|Official Full Name||hexosaminidase B (beta polypeptide)|
|Background||Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines.Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes.Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases.Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses.Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II).|
|Synonyms||HEXB; hexosaminidase B (beta polypeptide); beta-hexosaminidase subunit beta; Beta hexosaminidase beta chain; Beta N acetylhexosaminidase; Beta-hexosaminidase subunit beta chain A; Beta-N-acetylhexosaminidase subunit beta; Cervical cancer proto oncogene 7 protein; Cervical cancer proto-oncogene 7 protein; ENC 1AS; HCC 7; HCC-7; HCC7; HEX B; HEXB_HUMAN; Hexosaminidase B; Hexosaminidase subunit B; HexosaminidaseB; N acetyl beta glucosaminidase; N-acetyl-beta-glucosaminidase subunit beta; ENC-1AS|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
hexb involved in several pathways and played different roles in them. We selected most pathways hexb participated on our site, such as Other glycan degradation, Amino sugar and nucleotide sugar metabolism, Glycosaminoglycan degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with hexb were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Other glycan degradation||NEU1; NEU3; NEU3.3; NEU4; MAN2B2; MANBA; NEU3.1; NEU2; MAN2C1; ENGASE|
|Amino sugar and nucleotide sugar metabolism||CMAH; UAP1; UGDH; GMDS; NANP; HEXA; GNPDA1; NANSA; NANS; UAP1L1|
|Glycosaminoglycan degradation||GNS; HYAL3; HYAL1; GNSA; SGSH; HGSNAT; HPSE2; HYAL2; IDS; GUSB|
|Glycosphingolipid biosynthesis - globo series||GBGT1L4; HEXB; GLA; B3GALT5; HEXA; FUT9; A4GALT; ST3GAL2; FUT1; FUT2|
|Glycosphingolipid biosynthesis - ganglio series||ST8SIA1; ST3GAL2; ST6GALNAC6; ST3GAL5; HEXB; ST6GALNAC5; ST8SIA5; ST3GAL1; SLC33A1; GLB1|
|Metabolic pathways||GALNS; HADHAB; NDUFV2; PYCR1B; ALAD; SQLEA; PIP5K1C; XYLB; AKR1A1A; Atp5k|
|Lysosome||CLN5; CTSBB; AP3B2; GALNS; GUSB; NPC2; HGSNAT; PLA2G15; CTPS1B; NPC1|
hexb has several biochemical functions, for example, acetylglucosaminyltransferase activity, beta-N-acetylhexosaminidase activity, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by hexb itself. We selected most functions hexb had, and list some proteins which have the same functions with hexb. You can find most of the proteins on our site.
|acetylglucosaminyltransferase activity||B3GALNT2; XYLT2; POC1BL; OGT; GTDC2; PIGB; MGAT1; GALNTL4; A4GNT; GALNT18A|
|beta-N-acetylhexosaminidase activity||HEXA; Chil3; HEXB; HEXDC|
|protein heterodimerization activity||IKZF1; Pdgfa&Pdgfb; ATF4; Itgam&Itgb2; H2-Q10; HIST1H2AL; NEUROD2; TLR2; CLNS1A; SIM2|
|protein homodimerization activity||TARBP2; VPS25; HNF1B; CITED1; CBX1; MYOM1; BNIP3; VIL1; AIMP1; DLK2|
hexb has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hexb here. Most of them are supplied by our site. Hope this information will be useful for your research of hexb.
CSNK2B; SOD1; Tuba3a; Bach1; Nup214; Tgs1; SMC6; TSNAX; Kif19