;GJC1;GJB5;CX30.3
Gap junction traffickingGJC1;MYO6;GJB5;CX27.5;GJB3;GJB4;GJA4;GJB2;GJA8
Gap junction trafficking and regulationGJA4;MYO6A;CX30.3;GJD3;GJB5;DAB2;GJC1;GJB7;GJB2
Membrane TraffickingSCFD1;TGOLN2;EXOC8;ARCN1B;GJB5;NECAP1;CX27.5;GAK;TRAPPC2L
Vesicle-mediated transportTPD52L1;SEC22C;CNO;TRAPPC3;PICALMA;STXBP3;TRAPPC6BL;STAB2;SH3D19

GJA5 has several biochemical functions, for example, connexin binding, gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling, gap junction channel activity involved in cardiac conduction electrical coupling. Some of the functions are cooperated with other proteins, some of the functions could acted by GJA5 itself. We selected most functions GJA5 had, and list some proteins which have the same functions with GJA5. You can find most of the proteins on our site.

Function Related Protein
connexin bindingGJA1;CNST;CAV3;CNSTB;GJA5;CXADR
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
gap junction channel activity involved in cardiac conduction electrical couplingGJA5;GJA1
gap junction hemi-channel activityCX43;CX55.5;PANX1;CX36.7;PANX1A;CX35B;CX44.1;GJA5;CX41.8

GJA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GJA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GJA5.

MARK1; RIMS3; AAR2

Research Area

Related articles

Lu, ZQ; Sinha, A; et al. Proteomic Analysis of Human Fetal Atria and Ventricle. JOURNAL OF PROTEOME RESEARCH 13:5869-5878(2014).
Luo, XJ; Huang, L; et al. Systematic Prioritization and Integrative Analysis of Copy Number Variations in Schizophrenia Reveal Key Schizophrenia Susceptibility Genes. SCHIZOPHRENIA BULLETIN 40:1285-1299(2014).
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