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Recombinant Human GRK5, His-tagged

Cat.No. : GRK5-13541H
Product Overview : Recombinant Human GRK5 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
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Description : Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Source : E.coli
Species : Human
Tag : His
Protein length : 186-590a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : GRK5 G protein-coupled receptor kinase 5 [ Homo sapiens ]
Official Symbol : GRK5
Synonyms : GRK5; G protein-coupled receptor kinase 5; GPRK5; FP2025; g protein-coupled receptor kinase GRK5; FLJ39780;
Gene ID : 2869
mRNA Refseq : NM_005308
Protein Refseq : NP_005299
MIM : 600870
UniProt ID : P34947
Chromosome Location : 10q24-qter
Pathway : Alpha-synuclein signaling, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; G alpha (q) signalling events, organism-specific biosystem;
Function : ATP binding; G-protein coupled receptor kinase activity; nucleotide binding; phospholipid binding; protein binding; protein kinase C binding; protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What therapeutic strategies are being explored involving GRK5 modulation? 08/21/2022

Strategies include developing GRK5 inhibitors for potential use in heart disease and Alzheimer’s.

Are there known genetic mutations in GRK5 associated with specific health conditions? 04/16/2022

Certain GRK5 polymorphisms are associated with hypertension and heart failure risk.

How is GRK5 implicated in neurodegenerative diseases? 09/06/2021

GRK5 has been linked to Alzheimer’s disease through its role in tau phosphorylation.

How does GRK5 regulate G protein-coupled receptor (GPCR) activity? 05/04/2020

It phosphorylates activated GPCRs, promoting β-arrestin binding and receptor internalization.

In which tissues or cell types is GRK5 predominantly expressed? 01/23/2020

GRK5 is widely expressed but has notable levels in the heart and brain.

What role does GRK5 play in cardiovascular function? 01/08/2020

It regulates cardiac contractility and blood pressure, influencing heart function.

What is the main function of GRK5 in cellular signaling? 04/06/2019

GRK5 phosphorylates and desensitizes GPCRs, modulating their signaling.

Customer Reviews (3)

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Reviews
09/06/2021

    Good product, fast delivery.

    05/08/2021

      Highly recommend, very satisfied.

      03/05/2021

        Worked perfectly, great quality.

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