GLI2
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Official Full Name
GLI family zinc finger 2 -
Overview
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008] -
Synonyms
GLI2;GLI family zinc finger 2;HPE9;THP1;THP2;zinc finger protein GLI2;oncogene GLI2;tax helper protein 1;tax helper protein 2;GLI-Kruppel family member GLI2;tax-responsive element-2 holding protein;glioma-associated oncogene family zinc finger 2;tax-responsive element-25-bp sequence binding protein
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Yeast
- HEK293
- His
- SUMO
- GST
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GLI2-3852H | Recombinant Human GLI2 protein, His-tagged | E.coli | Human | His | 601-795 aa | |
| GLI2-133H | Recombinant Human GLI2 protein, His/sumo-tagged | E.coli | Human | His&SUMO |
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| GLI2-4673C | Recombinant Chicken GLI2 | Mammalian Cells | Chicken | His |
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| GLI2-4674C | Recombinant Chicken GLI2 | Mammalian Cells | Chicken | His |
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| GLI2-526H | Recombinant Human GLI2 protein, His-tagged | E.coli | Human | His |
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| GLI2-6402M | Recombinant Mouse GLI2 Protein | Mammalian Cells | Mouse | His |
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| GLI2-2038H | Recombinant Human GLI2 Protein (412-641 aa), His-tagged | Yeast | Human | His | 412-641 aa |
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| GLI2-2965H | Recombinant Human GLI2 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 412-641aa |
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| GLI2-301505H | Recombinant Human GLI2 protein, GST-tagged | E.coli | Human | GST | Asn601-Glu795 |
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| GLI2-3595M | Recombinant Mouse GLI2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| GLI2-3595M-B | Recombinant Mouse GLI2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GLI2-5018H | Recombinant Human GLI2 protein, His-tagged | HEK293 | Human | His | 412-641aa |
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Involved Pathway
GLI2 involved in several pathways and played different roles in them. We selected most pathways GLI2 participated on our site, such as Hedgehog signaling pathway,Hippo signaling pathway,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | FZD2,JUB,GSK3B,SOX2,CRB2,YWHAH,SAV1,PPP1CA,LLGL2,BTRC |
| Pathways in cancer | BCL2,FZD2,FGF18,PLCB2,CCDC6,CXCR4,BIRC8,PLCB4,MET,FGFR3 |
| Hedgehog signaling pathway | CSNK1DB,GLI3,WNT7AA,PRKACAB,GAS1B,WNT2BB,PRKACG,SKI,PRKACAA,GLI1 |
| Basal cell carcinoma | WNT7A,APC,TP53,FZD9,FZD10,WNT1,FZD6,WNT11,FZD8,AXIN2 |
Protein Function
GLI2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLI2 itself. We selected most functions GLI2 had, and list some proteins which have the same functions with GLI2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | OTX1A,PGBD1,HOXA6,GATA1,ENG2A,NKX3,POU2F1,FOXA,ZNF232,ARGFX |
| chromatin binding | SMARCA2,PHF21A,SSBP1,NFIA,POLA1,HINFP,NFATC3,NFATC2,GM606,MCM5 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | CARF,HOXC11,HNRNPK,ZGPAT,PDX1,SMAD6,MITFA,ASCL1,IFI203,GMEB1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | SOX9,POU4F1,FOXC2,SMAD4,SREBF1,MZF1,SRF,MYBL1,MYB,STK16 |
| zinc ion binding | ING2,TRIM105,NR4A2B,RARAA,ZDHHC15A,RAD18,NR5A1,PIAS3,RFPL3,RNF138 |
| protein binding | VPS35,FAM19A1,WDR4,GNG5,CD160,RARS,TRIP4,ZNF398,CITED1,CRYAB |
| transcription factor activity, sequence-specific DNA binding | ZSCAN16,TFDP1,ZIC3,CREMB,ZNF287,RFX5,TSC22D2,FOXO6,ELK1,FOSL1 |
Interacting Protein
GLI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLI2.
BTRC;SMAD3;SMAD2;YWHAZ;SMAD4
Resources
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References
- Paulo, SS; Fernandes-Rosa, FL; et al. Sonic Hedgehog mutations are not a common cause of congenital hypopituitarism in the absence of complex midline cerebral defects. CLINICAL ENDOCRINOLOGY 82:562-569(2015).
- Memmi, EM; Sanarico, AG; et al. p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3499-3504(2015).
