guca1a
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  • Official Full Name
  • guanylate cyclase activator 1A (retina)
  • Background
  • This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia.
  • Synonyms
  • GUCA1A; guanylate cyclase activator 1A (retina); C6orf131, chromosome 6 open reading frame 131 , GUCA, GUCA1; guanylyl cyclase-activating protein 1; COD3; cone dystrophy 3; dJ139D8.6; GCAP; GCAP1; GCAP 1; guanylin 1, retina; guanylate cyclase-activating
Cat.#:GUCA1A-2549HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GUCA1A Protein, MYC/DDK-tagged
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Cat.#:GUCA1A-4482HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GUCA1A Protein, GST-tagged
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Cat.#:GUCA1A-28157THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GUCA1A
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Cat.#:GUCA1A-407HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GUCA1A, Gly & Pro tagged
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Cat.#:GUCA1A-487HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GUCA1A, His-GST tagged
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Cat.#:GUCA1A-7383MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GUCA1A Protein
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Cat.#:GUCA1A-5893CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GUCA1A
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Cat.#:GUCA1A-9374ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GUCA1A
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Cat.#:GUCA1A-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GUCA1A cell lysate
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Cat.#:GUCA1A-002HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GUCA1A cell lysate
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Involved Pathway

GUCA1A involved in several pathways and played different roles in them. We selected most pathways GUCA1A participated on our site, such as Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUCA1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phototransduction
RCVRN; GUCY2E; CALM4; CALML5; SAGA; CALM2A; GRK7B; PDE6B; RCV1; PDE6A

Protein Function

GUCA1A has several biochemical functions, for example, calcium ion binding, calcium sensitive guanylate cyclase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GUCA1A itself. We selected most functions GUCA1A had, and list some proteins which have the same functions with GUCA1A. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein NUCB2B; CANT1; PPP3CB; OCM2; THBS4A; PCDH12; FBN1; CALM4; EFEMP1; ANXA5B
Function calcium sensitive guanylate cyclase activator activity
Related Protein GUCA1G; GUCA1C; GUCA1B; GUCA1D; GUCA1E; RCVRN; GUCA1A; GUCA2B

Interacting Protein

GUCA1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUCA1A here. Most of them are supplied by our site. Hope this information will be useful for your research of GUCA1A.
HSPB1

GUCA1A Related Articles

Zobor, D; Zrenner, E; et al. GUCY2D- OR GUCA1A-RELATED AUTOSOMAL DOMINANT CONE-ROD DYSTROPHY Is There a Phenotypic Difference?. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 34:1576-1587(2014).
Lopez-del Hoyo, N; Lopez-Begines, S; et al. Functional EF-Hands in Neuronal Calcium Sensor GCAP2 Determine Its Phosphorylation State and Subcellular Distribution In Vivo, and Are Essential for Photoreceptor Cell Integrity. PLOS GENETICS 10:-(2014).