GRK5
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Official Full Name
G protein-coupled receptor kinase 5
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Overview
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). -
Synonyms
GRK5; G protein-coupled receptor kinase 5; GPRK5; FP2025; g protein-coupled receptor kinase GRK5; FLJ39780;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Insect Cells
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- GRK5 Related Articles
- GRK5 Related Research Area
- GRK5 Related Signal Pathway
GRK5 involved in several pathways and played different roles in them. We selected most pathways GRK5 participated on our site, such as Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Chemokine signaling pathway | RHOA;CCL24;CCL16;IL-8;PLCB3;Ccl21c;CXCL6;IKBKB;Ccl27a |
Endocytosis | GRK1B;CYTH1A;SNX5;ADRB3A;SRC;HSPA2;HRASA;SNX1B;STAMBPB |
GRK5 has several biochemical functions, for example, ATP binding, G-protein coupled receptor kinase activity, beta-adrenergic receptor kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRK5 itself. We selected most functions GRK5 had, and list some proteins which have the same functions with GRK5. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | ATAD1B;SPHK1;MAPK14;FARSA;TNK2B;MYO18A;MASTL;CTPS2;MYO1H |
G-protein coupled receptor kinase activity | GRK7;GRK1;RLN1;GRK7B;GRK7A;GRK4;GRK1B;ADRBK1;GRK6 |
beta-adrenergic receptor kinase activity | ADRBK2;GRK6;ADRBK1;GRK5 |
phospholipid binding | BAIAP2L2;PICALMA;FABP1;SPTBN1;OSBPL1A;APOA2;SYTL4;NSFL1C;SYT14 |
protein binding | TAF7;UNC45A;GATSL3;CRABP2;TEF;C19orf57;TCTEX1D1;SCO1;SH2D1B |
protein kinase C binding | DSP;SQSTM1;PARD6A;PAWR;TDG;AVPR1B;PEA15A;HSPB1;PKN1 |
protein serine/threonine kinase activity | TRIOA;NUAK1;PRPF4B;PRKCQ;DYRK4;DYRK1A;STK39;STK24;TSSK3 |
GRK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRK5.
Htr4; ARRB1
- Q&As
- Reviews
Q&As (7)
Ask a questionStrategies include developing GRK5 inhibitors for potential use in heart disease and Alzheimer’s.
Certain GRK5 polymorphisms are associated with hypertension and heart failure risk.
GRK5 has been linked to Alzheimer’s disease through its role in tau phosphorylation.
It phosphorylates activated GPCRs, promoting β-arrestin binding and receptor internalization.
GRK5 is widely expressed but has notable levels in the heart and brain.
It regulates cardiac contractility and blood pressure, influencing heart function.
GRK5 phosphorylates and desensitizes GPCRs, modulating their signaling.
Customer Reviews (3)
Write a reviewGood product, fast delivery.
Highly recommend, very satisfied.
Worked perfectly, great quality.
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