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HAVCR2

Official Full Name

hepatitis A virus cellular receptor 2
Background

Tim-3 is a transmembrane protein also known as T cell immunoglobulin and musin domain containing protein-3. Tim-3 is expressed at high levels on Th1 lymphocytes and CD11b<sup>+</sup>macrophages. Tim-3 has also been shown to exist as a soluble protein. Cel
Synonyms

HAVCR2; hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; TIM-3; TIMD-3; HAVcr-2; T-cell membrane protein 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; tim3;

Type:
Recombinant Proteins
Cell & Tissue Lysates
Antibody
GMP Proteins
Protein Pre-coupled Magnetic Beads

Species :
Canine
Cynomolgus
Cynomolgus monkey
Cynomolgus Monkey
Human
Monkey
Mouse

Source :
CHO
CHO cells
E.coli
HEK293
HEK293F
Human Cell
Insect Cell
Mammalian cells
NS0
Rabbit
Wheat Germ
Yeast

Tag :
DDK|His
Fc
Fc Chimera
His
Fc|His
Avi
His(C
ter)
GST
hFc
HIgG
hIgG
His (Fc)
His|Avi
human|IgG1|Fc
mFc
N/A
N
Strep
T7|His

Species	Cat.#	Product name	Source (Host)	Tag	Price
Canine	HAVCR2-0760C	Recombinant Canine HAVCR2 protein, His-tagged	HEK293	His	Inquiry
Cynomolgus	HAVCR2-0761C	Recombinant Cynomolgus HAVCR2 protein, Fc-tagged	HEK293	Fc	Inquiry
Cynomolgus	HAVCR2-682C	Recombinant Cynomolgus HAVCR2 protein, His-tagged	HEK293	His	Inquiry
Cynomolgus Monkey	HAVCR2-540C	Active Recombinant Cynomolgus Monkey HAVCR2, Fc Chimera	HEK293	Fc Chimera	Inquiry
Cynomolgus Monkey	HAVCR2-001CCL	Recombinant Cynomolgus HAVCR2 cell lysate	Human Cell	N/A	Inquiry
Cynomolgus monkey	HAVCR2-734C	Recombinant Cynomolgus monkey HAVCR2 Protein, Fc-tagged	HEK293	Fc	Inquiry
Cynomolgus Monkey	HAVCR2-213C	Recombinant Cynomolgus HAVCR2, Fc-tagged	Human Cell	Fc	$498.00 / 50µg
Human	HAVCR2-878H	Recombinant Human HAVCR2 protein, Strep-tagged	HEK293	Strep	Inquiry
Human	HAVCR2-02H	Recombinant Human HAVCR2 Protein, hIgG-His-Tagged	Insect Cell	HIgG/His	Inquiry
Human	CAB11553RH	Rabbit Anti-Human TIMD3 / HAVCR2 Monoclonal Antibody	Rabbit	N/A	Inquiry
Human	HAVCR2-7093H	Recombinant Human HAVCR2, His-tagged	E.coli	His	Inquiry
Human	HAVCR2-051H	Active Recombinant Human HAVCR2 protein, His/Avi-tagged, Biotinylated	CHO cells	His/Avi	Inquiry
Human	HAVCR2-455H	Recombinant Human HAVCR2 Protein, Fc-tagged	HEK293	Fc	Inquiry
Human	HAVCR2-513H	Recombinant Human HAVCR2, Fc-tagged	CHO	Fc	Inquiry
Human	HAVCR2-217H	Active Recombinant Human HAVCR2, MIgG2a Fc-tagged	CHO	Fc	Inquiry
Human	HAVCR2-706H	Active Recombinant Human HAVCR2(Ser22-Arg200) Protein, C-Fc-Avi-tagged, Biotinylated	HEK293	Fc-Avi	Inquiry
Human	HAVCR2-735H	Recombinant Human HAVCR2 Protein, Fc-tagged	HEK293	Fc	Inquiry
Human	HAVCR2-3166H	Active Recombinant Human HAVCR2, His tagged	HEK293	His	$786.00 / 100µg
Human	HAVCR2-704H	Active Recombinant Human HAVCR2, Fc-tagged, Biotinylated	Human Cell	Fc	Inquiry
Human	HAVCR2-3019H	Recombinant Human HAVCR2 protein, His-tagged	E.coli	His	Inquiry
Human	HAVCR2-877HAF555	Recombinant Human HAVCR2 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated	HEK293	Fc/His	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Human	HAVCR2-876H	Recombinant Human HAVCR2 protein, Fc-tagged	HEK293	human/IgG1/Fc	$798.00 / 100µg
Human	HAVCR2-4591H	Recombinant Human HAVCR2 Protein, GST-tagged	Wheat Germ	GST	Inquiry
Human	HAVCR2-877HAF488	Recombinant Human HAVCR2 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated	HEK293	Fc/His	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Human	HAVCR2-956H	Recombinant Human HAVCR2 Protein, His-tagged	HEK293F	N-His	Inquiry
Human	HAVCR2-515H	Active Recombinant Human HAVCR2 Protein, His-tagged	CHO	His	Inquiry
Human	HAVCR2-2023H	Recombinant Human HAVCR2 Protein, His-tagged	HEK293	His	Inquiry
Human	HAVCR2-5422H	Recombinant Human HAVCR2 protein, His-tagged	Yeast	His	Inquiry
Human	HAVCR2-111H	Recombinant Human HAVCR2 Protein (ECD), His-tagged(C-ter)	HEK293	His(C-ter)	Inquiry
Human	HAVCR2-439H	Recombinant Human HAVCR2 Protein, DDK/His-tagged	HEK293	DDK/His	Inquiry
Human	HAVCR2-371H	Recombinant Human HAVCR2 protein, Fc-tagged	HEK293	human/IgG1/Fc	Inquiry
Human	HAVCR2-110H	Recombinant Human HAVCR2 Protein (ECD), Fc-His-tagged(C-ter)	HEK293	Fc-His(C-ter)	Inquiry
Human	HAVCR2-877H	Recombinant Human HAVCR2, Fc-His tagged	Human Cell	Fc/His	$798.00 / 100µg
Human	HAVCR2-367H	Recombinant Human HAVCR2 protein, mFc-tagged	HEK293	mFc	Inquiry
Human	HAVCR2-3166HAF555	Recombinant Human HAVCR2 Protein, His-tagged, Alexa Fluor 555 conjugated	HEK293	His	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Human	HAVCR2-736H	Recombinant Human HAVCR2 Protein, Strep-tagged	HEK293	Strep	Inquiry
Human	HAVCR2-219H	Active Recombinant Human HAVCR2, HIgG1 Fc-tagged	CHO	Fc	Inquiry
Human	HAVCR2-2670H	Recombinant Human HAVCR2 protein, His-tagged	E.coli	His	$319.00 / 25ug
Human	HAVCR2-3166HAF647	Recombinant Human HAVCR2 Protein, His-tagged, Alexa Fluor 647 conjugated	HEK293	His	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Human	HAVCR2-737H	Recombinant Human HAVCR2 Protein	HEK293		Inquiry
Human	HAVCR2-218H	Active Recombinant Human Hepatitis A Virus Cellular Receptor 2, HIgG1 Fc-tagged	CHO	Fc	Inquiry
