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GLI2

Official Full Name

GLI family zinc finger 2
Overview

This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
Synonyms

GLI2; GLI family zinc finger 2; HPE9; THP1; THP2; zinc finger protein GLI2; oncogene GLI2; tax helper protein 1; tax helper protein 2; GLI-Kruppel family member GLI2; tax-responsive element-2 holding protein; glioma-associated oncogene family zinc finger 2; tax-responsive element-25-bp sequence binding protein;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Yeast

Tag

GST
His
His (Fc)
Avi
His|SUMO
SUMO

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GLI2-133H	Recombinant Human GLI2 protein, His/sumo-tagged	E.coli	His/SUMO		Inquiry
Human	GLI2-526H	Recombinant Human GLI2 protein, His-tagged	E.coli	His		Inquiry
Human	GLI2-2965H	Recombinant Human GLI2 protein, His-SUMO-tagged	E.coli	His-SUMO	412-641aa	Inquiry
Human	GLI2-5018H	Recombinant Human GLI2 protein, His-tagged	HEK293	His	412-641aa	Inquiry
Human	GLI2-2038H	Recombinant Human GLI2 Protein (412-641 aa), His-tagged	Yeast	His	412-641 aa	Inquiry
Human	GLI2-301505H	Recombinant Human GLI2 protein, GST-tagged	E.coli	GST	Asn601-Glu795	Inquiry
Human	GLI2-3852H	Recombinant Human GLI2 protein, His-tagged	E.coli	His	601-795 aa	$319 / 25ug
Mouse	GLI2-6402M	Recombinant Mouse GLI2 Protein	Mammalian Cell	His		Inquiry
Mouse	GLI2-3595M	Recombinant Mouse GLI2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	GLI2-3595M-B	Recombinant Mouse GLI2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	GLI2-4674C	Recombinant Chicken GLI2	Mammalian Cell	His		Inquiry
Chicken	GLI2-4673C	Recombinant Chicken GLI2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

GLI2 involved in several pathways and played different roles in them. We selected most pathways GLI2 participated on our site, such as Hedgehog signaling pathway, Hippo signaling pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Hedgehog signaling pathway	PTCH2;GAS1B;IHHA;WNT4;WNT6;CSNK1G2A;SKI;SUFU;GLI2B
Hippo signaling pathway	PPP2CA;BMP8A;FZD9;SMAD4;AXIN2;LLGL1;MOBKL1A;CTNNA2;WNT16
Pathways in cancer	CXCR4;FADD;CTNNA3;RALBP1;IGF1;WNT16;WNT10B;BCL2;RARA
Basal cell carcinoma	WNT1;HHIP;GLI2;DVL2;APC;FZD2;FZD1;FZD10;AXIN1

GLI2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLI2 itself. We selected most functions GLI2 had, and list some proteins which have the same functions with GLI2. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA binding	NRF1;MYB;ZNF713;NR2C1;MYBL1;ZNF486;NKX2-5;FOS;FOSL2
chromatin binding	SOX9A;WACA;PBRM1;SSRP1A;LEF1;HESX1;PPARG;TSHZ3;PRKAA2
protein binding	ASNS;DAXX;MYO5B;TAF6L;ETV1;LRCH1;CHMP6;C16orf79;LAT
sequence-specific DNA binding	FOXN3;ALX3;BPTF;FOXO1;VDRA;LBX1B;FOXQ1;USF2;SALL2
transcription factor activity, sequence-specific DNA binding	NR2F6;POU5F2;DMRT2B;FOXA1;IRF2;RORC;RREB1;PBX4;EGR1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	FOXJ2;POU1F1;CTCFL;HIF1A;ZNF750;RELA;FOXI1;ZIC3;NFYC
zinc ion binding	PRICKLE1A;HNF4A;MICALL2A;TRIM35-23;RXRBA;ADAM10;SUV39H1A;MMP2;MMP12

GLI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLI2.

BTRC; SMAD3; SMAD2; YWHAZ; SMAD4

Research Area

Glioma Biomarkers

Neural Stem Cell Transcription Factors

Breast Cancer Stem Cell Markers

Leukemia Cancer Stem Cell Markers

Cancer Stem Cell Transcription Factors

Paulo, SS; Fernandes-Rosa, FL; et al. Sonic Hedgehog mutations are not a common cause of congenital hypopituitarism in the absence of complex midline cerebral defects. CLINICAL ENDOCRINOLOGY 82:562-569(2015).

Memmi, EM; Sanarico, AG; et al. p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3499-3504(2015).