Recombinant Human GRK5, His-tagged
Cat.No. : | GRK5-13541H |
Product Overview : | Recombinant Human GRK5 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Description : | Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | 186-590a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | GRK5 G protein-coupled receptor kinase 5 [ Homo sapiens ] |
Official Symbol : | GRK5 |
Synonyms : | GRK5; G protein-coupled receptor kinase 5; GPRK5; FP2025; g protein-coupled receptor kinase GRK5; FLJ39780; |
Gene ID : | 2869 |
mRNA Refseq : | NM_005308 |
Protein Refseq : | NP_005299 |
MIM : | 600870 |
UniProt ID : | P34947 |
Chromosome Location : | 10q24-qter |
Pathway : | Alpha-synuclein signaling, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; G alpha (q) signalling events, organism-specific biosystem; |
Function : | ATP binding; G-protein coupled receptor kinase activity; nucleotide binding; phospholipid binding; protein binding; protein kinase C binding; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
GRK5-2359H | Recombinant Human GRK5 Protein, MYC/DDK-tagged | +Inquiry |
GRK5-2366R | Recombinant Rat GRK5 Protein, His (Fc)-Avi-tagged | +Inquiry |
Grk5-1051M | Recombinant Mouse Grk5 Protein, MYC/DDK-tagged | +Inquiry |
GRK5-760H | Recombinant Human GRK5 protein(Met1-Ser590), His-tagged | +Inquiry |
GRK5-5356H | Recombinant Human GRK5 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
GRK5-640HCL | Recombinant Human GRK5 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionStrategies include developing GRK5 inhibitors for potential use in heart disease and Alzheimer’s.
Certain GRK5 polymorphisms are associated with hypertension and heart failure risk.
GRK5 has been linked to Alzheimer’s disease through its role in tau phosphorylation.
It phosphorylates activated GPCRs, promoting β-arrestin binding and receptor internalization.
GRK5 is widely expressed but has notable levels in the heart and brain.
It regulates cardiac contractility and blood pressure, influencing heart function.
GRK5 phosphorylates and desensitizes GPCRs, modulating their signaling.
Customer Reviews (3)
Write a reviewGood product, fast delivery.
Highly recommend, very satisfied.
Worked perfectly, great quality.
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