Human	HAVCR2-3166HAF488	Recombinant Human HAVCR2 Protein, His-tagged, Alexa Fluor 488 conjugated	HEK293	His	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Human	HAVCR2-3166HF	Recombinant Human HAVCR2 Protein, His-tagged, FITC conjugated	HEK293	His	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Human	HAVCR2-1454H	Recombinant Human HAVCR2 Protein (Ser22-Arg200), N-His tagged	E.coli	N-His	Inquiry
Human	HAVCR2-175H	Recombinant Human HAVCR2 protein, T7/His-tagged	E.coli	T7/His	Inquiry
Human	HAVCR2-5025H	Recombinant Human HAVCR2 protein, hFc-tagged	HEK293	hFc	Inquiry
Human	HAVCR2-877HF	Recombinant Human HAVCR2 Protein, Fc/His-tagged, FITC conjugated	HEK293	Fc/His	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Human	HAVCR2-0764H	Recombinant Human HAVCR2 protein, Fc-tagged	HEK293	Fc	Inquiry
Human	HAVCR2-514H	Active Recombinant Human HAVCR2 Protein, Fc-tagged	CHO	Fc	Inquiry
Human	HAVCR2-877HAF647	Recombinant Human HAVCR2 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated	HEK293	Fc/His	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Human	HAVCR2-01H	Recombinant Human HAVCR2 Protein, Fc-Tagged	NS0	Fc	Inquiry
Human	HAVCR2-440H	Recombinant Human HAVCR2 Protein, Fc/His-tagged	HEK293	Fc/His	Inquiry
Human	HAVCR2-149H	Recombinant Human HAVCR2 Protein, His-tagged	E.coli	His	Inquiry
Human	HAVCR2-705H	Recombinant Human HAVCR2 Protein, His-Avi-tagged, Biotinylated	HEK293	His/Avi	$799.00 / 25µg
Human	HAVCR2-2610H	Recombinant Human HAVCR2 protein, His-tagged	HEK293	His	Inquiry
Human	HAVCR2-023HG	GMP Recombinant Human HAVCR2 protein, Fc-tagged	HEK293	Fc	Inquiry
Human	HAVCR2-1246H	Recombinant Human HAVCR2 protein, hFc&His-tagged	HEK293	hFc&His	Inquiry
Human	HAVCR2-3166HB	Recombinant Human HAVCR2 protein, His-tagged, Biotinylated	HEK293	His	Inquiry
Monkey	HAVCR2-213CAF555	Recombinant Monkey HAVCR2 Protein, Fc-tagged, Alexa Fluor 555 conjugated	HEK293	Fc	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Monkey	HAVCR2-213CAF488	Recombinant Monkey HAVCR2 Protein, Fc-tagged, Alexa Fluor 488 conjugated	HEK293	Fc	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Monkey	HAVCR2-213CAF647	Recombinant Monkey HAVCR2 Protein, Fc-tagged, Alexa Fluor 647 conjugated	HEK293	Fc	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Monkey	HAVCR2-213CF	Recombinant Monkey HAVCR2 Protein, Fc-tagged, FITC conjugated	HEK293	Fc	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Mouse	HAVCR2-738M	Recombinant Mouse HAVCR2 Protein	HEK293		Inquiry
Mouse	HAVCR2-319MAF555	Recombinant Mouse Havcr2 Protein, Fc-tagged, Alexa Fluor 555 conjugated	HEK293	Fc	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Mouse	Havcr2-112M	Recombinant Mouse HAVCR2 Protein (ECD), Fc-His-tagged(C-ter)	HEK293	Fc-His(C-ter)	Inquiry
Mouse	Havcr2-113M	Recombinant Mouse HAVCR2 Protein (ECD), His-tagged(C-ter)	HEK293	His(C-ter)	Inquiry
Mouse	HAVCR2-739M	Recombinant Mouse HAVCR2 Protein, Fc-tagged	HEK293	Fc	Inquiry
Mouse	HAVCR2-529MAF555	Recombinant Mouse Havcr2 Protein, His-tagged, Alexa Fluor 555 conjugated	HEK293	His	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Mouse	Havcr2-138M	Recombinant Mouse Havcr2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	$2,998.00 / 50ug
Mouse	HAVCR2-0762M	Recombinant Mouse HAVCR2 protein, His-tagged	HEK293	His	Inquiry
Mouse	HAVCR2-319MAF488	Recombinant Mouse Havcr2 Protein, Fc-tagged, Alexa Fluor 488 conjugated	HEK293	Fc	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Mouse	HAVCR2-319MF	Recombinant Mouse Havcr2 Protein, Fc-tagged, FITC conjugated	HEK293	Fc	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Mouse	HAVCR2-211M	Active Recombinant Mouse Hepatitis A Virus Cellular Receptor 2, MIgG2a Fc-tagged	CHO	Fc	Inquiry
Mouse	HAVCR2-995MCL	Recombinant Mouse HAVCR2 cell lysate	Human Cell	N/A	Inquiry
Mouse	HAVCR2-529MAF488	Recombinant Mouse Havcr2 Protein, His-tagged, Alexa Fluor 488 conjugated	HEK293	His	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Mouse	HAVCR2-529MF	Recombinant Mouse Havcr2 Protein, His-tagged, FITC conjugated	HEK293	His	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Mouse	HAVCR2-0763M	Recombinant Mouse HAVCR2 protein, Fc-tagged	HEK293	Fc	Inquiry
Mouse	Havcr2-397M	Active Recombinant Mouse Havcr2, Fc Chimera	Mammalian cells	Fc Chimera	Inquiry
Mouse	HAVCR2-319MAF647	Recombinant Mouse Havcr2 Protein, Fc-tagged, Alexa Fluor 647 conjugated	HEK293	Fc	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Mouse	HAVCR2-529MAF647	Recombinant Mouse Havcr2 Protein, His-tagged, Alexa Fluor 647 conjugated	HEK293	His	$798.00 / 20ug $1,298.00 / 50ug $1,998.00 / 100ug
Mouse	Havcr2-03M	Recombinant Mouse Havcr2 Protein, hIgG-His-tagged	HEK293	hIgG-His	Inquiry
Mouse	HAVCR2-319M	Recombinant Mouse Havcr2, Fc tagged	Human Cell	His	$498.00 / 50µg
Mouse	HAVCR2-529M	Recombinant Mouse Havcr2, His tagged	Human Cell	His	$498.00 / 50µg
Mouse	Havcr2-138M-B	Recombinant Mouse Havcr2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
HAVCR2 Related Articles
HAVCR2 Related Research Area

