hand1

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hand1

Official Full Name heart and neural crest derivatives expressed 1
Background The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]
Synonyms HAND1; heart and neural crest derivatives expressed 1; Hxt; eHand; Thing1; bHLHa27; heart- and neural crest derivatives-expressed protein 1; class A basic helix-loop-helix protein 27; extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HAND1-13662H Recombinant Human HAND1, GST-tagged E.coli GST
    Human HAND1-4566H Recombinant Human HAND1 Protein, GST-tagged Wheat Germ GST
    Human HAND1-5639HCL Recombinant Human HAND1 293 Cell Lysate HEK293 N/A
    Human HAND1-7171H Recombinant Human Heart And Neural Crest Derivatives Expressed 1, His-tagged E.coli His
    Mouse Hand1-7851M Recombinant Mouse Hand1 protein, His & T7-tagged E.coli His/T7
    Rat HAND1-2786R Recombinant Rat HAND1 Protein Mammalian Cell His
    Chicken HAND1-6524C Recombinant Chicken HAND1 Mammalian Cell His

    hand1 involved in several pathways and played different roles in them. We selected most pathways hand1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with hand1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling pathways regulating pluripotency of stem cells GSK3B; WNT6; AKT2; WNT7B; LHX5; BMI1; SMARCAD1; SKIL; WNT2; ESRRB

    hand1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, bHLH transcription factor binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hand1 itself. We selected most functions hand1 had, and list some proteins which have the same functions with hand1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding MESP1; MYPOP; POU4F3; NPAS4; CC2D1B; HLTF; SMAD2; MZF1; MITFA; DLX4
    bHLH transcription factor binding ISL1; TCF3B; MAP3K10; SP1; EP300; TCF12; TWIST1; USF2; USF1; HAND1
    enzyme binding CBX1; GSTM4; FAM84B; CALU; TBP; PLCB1; Ar; IQCB1; MDM2; AXIN2
    identical protein binding CAV1; PYDC3; LYZ1; CLDN4; USP15; CEACAM5; CAD; CLDN20; DLC; LCK
    protein binding FIBPB; WIF1; SLC4A1AP; HIST1H4A; CHMP4B; BCL6; IRF9; ASB3; CDK5R2; GRIP1
    protein heterodimerization activity TPD52; SFRP5; GRIN1; ADORA1; TAF9B; CENPW; NEFH; RXRA; IRAK1; HER5
    protein homodimerization activity NR6A1; CDH13; GSTA4; ASGR1; S100B; ADD1; RAB11FIP4B; UGT1A6; PLDN; CD4
    transcription coactivator activity ECD; HINFP; USP16; TAF10; NEUROD1; MAK; BRDT; TADA3; JUPA; MYOD1
    transcription corepressor activity HIRA; NR0B1; SMYD1; SAP30; DDX54; TBL1XR1A; ZNF593; MSC; KCTD1; WNT4
    transcription factor binding NCOR2; KEAP1; PSMD4; CRY1; SORBS3; JUN; APBB2; EGR1; HDAC11; PRICKLE1
    contributes_to transcription regulatory region DNA binding TCF12; RXRA; NFYB; HAND1; NFYC; TAF1; NFYA; NR1H3; HDAC4; ATF4
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ZFPM1; GATA1; ZFPM2; NR1D1; CC2D1A; KLF16; HAND1; NFATC4; ATF3; NFIL3-6

    hand1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hand1 here. Most of them are supplied by our site. Hope this information will be useful for your research of hand1.

    Org, T; Duan, D; et al. Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. EMBO JOURNAL 34:759-777(2015).
    Li, D; Ji, L; et al. Characterization of Circulating MicroRNA Expression in Patients with a Ventricular Septal Defect. PLOS ONE 9:-(2014).

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