HAVCR2

  • Official Full Name

    hepatitis A virus cellular receptor 2

  • Overview

    Tim-3 is a transmembrane protein also known as T cell immunoglobulin and musin domain containing protein-3. Tim-3 is expressed at high levels on Th1 lymphocytes and CD11b<sup>+</sup>macrophages. Tim-3 has also been shown to exist as a soluble protein. Cel

  • Synonyms

    HAVCR2;hepatitis A virus cellular receptor 2;hepatitis A virus cellular receptor 2 homolog;TIM-3;TIMD-3;HAVcr-2;T-cell membrane protein 3;T cell immunoglobulin mucin-3;T-cell immunoglobulin and mucin domain-containing protein 3;tim3

Recombinant Proteins

  • Human
  • Cynomolgus
  • Mouse
  • Monkey
  • Canine
  • HEK293
  • Human Cells
  • Insect Cells
  • E.coli
  • CHO
  • Mammalian Cells
  • Wheat Germ
  • Rabbit
  • NS0
  • In Vitro Cell Free System
  • Yeast
  • His
  • Fc
  • Avi
  • T7
  • Flag
  • GST
  • Non
  • mFc
Cat.# Product name Source (Host) Species Tag Protein Length Price
HAVCR2-3166H Active Recombinant Human HAVCR2, His tagged HEK293 Human His Met1-Arg200
HAVCR2-213C Recombinant Cynomolgus HAVCR2 protein(Met1-Arg201), hFc-tagged HEK293 Cynomolgus Fc Met1-Arg201
HAVCR2-319M Recombinant Mouse HAVCR2 protein(Met1-Arg191), hFc-tagged HEK293 Mouse Fc 45310 a.a.
HAVCR2-529M Recombinant Mouse HAVCR2 protein, His-tagged HEK293 Mouse His Leu22-Arg191
HAVCR2-876H Recombinant Human HAVCR2 protein, Fc-tagged HEK293 Human Fc 179
HAVCR2-877H Recombinant Human HAVCR2, Fc-His tagged Human Cells Human Fc&His 1-200 a.a.
HAVCR2-02H Recombinant Human HAVCR2 Protein, hIgG-His-Tagged Insect Cells Human Fc&His 423aa
Havcr2-03M Recombinant Mouse Havcr2 Protein, hIgG-His-tagged HEK293 Mouse Fc&His
HAVCR2-213CAF488 Recombinant Monkey HAVCR2 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Monkey Fc Met1-Arg201， 418
HAVCR2-213CAF555 Recombinant Monkey HAVCR2 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Monkey Fc Met1-Arg201， 418
HAVCR2-213CAF647 Recombinant Monkey HAVCR2 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Monkey Fc Met1-Arg201， 418
HAVCR2-213CF Recombinant Monkey HAVCR2 Protein, Fc-tagged, FITC conjugated HEK293 Monkey Fc Met1-Arg201， 418
HAVCR2-2670H Recombinant Human HAVCR2 protein, His-tagged E.coli Human His 143 - 301 aa
HAVCR2-3166HAF488 Recombinant Human HAVCR2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Human His 190
HAVCR2-3166HAF555 Recombinant Human HAVCR2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Human His 190
HAVCR2-3166HAF647 Recombinant Human HAVCR2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Human His 190
HAVCR2-3166HF Recombinant Human HAVCR2 Protein, His-tagged, FITC conjugated HEK293 Human His 190
HAVCR2-319MAF488 Recombinant Mouse Havcr2 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Mouse Fc 411
HAVCR2-319MAF555 Recombinant Mouse Havcr2 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Mouse Fc 411
HAVCR2-319MAF647 Recombinant Mouse Havcr2 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Mouse Fc 411
HAVCR2-319MF Recombinant Mouse Havcr2 Protein, Fc-tagged, FITC conjugated HEK293 Mouse Fc 411
HAVCR2-529MAF488 Recombinant Mouse Havcr2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Mouse His 181
HAVCR2-529MAF555 Recombinant Mouse Havcr2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Mouse His 181
HAVCR2-529MAF647 Recombinant Mouse Havcr2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Mouse His 181
HAVCR2-529MF Recombinant Mouse Havcr2 Protein, His-tagged, FITC conjugated HEK293 Mouse His 181
HAVCR2-705H Active Recombinant Human HAVCR2 Protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His 22-200 a.a.
HAVCR2-877HAF488 Recombinant Human HAVCR2 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc&His 426
HAVCR2-877HAF555 Recombinant Human HAVCR2 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc&His 426
HAVCR2-877HAF647 Recombinant Human HAVCR2 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc&His 426
HAVCR2-877HF Recombinant Human HAVCR2 Protein, Fc/His-tagged, FITC conjugated HEK293 Human Fc&His 426
HAVCR2-211M Active Recombinant Mouse Hepatitis A Virus Cellular Receptor 2, MIgG2a Fc-tagged CHO Mouse Fc
HAVCR2-217H Active Recombinant Human HAVCR2, MIgG2a Fc-tagged CHO Human Fc
HAVCR2-218H Active Recombinant Human Hepatitis A Virus Cellular Receptor 2, HIgG1 Fc-tagged CHO Human Fc
HAVCR2-219H Active Recombinant Human HAVCR2, HIgG1 Fc-tagged CHO Human Fc
Havcr2-397M Active Recombinant Mouse Havcr2, Fc Chimera Mammalian Cells Mouse Fc
HAVCR2-514H Active Recombinant Human HAVCR2 Protein, Fc-tagged CHO Human Fc 22-202 a.a.
HAVCR2-515H Active Recombinant Human HAVCR2 Protein, His-tagged CHO Human His 22-202 a.a.
HAVCR2-540C Active Recombinant Cynomolgus Monkey HAVCR2, Fc Chimera HEK293 Cynomolgus Fc
HAVCR2-704H Active Recombinant Human HAVCR2, Fc-tagged, Biotinylated Human Cells Human Fc 22-202 a.a.
HAVCR2-051H Active Recombinant Human HAVCR2 protein, His/Avi-tagged, Biotinylated CHO Human Avi&His Ser22-Arg200
