GRK5 involved in several pathways and played different roles in them. We selected most pathways GRK5 participated on our site, such as Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Chemokine signaling pathway |
CCL3L1; RAP1B; WAS; GNB3; Adcy4; PIK3CB; CCL1; RLN1; CCL3L3; NRAS |
| Endocytosis |
ARPC5LA; ARPC4L; SH3GLB2B; CHMP6; DNM1B; STAM2; WIPF1; SNX5; RAB10; EGFRA |
GRK5 has several biochemical functions, for example, ATP binding, G-protein coupled receptor kinase activity, beta-adrenergic receptor kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRK5 itself. We selected most functions GRK5 had, and list some proteins which have the same functions with GRK5. You can find most of the proteins on our site.
| Function |
Related Protein |
| ATP binding |
ABCA13; CSNK1G3; FER; SRMS; DDX55; MAP4K4; YTHDC2; TARS; ACTA1B; ABCB3L1 |
| G-protein coupled receptor kinase activity |
GRK1A; GRK7; GRK6; GRK5; GRK1; RLN1; GRK7A; GRK7B; GRK1B; ADRBK2 |
| beta-adrenergic receptor kinase activity |
GRK6; GRK5; ADRBK2; ADRBK1 |
| phospholipid binding |
OTC; NOXO1; PLEKHA3; APOE; GOT2; PTAFR; NBEAA; NBEAL2; LC3; OSBPL1A |
| protein binding |
MAPT; UCHL1; HBP1; USP5; IFIT3; APOBEC3H; MMS22L; TLE2; PARK7; SLC25A5 |
| protein kinase C binding |
DACT2; HDAC7; DSP; SDPRB; HDAC9; ADAM9; FLNA; PICK1; GNB2L1; UGT1A7 |
| protein serine/threonine kinase activity |
TAOK2; TAF1L; TBK1; KALRN; GRK1B; GSK3B; PLK2; STRC; BMPR1BB; HIPK2 |
GRK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRK5.
Htr4; ARRB1
Mann, A; Illing, S; et al. Different mechanisms of homologous and heterologous mu-opioid receptor phosphorylation. BRITISH JOURNAL OF PHARMACOLOGY 172:311-316(2015).
Doll, C; Poll, F; et al. Deciphering mu-opioid receptor phosphorylation and dephosphorylation in HEK293 cells. BRITISH JOURNAL OF PHARMACOLOGY 167:1259-1270(2012).
