Active Recombinant Human HAVCR2 Protein, Fc-Tagged

• Cat.No.: HAVCR2-01H
• Product Overview: Mouse myeloma cell line, NS0-derived Recombinant Human HAVCR2 Protein, Fc-Tagged

Specification

• Species: Human
• Source: NS0
• Tag: Fc
• Description: The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
• Form: Lyophilized
• Bio-activity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Galectin‑9 at 500 ng/mL can bind Recombinant Human TIM-3 Fc Chimera with an apparent Kd <30 nM.
• Molecular Mass: 46.4 kDa (monomer)
• N-terminal Sequence Analysis: Ser22
• Endotoxin: <0.01 EU per 1 μg of the protein by the LAL method.
• Purity: >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 °C as supplied.
  3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Gene Information

• Gene Name: HAVCR2 hepatitis A virus cellular receptor 2 [ Homo sapiens (human) ]
• Official Symbol: HAVCR2
• Synonyms: CD366; FLJ14428; HAVCR2; HAVcr-2; hepatitis A virus cellular receptor 2; kidney injury molecule-3; KIM-3; SPTCL; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; TIM 3; TIM3 T-cell membrane protein 3; TIM3; TIM-3; TIMD3; TIMD-3; TIMD3KIM-3
• Gene ID: 84868
• mRNA Refseq: NM_032782.5
• Protein Refseq: NP_116171.3
• MIM: 606652
• UniProt ID: Q8TDQ0