HAVCR2-0761C Active Recombinant Cynomolgus HAVCR2 protein, Fc-tagged HEK293 Cynomolgus Fc 22-201 a.a.
HAVCR2-0764H Active Recombinant Human HAVCR2 protein, Fc-tagged HEK293 Human Fc 22-200 a.a.
HAVCR2-3272H Active Recombinant Human HAVCR2 protein(Met1-Arg200), His-tagged, Biotinylated HEK293 Human His Met1-Arg200
HAVCR2-682C Active Recombinant Cynomolgus HAVCR2 protein, His-tagged HEK293 Cynomolgus His Ser 22 - Arg 201
HAVCR2-706H Active Recombinant Human HAVCR2(Ser22-Arg200) Protein, C-Fc-Avi-tagged, Biotinylated HEK293 Human Avi&Fc 22-200 a.a.
HAVCR2-175H Recombinant Human HAVCR2 protein, T7/His-tagged E.coli Human His&T7 22-202 a.a.
HAVCR2-439H Recombinant Human HAVCR2 Protein, DDK/His-tagged HEK293 Human Flag&His 23-200 a.a.
HAVCR2-440H Recombinant Human HAVCR2 Protein, Fc/His-tagged HEK293 Human Fc&His
HAVCR2-4591H Recombinant Human HAVCR2 Protein, GST-tagged Wheat Germ Human GST
HAVCR2-513H Recombinant Human HAVCR2, Fc-tagged CHO Human Fc
HAVCR2-7093H Recombinant Human HAVCR2, His-tagged E.coli Human His 22-202aa
HAVCR2-001CCL Recombinant Cynomolgus HAVCR2 cell lysate Human Cells Cynomolgus Non
HAVCR2-995MCL Recombinant Mouse HAVCR2 cell lysate Human Cells Mouse Non
CAB11553RH Rabbit Anti-Human TIMD3 / HAVCR2 Monoclonal Antibody Rabbit Human Non
HAVCR2-01H Active Recombinant Human HAVCR2 Protein, Fc-Tagged NS0 Human Fc
HAVCR2-023HG Active GMP Recombinant Human HAVCR2 protein, Fc-tagged HEK293 Human Fc DNA sequence encoding Human TIM3(NCBI Reference Sequence: NP_116171.3) was expressed with Fc tag at the C-terminal.
HAVCR2-0760C Recombinant Canine HAVCR2 protein, His-tagged HEK293 Canine His 24-189 a.a.
HAVCR2-0762M Recombinant Mouse HAVCR2 protein, His-tagged HEK293 Mouse His 20-191 a.a.
HAVCR2-0763M Recombinant Mouse HAVCR2 protein, Fc-tagged HEK293 Mouse Fc 20-191 a.a.
HAVCR2-110H Recombinant Human HAVCR2 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Human Fc&His Ser22-Arg200
HAVCR2-111H Recombinant Human HAVCR2 Protein (ECD), His-tagged(C-ter) HEK293 Human His Ser22-Arg200
Havcr2-112M Recombinant Mouse HAVCR2 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Mouse Fc&His Arg20-Arg191
Havcr2-113M Recombinant Mouse HAVCR2 Protein (ECD), His-tagged(C-ter) HEK293 Mouse His Arg20-Arg191
HAVCR2-1246H Active Recombinant Human HAVCR2 protein, hFc&His-tagged HEK293 Human Fc&His Ser22-Arg200
Havcr2-138M Recombinant Mouse Havcr2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
Havcr2-138M-B Recombinant Mouse Havcr2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
HAVCR2-1454H Recombinant Human HAVCR2 Protein (Ser22-Arg200), N-His tagged E.coli Human His Ser22-Arg200
HAVCR2-149H Recombinant Human HAVCR2 Protein, His-tagged E.coli Human His
HAVCR2-2023H Recombinant Human HAVCR2 protein, His-tagged HEK293 Human His Ser22-Arg200
HAVCR2-215H Recombinant Human hepatitis A virus cellular receptor 2 Protein, His&Flag tagged HEK293 Human Flag&His 22-202aa
HAVCR2-2610H Active Recombinant Human HAVCR2 protein, His-tagged HEK293 Human His Ser22-Arg200
HAVCR2-3019H Recombinant Human HAVCR2 protein, His-tagged E.coli Human His 22-202aa
HAVCR2-3166HB Recombinant Human HAVCR2 protein(Met1-Arg200), His-tagged, Amine-Labeled Biotinylated HEK293 Human His 1-200 a.a.
HAVCR2-3488HF Recombinant Full Length Human HAVCR2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 142 amino acids
HAVCR2-3637H Recombinant Human HAVCR2 Protein (Met1-Arg200), C-His tagged Mammalian Cells Human His Met1-Arg200
HAVCR2-367H Active Recombinant Human HAVCR2 protein, mFc-tagged HEK293 Human mFc Ser 22 - Arg 200
HAVCR2-371H Recombinant Human HAVCR2 protein, Fc-tagged HEK293 Human Fc 121
HAVCR2-455H Recombinant Human HAVCR2 Protein, Fc-tagged HEK293 Human Fc 301
HAVCR2-5025H Recombinant Human HAVCR2 protein, hFc-tagged HEK293 Human Fc 20-200aa
HAVCR2-5404H Recombinant Human HAVCR2 Protein (Ser22-Arg200), C-Fc and His tagged Mammalian Cells Human Fc&His Ser22-Arg200
HAVCR2-5405H Recombinant Human HAVCR2 Protein (Ser22-Arg200), C-His tagged Mammalian Cells Human His Ser22-Arg200
HAVCR2-5422H Recombinant Human HAVCR2 protein, His-tagged Yeast Human His 22-202aa
Havcr2-5715M Recombinant Mouse Havcr2 Protein (Leu22-Ala193), C-His tagged Mammalian Cells Mouse His Leu22-Ala193
Havcr2-6822M Recombinant Mouse Havcr2 Protein (Arg20-Arg191), C-Fc tagged Mammalian Cells Mouse Fc Arg20-Arg191
Havcr2-6823M Recombinant Mouse Havcr2 Protein (Arg20-Arg191), C-His tagged Mammalian Cells Mouse His Arg20-Arg191
HAVCR2-731H Recombinant Human HAVCR2 Protein (Ser22-Gly202), C-mFc and 6×His-tagged HEK293 Human His&mFc Ser22-Gly202
HAVCR2-734C Recombinant Cynomolgus monkey HAVCR2 Protein, Fc-tagged HEK293 Cynomolgus Fc 302
HAVCR2-735H Recombinant Human HAVCR2 Protein, Fc-tagged HEK293 Human Fc 301
HAVCR2-737H Recombinant Human HAVCR2 Protein HEK293 Human 301
HAVCR2-738M Recombinant Mouse HAVCR2 Protein HEK293 Mouse 281
HAVCR2-739M Recombinant Mouse HAVCR2 Protein, Fc-tagged HEK293 Mouse Fc 281
HAVCR2-956H Recombinant Human HAVCR2 Protein, His-tagged HEK293 Human His Ser22-Gly202

