Recombinant Human HEXB Protein, GST-tagged

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Recombinant Human HEXB Protein, GST-tagged

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Cat.No. : HEXB-4711H
Product Overview : Human HEXB full-length ORF ( NP_000512.1, 1 a.a. - 556 a.a.) recombinant protein with GST-tag at N-terminal.
Description : Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 89.5 kDa
AA Sequence : MELCGLGLPRPPMLL ALLLATLLAAMLALL TQVALVVQVAEAARA PSVSAKPGPALWPLP LSVKMTPNLLHLAPE NFYISHSPNSTAGPS CTLLEEAFRRYHGYI FGFYKWHHEPAEFQA KTQVQQLLVSITLQS ECDAFPNISSDESYT LLVKEPVAVLKANRV WGALRGLETFSQLVY QDSYGTFTINESTII DSPRFSHRGILIDTS RHYLPVKIILKTLDA MAFNKFNVLHWHIVD DQSFPYQSITFPELS NKGSYSLSHVYTPND VRMVIEYARLRGIRV LPEFDTPGHTLSWGK GQKDLLTPCYSRQNK LDSFGPINPTLNTTY SFLTTFFKEISEVFP DQFIHLGGDEVEFKC WESNPKIQDFMRQKG FGTDFKKLESFYIQK VLDIIATINKGSIVW QEVFDDKAKLAPGTI VEVWKDSAYPEELSR VTASGFPVILSAPWY LDLISYGQDWRKYYK VEPLDFGGTQKQKQL FIGGEACLWGEYVDA TNLTPRLWPRASAVG ERLWSSKDVRDMDDA YDRLTRHRCRMVERG IAAQPLYAGYCNHEN M
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : HEXB hexosaminidase B (beta polypeptide) [ Homo sapiens ]
Official Symbol : HEXB
Synonyms : HEXB; hexosaminidase B (beta polypeptide); beta-hexosaminidase subunit beta; HCC-7; hexosaminidase subunit B; beta-N-acetylhexosaminidase subunit beta; cervical cancer proto-oncogene 7 protein; N-acetyl-beta-glucosaminidase subunit beta; ENC-1AS;
Gene ID : 3074
mRNA Refseq : NM_000521
Protein Refseq : NP_000512
MIM : 606873
UniProt ID : P07686

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