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Official Full Name hexosaminidase B (beta polypeptide)
Background Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines.Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes.Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases.Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses.Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II).
Synonyms HEXB; hexosaminidase B (beta polypeptide); beta-hexosaminidase subunit beta; Beta hexosaminidase beta chain; Beta N acetylhexosaminidase; Beta-hexosaminidase subunit beta chain A; Beta-N-acetylhexosaminidase subunit beta; Cervical cancer proto oncogene 7 protein; Cervical cancer proto-oncogene 7 protein; ENC 1AS; HCC 7; HCC-7; HCC7; HEX B; HEXB_HUMAN; Hexosaminidase B; Hexosaminidase subunit B; HexosaminidaseB; N acetyl beta glucosaminidase; N-acetyl-beta-glucosaminidase subunit beta; ENC-1AS
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HEXB-1090H Recombinant Human HEXB Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HEXB-27728TH Recombinant Human HEXB Wheat Germ N/A
    Human HEXB-302H Recombinant Human HEXB, His-tagged Human Cell His
    Human HEXB-4711H Recombinant Human HEXB Protein, GST-tagged Wheat Germ GST
    Human HEXB-644H Recombinant Human HEXB protein, His-tagged E.coli His
    Human HEXB-645H Recombinant Human HEXB protein, His-tagged E.coli His
    Human HEXB-756HCL Recombinant Human HEXB cell lysate Human Cell N/A
    Mouse Hexb-1014M Recombinant Mouse Hexb Protein, His-tagged HEK293 His
    Mouse Hexb-1117M Recombinant Mouse Hexb Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Hexb-646M Recombinant Mouse Hexb protein, His-tagged E.coli His
    Mouse Hexb-647M Recombinant Mouse Hexb protein, His-tagged E.coli His
    Mouse HEXB-7594M Recombinant Mouse HEXB Protein Mammalian Cell His
    Rat HEXB-2834R Recombinant Rat HEXB Protein Mammalian Cell His
    Rat Hexb-648R Recombinant Rat Hexb protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque HEXB-2070R Recombinant Rhesus monkey HEXB Protein, His-tagged Mammalian Cell His

    hexb involved in several pathways and played different roles in them. We selected most pathways hexb participated on our site, such as Other glycan degradation, Amino sugar and nucleotide sugar metabolism, Glycosaminoglycan degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with hexb were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Other glycan degradation NEU1; NEU3; NEU3.3; NEU4; MAN2B2; MANBA; NEU3.1; NEU2; MAN2C1; ENGASE
    Amino sugar and nucleotide sugar metabolism CMAH; UAP1; UGDH; GMDS; NANP; HEXA; GNPDA1; NANSA; NANS; UAP1L1
    Glycosaminoglycan degradation GNS; HYAL3; HYAL1; GNSA; SGSH; HGSNAT; HPSE2; HYAL2; IDS; GUSB
    Glycosphingolipid biosynthesis - globo series GBGT1L4; HEXB; GLA; B3GALT5; HEXA; FUT9; A4GALT; ST3GAL2; FUT1; FUT2
    Glycosphingolipid biosynthesis - ganglio series ST8SIA1; ST3GAL2; ST6GALNAC6; ST3GAL5; HEXB; ST6GALNAC5; ST8SIA5; ST3GAL1; SLC33A1; GLB1
    Metabolic pathways GALNS; HADHAB; NDUFV2; PYCR1B; ALAD; SQLEA; PIP5K1C; XYLB; AKR1A1A; Atp5k

    hexb has several biochemical functions, for example, acetylglucosaminyltransferase activity, beta-N-acetylhexosaminidase activity, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by hexb itself. We selected most functions hexb had, and list some proteins which have the same functions with hexb. You can find most of the proteins on our site.

    Function Related Protein
    acetylglucosaminyltransferase activity B3GALNT2; XYLT2; POC1BL; OGT; GTDC2; PIGB; MGAT1; GALNTL4; A4GNT; GALNT18A
    beta-N-acetylhexosaminidase activity HEXA; Chil3; HEXB; HEXDC
    protein heterodimerization activity IKZF1; Pdgfa&Pdgfb; ATF4; Itgam&Itgb2; H2-Q10; HIST1H2AL; NEUROD2; TLR2; CLNS1A; SIM2
    protein homodimerization activity TARBP2; VPS25; HNF1B; CITED1; CBX1; MYOM1; BNIP3; VIL1; AIMP1; DLK2

    hexb has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hexb here. Most of them are supplied by our site. Hope this information will be useful for your research of hexb.

    CSNK2B; SOD1; Tuba3a; Bach1; Nup214; Tgs1; SMC6; TSNAX; Kif19

    Villamizar-Schiller, IT; Pabon, LA; et al. Neurological and cardiac responses after treatment with miglustat and a ketogenic diet in a patient with Sandhoff disease. EUROPEAN JOURNAL OF MEDICAL GENETICS 58:180-183(2015).
    Walia, JS; Altaleb, N; et al. Long-Term Correction of Sandhoff Disease Following Intravenous Delivery of rAAV9 to Mouse Neonates. MOLECULAR THERAPY 23:414-422(2015).

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