Recombinant Human GUCA1A Protein, GST-tagged
Cat.No. : | GUCA1A-4482H |
Product Overview : | Human GUCA1A full-length ORF ( AAH31663, 1 a.a. - 201 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. [provided by RefSeq |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 47.85 kDa |
AA Sequence : | MGNVMEGKSVEELSSTECHQWYKKF MTECPSGQLTLYEFRQFFGLKNLSP SASQYVEQMFETFDFNKDGYIDFME YVAALSLVLKGKVEQKLRWYFKLYD VDGNGCIDRDELLTIIQAIRAINPC SDTTMTAEEFTDTVFSKIDVNGDGE LSLEEFIEGVQKDQMLLDTLTRSLD LTRIVRRLQNGEQDEEGADEAAEAA G |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | GUCA1A guanylate cyclase activator 1A (retina) [ Homo sapiens ] |
Official Symbol : | GUCA1A |
Synonyms : | GUCA1A; guanylate cyclase activator 1A (retina); C6orf131, chromosome 6 open reading frame 131 , GUCA, GUCA1; guanylyl cyclase-activating protein 1; COD3; cone dystrophy 3; dJ139D8.6; GCAP; GCAP1; GCAP 1; guanylin 1, retina; guanylate cyclase-activating protein, photoreceptor 1; GUCA; GUCA1; CORD14; C6orf131; |
Gene ID : | 2978 |
mRNA Refseq : | NM_000409 |
Protein Refseq : | NP_000400 |
MIM : | 600364 |
UniProt ID : | P43080 |
Products Types
◆ Recombinant Protein | ||
GUCA1A-4006M | Recombinant Mouse GUCA1A Protein, His (Fc)-Avi-tagged | +Inquiry |
GUCA1A-2549H | Recombinant Human GUCA1A Protein, MYC/DDK-tagged | +Inquiry |
GUCA1A-7383M | Recombinant Mouse GUCA1A Protein | +Inquiry |
GUCA1A-1989H | Recombinant Human GUCA1A protein | +Inquiry |
GUCA1A-28157TH | Recombinant Human GUCA1A | +Inquiry |
◆ Lysates | ||
GUCA1A-001HCL | Recombinant Human GUCA1A cell lysate | +Inquiry |
GUCA1A-002HCL | Recombinant Human GUCA1A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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