GNB4

  • Official Full Name

    guanine nucleotide binding protein (G protein), beta polypeptide 4

  • Overview

    Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.

  • Synonyms

    GNB4;guanine nucleotide binding protein (G protein), beta polypeptide 4;guanine nucleotide-binding protein subunit beta-4;G protein beta 4 subunit;GNB 4;Guanine nucleotide binding protein (G protein) beta polypeptide 4;Guanine nucleotide binding protein beta 4 subunit;Guanine nucleotide binding protein beta polypeptide 4;Guanine nucleotide binding protein beta subunit 4;Guanine nucleotide binding protein subunit beta 4;Transducin beta chain 4;G protein beta-4 subunit

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • GST
  • T7
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
GNB4-13357H Recombinant Human GNB4, GST-tagged E.coli Human GST 1-340a.a.
GNB4-1537H Recombinant Human GNB4, T7-tagged E.coli Human T7
GNB4-1899R Recombinant Rhesus monkey GNB4 Protein, His-tagged Mammalian Cells Rhesus macaque His
GNB4-2603R Recombinant Rat GNB4 Protein Mammalian Cells Rat His
GNB4-7030M Recombinant Mouse GNB4 Protein Mammalian Cells Mouse His
GNB4-5860HCL Recombinant Human GNB4 293 Cell Lysate HEK293 Human Non
GNB4-1719R Recombinant Rhesus Macaque GNB4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
GNB4-1719R-B Recombinant Rhesus Macaque GNB4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
GNB4-2258R Recombinant Rat GNB4 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
GNB4-2258R-B Recombinant Rat GNB4 Protein Pre-coupled Magnetic Beads HEK293 Rat
GNB4-3768M Recombinant Mouse GNB4 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
GNB4-3768M-B Recombinant Mouse GNB4 Protein Pre-coupled Magnetic Beads HEK293 Mouse
GNB4-5057H Recombinant Human GNB4 Protein, GST-tagged Wheat Germ Human GST
GNB4-5371HF Recombinant Full Length Human GNB4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 340 amino acids

    Involved Pathway

    GNB4 involved in several pathways and played different roles in them. We selected most pathways GNB4 participated on our site, such as Ras signaling pathway,Chemokine signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Circadian entrainment GNG5,PRKG1,GNAI3,ITPR1,CACNA1G,RYR1,PER3,GNG7,PRKG2,PLCB4
    Ras signaling pathway SHOC2,RAP1B,GRB2,RASGRF2,LOC608458,PLCG2,SHC3,FGF13,GNG12,MAPK10
    Pathways in cancer ARAF,AKT1,FZD8,GNB3,TPM3,ITGA2B,BIRC7,WNT2B,BCL2,HHIP
    GABAergic synapse GLS2,GPHN,PRKACG,GNG7,GNG12,GABRG1,GLS,GNG5,GNG4,GNG10
    Dopaminergic synapse GNG7,CALM4,CREB3L2,GRIA2,GNAO1,PRKACA,GNAI3,CAMK2B,DRD4,PRKCA
    Retrograde endocannabinoid signaling PRKCB,GABRA1,GNAI1,GABRA4,PLCB1,PRKACA,GNB1,GABRB2,GRIA3,MAPK3
    Cholinergic synapse ITPR1,CREB3L4,KCNJ6,GNG3,CREB3L3,PIK3R5,KCNJ4,PLCB1,GNA11,CHRNA3
    Serotonergic synapse GNGT1,GNB3,HTR7,MAOA,GNAI2,HTR1A,PRKCB,CYP2C50,GNAO1,PLCB3
    Glutamatergic synapse TRPC1,GRIN3A,GNG12,PLA2G4C,SHANK2,GRIK4,GRIA4,PPP3R2,GLS,PLD2

    Protein Function

    GNB4 has several biochemical functions, for example, protein complex binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB4 itself. We selected most functions GNB4 had, and list some proteins which have the same functions with GNB4. You can find most of the proteins on our site.

    Function Related Protein
    signal transducer activity VMN1R48,PLCZ1,OLFR24,O3far1,FAM126A,APLNRB,S100A9,OLFR998,GPR52,VMN1R40
    protein complex binding RAD18,NR0B2,TMED10,ITPR1,HTR2A,VPS28,CD2AP,KRT8,TUBB,RAN

    Interacting Protein

    GNB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB4.

    Cdk1;Trim69;Haus4;Haus1;q96be0_human;PFDN5;Mau2;q9hav2_human;FKBPL;NUDC;RIPK3;ESR1;NS;ERBB2;MTNR1A;MTNR1B;CDK18;Myh10

    Resources

    References

    • Liu, L; Zhang, RX; et al. Intermediate Charcot-Marie-Tooth disease. NEUROSCIENCE BULLETIN 30:999-1009(2014).
    • Baets, J; De Jonghe, P; et al. Recent advances in Charcot-Marie-Tooth disease. CURRENT OPINION IN NEUROLOGY 27:532-540(2014).

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