HAVCR2 involved in several pathways and played different roles in them. We selected most pathways HAVCR2 participated on our site, such as Cytokine Signaling in Immune system, Immune System, Interleukin-2 signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAVCR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cytokine Signaling in Immune system	SPRED2;FRS2B;SPRED3;BST2;DUSP5;EIF4A1;FGFR1B;CRK;CSHL1
Immune System	SIGLEC10;ASB4;WASF2;PANX1;CTSK;KLRG1;PCBP2;AP1B1;KIF20A
Interleukin-2 signaling	HAVCR2;LGALS9
Signaling by Interleukins	HAVCR2;CASPBL;CASPB;IL1RN;SOCS3A;LGALS9

HAVCR2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by HAVCR2 itself. We selected most functions HAVCR2 had, and list some proteins which have the same functions with HAVCR2. You can find most of the proteins on our site.

Function	Related Protein

HAVCR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAVCR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAVCR2.

Markwick, LJL; Riva, A; et al. Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients With Acute Alcoholic Hepatitis. GASTROENTEROLOGY 148:590-+(2015).

Sabahi, A; Uprichard, SL; et al. Unexpected Structural Features of the Hepatitis C Virus Envelope Protein 2 Ectodomain. JOURNAL OF VIROLOGY 88:10280-10288(2014).

Cancer Drug Targets

Immune Checkpoints

TIM Family Co-Signaling Molecules

Leukemia Cancer Stem Cell Markers