    Involved Pathway

    HAVCR2 involved in several pathways and played different roles in them. We selected most pathways HAVCR2 participated on our site, such as Cytokine Signaling in Immune system,Immune System,Interleukin-2 signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAVCR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Immune System LTF,BTR06,DUSP3,CLEC2B,CD200,TNFRSF13C,RNF144B,DEFA3,FCN2,NCR3LG1
    Interleukin-2 signaling LGALS9
    Signaling by Interleukins CASPBL,CASPB,IL1RN,SOCS3A,LGALS9
    Cytokine Signaling in Immune system TRIM2,USP18,FRS2A,TRIM62,SPRED1,RASGRP1,LAMTOR2,NUPL2,GBP4,FGF10B

    Protein Function

    HAVCR2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by HAVCR2 itself. We selected most functions HAVCR2 had, and list some proteins which have the same functions with HAVCR2. You can find most of the proteins on our site.

    Function Related Protein

    Interacting Protein

    HAVCR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAVCR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAVCR2.

    Resources

    Research Area

    Cancer Drug Targets
    TIM Family Co-Signaling Molecules
    Leukemia Cancer Stem Cell Markers
    Immune Checkpoints

    References

    • Markwick, LJL; Riva, A; et al. Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients With Acute Alcoholic Hepatitis. GASTROENTEROLOGY 148:590-+(2015).
    • Sabahi, A; Uprichard, SL; et al. Unexpected Structural Features of the Hepatitis C Virus Envelope Protein 2 Ectodomain. JOURNAL OF VIROLOGY 88:10280-10288(2014).

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