GRK5 Protein


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Official Full Name G protein-coupled receptor kinase 5
Background This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).
Synonyms GRK5; G protein-coupled receptor kinase 5; GPRK5; FP2025; g protein-coupled receptor kinase GRK5; FLJ39780;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)-Avi
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRK5-1410H Active Recombinant Human GRK5 (Active), GST-tagged Sf9 Insect Cell GST Inquiry
    Human GRK5-13541H Recombinant Human GRK5, His-tagged E.coli His Inquiry
    Human GRK5-26369TH Recombinant Human GRK5 N/A Inquiry
    Human GRK5-324H Recombinant Human GRK5, GST-tagged, Active Sf9 Insect Cell GST Inquiry
    Human GRK5-760H Recombinant Human GRK5, His tagged Insect Cell His
    Rat GRK5-2712R Recombinant Rat GRK5 Protein Mammalian Cell His Inquiry
    Zebrafish GRK5-7708Z Recombinant Zebrafish GRK5 Mammalian Cell His Inquiry
    Human GRK5-640HCL Recombinant Human GRK5 cell lysate Insect Cell N/A Inquiry
    Rat GRK5-2366R Recombinant Rat GRK5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human GRK5-1735H Recombinant Human GRK5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human GRK5-2359H Recombinant Human GRK5 Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human GRK5-5356H Recombinant Human GRK5 Protein, GST-tagged Wheat Germ GST Inquiry
    Mouse Grk5-1051M Recombinant Mouse Grk5 Protein, MYC/DDK-tagged HEK293T MYC/DDK Inquiry

    GRK5 involved in several pathways and played different roles in them. We selected most pathways GRK5 participated on our site, such as Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chemokine signaling pathway CCL3L1; RAP1B; WAS; GNB3; Adcy4; PIK3CB; CCL1; RLN1; CCL3L3; NRAS

    GRK5 has several biochemical functions, for example, ATP binding, G-protein coupled receptor kinase activity, beta-adrenergic receptor kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRK5 itself. We selected most functions GRK5 had, and list some proteins which have the same functions with GRK5. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor kinase activity GRK1A; GRK7; GRK6; GRK5; GRK1; RLN1; GRK7A; GRK7B; GRK1B; ADRBK2
    beta-adrenergic receptor kinase activity GRK6; GRK5; ADRBK2; ADRBK1
    phospholipid binding OTC; NOXO1; PLEKHA3; APOE; GOT2; PTAFR; NBEAA; NBEAL2; LC3; OSBPL1A
    protein binding MAPT; UCHL1; HBP1; USP5; IFIT3; APOBEC3H; MMS22L; TLE2; PARK7; SLC25A5
    protein kinase C binding DACT2; HDAC7; DSP; SDPRB; HDAC9; ADAM9; FLNA; PICK1; GNB2L1; UGT1A7
    protein serine/threonine kinase activity TAOK2; TAF1L; TBK1; KALRN; GRK1B; GSK3B; PLK2; STRC; BMPR1BB; HIPK2

    GRK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRK5.

    Htr4; ARRB1

    Mann, A; Illing, S; et al. Different mechanisms of homologous and heterologous mu-opioid receptor phosphorylation. BRITISH JOURNAL OF PHARMACOLOGY 172:311-316(2015).
    Doll, C; Poll, F; et al. Deciphering mu-opioid receptor phosphorylation and dephosphorylation in HEK293 cells. BRITISH JOURNAL OF PHARMACOLOGY 167:1259-1270(2012).

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