GLI2

  • Official Full Name

    GLI family zinc finger 2

  • Overview

    This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
  • Synonyms

    GLI2; GLI family zinc finger 2; HPE9; THP1; THP2; zinc finger protein GLI2; oncogene GLI2; tax helper protein 1; tax helper protein 2; GLI-Kruppel family member GLI2; tax-responsive element-2 holding protein; glioma-associated oncogene family zinc finger 2; tax-responsive element-25-bp sequence binding protein;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GLI2-133H Recombinant Human GLI2 protein, His/sumo-tagged E.coli His/SUMO
Human GLI2-526H Recombinant Human GLI2 protein, His-tagged E.coli His
Human GLI2-2965H Recombinant Human GLI2 protein, His-SUMO-tagged E.coli His-SUMO
Human GLI2-5018H Recombinant Human GLI2 protein, His-tagged HEK293 His
Human GLI2-2038H Recombinant Human GLI2 Protein (412-641 aa), His-tagged Yeast His
Human GLI2-301505H Recombinant Human GLI2 protein, GST-tagged E.coli GST
Human GLI2-3852H Recombinant Human GLI2 protein, His-tagged E.coli His
Mouse GLI2-6402M Recombinant Mouse GLI2 Protein Mammalian Cell His
Mouse GLI2-3595M Recombinant Mouse GLI2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GLI2-3595M-B Recombinant Mouse GLI2 Protein Pre-coupled Magnetic Beads HEK293
Chicken GLI2-4674C Recombinant Chicken GLI2 Mammalian Cell His
Chicken GLI2-4673C Recombinant Chicken GLI2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GLI2 Related Articles
  • GLI2 Related Research Area

GLI2 involved in several pathways and played different roles in them. We selected most pathways GLI2 participated on our site, such as Hedgehog signaling pathway, Hippo signaling pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hedgehog signaling pathwayIHHB;CSNK1G3;Shh;LRP2A;BMP4;SHHB;WNT11R;CSNK1G2B;SKIA
Hippo signaling pathwayWNT10B;LLGL2;WNT8A;SCRIB;WNT7B;WNT3A;YWHAE;AXIN2;FBXW11
Pathways in cancerLPAR2;LAMA1;RBX1;WNT9A;FGF12;PLEKHG5;FGF20;AXIN1;FGF13
Basal cell carcinomaFZD6;TRP53;TCF7L2;WNT1;DVL2;WNT16;LEF1;WNT5A;Shh

GLI2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLI2 itself. We selected most functions GLI2 had, and list some proteins which have the same functions with GLI2. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingNKX2-5;STAT3;POU4F2;IRF4;NEUROG3;FOXJ2;TCF3A;SMAD3;PRDM1
chromatin bindingNR5A5;ARID3A;PHF8;RBPJ;POLR3D;RNF168;MTA1;PHC1;BAHCC1
protein bindingPGF;MYH11;STUB1;PKHD1L1;MEPE;HIPK1;ZFP36;SNF8;PRMT5
sequence-specific DNA bindingZBTB4;DRGX;ZSCAN12;HIVEP3;HOXA13B;HOXB1B;HOXC3A;GLI2;LHX9
transcription factor activity, sequence-specific DNA bindingFOXG1D;BATF;INSM1A;ZXDC;TBX2A;FOXB1B;ZNF217;UBN2;ZNF480
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingSRF;SOX12;ESR1;AKNA;FOSB;PLSCR1;MAFB;HOXA7;ONECUTL
zinc ion bindingCRYZL1;CA6;TRAF3;NR4A2;DPP3;P2RX1;ADAM33;MLL5;LIN28A

GLI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLI2.

BTRC; SMAD3; SMAD2; YWHAZ; SMAD4

Paulo, SS; Fernandes-Rosa, FL; et al. Sonic Hedgehog mutations are not a common cause of congenital hypopituitarism in the absence of complex midline cerebral defects. CLINICAL ENDOCRINOLOGY 82:562-569(2015).
Memmi, EM; Sanarico, AG; et al. p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3499-3504(2015).
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