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GRK5

  • Official Full Name

    G protein-coupled receptor kinase 5

  • Overview

    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).
  • Synonyms

    GRK5; G protein-coupled receptor kinase 5; GPRK5; FP2025; g protein-coupled receptor kinase GRK5; FLJ39780;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRK5-1410H Active Recombinant Human GRK5, GST-tagged Sf9 Insect Cell GST Full length
Human GRK5-75HFL Active Recombinant Full Length Human GRK5 Protein, N-His-tagged Sf21 His Full Length
Human GRK5-324H Recombinant Human GRK5, GST-tagged, Active Sf9 Insect Cell GST
Human GRK5-26369TH Recombinant Human GRK5 N/A
Human GRK5-760H Recombinant Human GRK5 protein(Met1-Ser590), His-tagged Insect Cells C-His Met1-Ser590
Human GRK5-13541H Recombinant Human GRK5, His-tagged E.coli His 186-590a.a.
Human GRK5-640HCL Recombinant Human GRK5 cell lysate Insect Cell N/A
Human GRK5-5356H Recombinant Human GRK5 Protein, GST-tagged Wheat Germ GST
Human GRK5-2359H Recombinant Human GRK5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GRK5-1735H Recombinant Human GRK5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Grk5-1051M Recombinant Mouse Grk5 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat GRK5-2712R Recombinant Rat GRK5 Protein Mammalian Cell His
Rat GRK5-2366R Recombinant Rat GRK5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GRK5-2366R-B Recombinant Rat GRK5 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish GRK5-7708Z Recombinant Zebrafish GRK5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GRK5 Related Articles
  • GRK5 Related Research Area
  • GRK5 Related Signal Pathway

GRK5 involved in several pathways and played different roles in them. We selected most pathways GRK5 participated on our site, such as Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine signaling pathwayRHOA;CCL24;CCL16;IL-8;PLCB3;Ccl21c;CXCL6;IKBKB;Ccl27a
EndocytosisGRK1B;CYTH1A;SNX5;ADRB3A;SRC;HSPA2;HRASA;SNX1B;STAMBPB

GRK5 has several biochemical functions, for example, ATP binding, G-protein coupled receptor kinase activity, beta-adrenergic receptor kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRK5 itself. We selected most functions GRK5 had, and list some proteins which have the same functions with GRK5. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATAD1B;SPHK1;MAPK14;FARSA;TNK2B;MYO18A;MASTL;CTPS2;MYO1H
G-protein coupled receptor kinase activityGRK7;GRK1;RLN1;GRK7B;GRK7A;GRK4;GRK1B;ADRBK1;GRK6
beta-adrenergic receptor kinase activityADRBK2;GRK6;ADRBK1;GRK5
phospholipid bindingBAIAP2L2;PICALMA;FABP1;SPTBN1;OSBPL1A;APOA2;SYTL4;NSFL1C;SYT14
protein bindingTAF7;UNC45A;GATSL3;CRABP2;TEF;C19orf57;TCTEX1D1;SCO1;SH2D1B
protein kinase C bindingDSP;SQSTM1;PARD6A;PAWR;TDG;AVPR1B;PEA15A;HSPB1;PKN1
protein serine/threonine kinase activityTRIOA;NUAK1;PRPF4B;PRKCQ;DYRK4;DYRK1A;STK39;STK24;TSSK3

GRK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRK5.

Htr4; ARRB1

Mann, A; Illing, S; et al. Different mechanisms of homologous and heterologous mu-opioid receptor phosphorylation. BRITISH JOURNAL OF PHARMACOLOGY 172:311-316(2015).
Doll, C; Poll, F; et al. Deciphering mu-opioid receptor phosphorylation and dephosphorylation in HEK293 cells. BRITISH JOURNAL OF PHARMACOLOGY 167:1259-1270(2012).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What therapeutic strategies are being explored involving GRK5 modulation? 08/21/2022

Strategies include developing GRK5 inhibitors for potential use in heart disease and Alzheimer’s.

Are there known genetic mutations in GRK5 associated with specific health conditions? 04/16/2022

Certain GRK5 polymorphisms are associated with hypertension and heart failure risk.

How is GRK5 implicated in neurodegenerative diseases? 09/06/2021

GRK5 has been linked to Alzheimer’s disease through its role in tau phosphorylation.

How does GRK5 regulate G protein-coupled receptor (GPCR) activity? 05/04/2020

It phosphorylates activated GPCRs, promoting β-arrestin binding and receptor internalization.

In which tissues or cell types is GRK5 predominantly expressed? 01/23/2020

GRK5 is widely expressed but has notable levels in the heart and brain.

What role does GRK5 play in cardiovascular function? 01/08/2020

It regulates cardiac contractility and blood pressure, influencing heart function.

What is the main function of GRK5 in cellular signaling? 04/06/2019

GRK5 phosphorylates and desensitizes GPCRs, modulating their signaling.

Customer Reviews (3)

Write a review
Reviews
09/06/2021

    Good product, fast delivery.

    05/08/2021

      Highly recommend, very satisfied.

      03/05/2021

        Worked perfectly, great quality.

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