HFE
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Official Full Name
hemochromatosis
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Overview
Human hemochromatosis protein also known as the HFE protein is a protein which in humans is encoded by the HFE gene. The HFE gene is located on short arm of chromosome 6 at location 6p21.3. Unusually, the official gene symbol (HFE for High Iron Fe) is not an abbreviation of the official name (hemochromatosis) -
Synonyms
hemochromatosis; HFE; HH; HFE1; HLA-H; MVCD7; TFQTL2; hereditary; hemochromatosis protein; high Fe; MHC class I-like protein HFE; hereditary hemochromatosis protein HLA-H;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Mus musculus (Mouse)
- Rattus norvegicus (Rat)
- Rhesus Macaque
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In vitro E. coli expression system
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- MYC
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- HFE Related Articles
HFE involved in several pathways and played different roles in them. We selected most pathways HFE participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HFE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
HFE has several biochemical functions, for example, beta-2-microglobulin binding, co-receptor binding, NOT peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HFE itself. We selected most functions HFE had, and list some proteins which have the same functions with HFE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-2-microglobulin binding | CD1B;HLA-E;H2-Q10;HLA-A;CD1d1;CD1C;CD1E;CD1D;HFE |
| co-receptor binding | TFR2;BMP2;HFE;DKK1;NEO1;BMP4 |
| NOT peptide antigen binding | FCGRT;HFE |
| protein binding | IREB2;PTPN18;RIPPLY1;FBXO5;CDCA4;STX5;E2F1;NGF;ETS2 |
| receptor binding | TYROBP;BLK;NRG2B;HLA-G;DRD1A;EPB49;NCR3;NPFF;LRRC4B |
| transferrin receptor binding | Trf;HFE;TF;SNX1;RGMA;SNX2;HFE2;SNX4;CD81 |
HFE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HFE here. Most of them are supplied by our site. Hope this information will be useful for your research of HFE.
B2M; TFRC; pnp; q7chd9_yerpe; q81lj8_bacan; iolA2; TF; HSPA5
- Q&As
- Reviews
Q&As (6)
Ask a questionThe level of HFE recombinant protein in pregnant women may change due to the needs of fetal growth and development, and regular monitoring is required.
If the level of HFE recombinant protein is abnormal, treatment may include dietary modification, medication, or other specific treatments, depending on the condition and the doctor's recommendation.
Some studies have shown that HFE recombinant protein may be involved in the occurrence and progression of tumors, especially in tumors associated with iron metabolism such as liver cancer and gastric cancer.
The current treatments for HFE recombinant proteins mainly include gene therapy, protein replacement therapy, and drug therapy for iron metabolism.
HFE recombinant proteins are associated with some iron metabolism-related diseases, such as hereditary hemochromatosis (HFE-related) and non-alcoholic fatty liver disease.
Some patients with anemia may have abnormal levels of HFE recombinant protein, but the specific association and treatment need to be evaluated on an individual basis.
Customer Reviews (3)
Write a reviewThe stability is very good and does not denature even at low temperatures.
The biological activity is very strong and can be used in various biological experiments.
The HFE structure is very stable and not prone to mutations.
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