|Official Full Name||heart and neural crest derivatives expressed 1|
|Background||The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]|
|Synonyms||HAND1; heart and neural crest derivatives expressed 1; Hxt; eHand; Thing1; bHLHa27; heart- and neural crest derivatives-expressed protein 1; class A basic helix-loop-helix protein 27; extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
hand1 involved in several pathways and played different roles in them. We selected most pathways hand1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with hand1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Signaling pathways regulating pluripotency of stem cells||GSK3B; WNT6; AKT2; WNT7B; LHX5; BMI1; SMARCAD1; SKIL; WNT2; ESRRB|
hand1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, bHLH transcription factor binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hand1 itself. We selected most functions hand1 had, and list some proteins which have the same functions with hand1. You can find most of the proteins on our site.
|RNA polymerase II core promoter proximal region sequence-specific DNA binding||MESP1; MYPOP; POU4F3; NPAS4; CC2D1B; HLTF; SMAD2; MZF1; MITFA; DLX4|
|bHLH transcription factor binding||ISL1; TCF3B; MAP3K10; SP1; EP300; TCF12; TWIST1; USF2; USF1; HAND1|
|enzyme binding||CBX1; GSTM4; FAM84B; CALU; TBP; PLCB1; Ar; IQCB1; MDM2; AXIN2|
|identical protein binding||CAV1; PYDC3; LYZ1; CLDN4; USP15; CEACAM5; CAD; CLDN20; DLC; LCK|
|protein binding||FIBPB; WIF1; SLC4A1AP; HIST1H4A; CHMP4B; BCL6; IRF9; ASB3; CDK5R2; GRIP1|
|protein heterodimerization activity||TPD52; SFRP5; GRIN1; ADORA1; TAF9B; CENPW; NEFH; RXRA; IRAK1; HER5|
|protein homodimerization activity||NR6A1; CDH13; GSTA4; ASGR1; S100B; ADD1; RAB11FIP4B; UGT1A6; PLDN; CD4|
|transcription coactivator activity||ECD; HINFP; USP16; TAF10; NEUROD1; MAK; BRDT; TADA3; JUPA; MYOD1|
|transcription corepressor activity||HIRA; NR0B1; SMYD1; SAP30; DDX54; TBL1XR1A; ZNF593; MSC; KCTD1; WNT4|
|transcription factor binding||NCOR2; KEAP1; PSMD4; CRY1; SORBS3; JUN; APBB2; EGR1; HDAC11; PRICKLE1|
|contributes_to transcription regulatory region DNA binding||TCF12; RXRA; NFYB; HAND1; NFYC; TAF1; NFYA; NR1H3; HDAC4; ATF4|
|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding||ZFPM1; GATA1; ZFPM2; NR1D1; CC2D1A; KLF16; HAND1; NFATC4; ATF3; NFIL3-6|
hand1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hand1 here. Most of them are supplied by our site. Hope this information will be useful for your research of hand1.