• Official Full Name

    hypermethylated in cancer 1

  • Overview

    This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010]
  • Synonyms

    HIC1; hypermethylated in cancer 1; hic-1; ZBTB29; ZNF901; hypermethylated in cancer 1 protein; zinc finger and BTB domain-containing protein 29;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HIC1-4744H Recombinant Human HIC1 Protein, GST-tagged Wheat Germ GST
Human HIC1-245H Recombinant Human HIC1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HIC1-29312TH Recombinant Human HIC1 Wheat Germ N/A 79 amino acids
Human HIC1-1409H Recombinant Human HIC1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse HIC1-7620M Recombinant Mouse HIC1 Protein Mammalian Cell His
Mouse Hic1-1125M Recombinant Mouse Hic1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HIC1-4160M-B Recombinant Mouse HIC1 Protein Pre-coupled Magnetic Beads HEK293
Mouse HIC1-4160M Recombinant Mouse HIC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HIC1-463Z Recombinant Zebrafish HIC1 Mammalian Cell His
Chicken HIC1-6789C Recombinant Chicken HIC1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HIC1 involved in several pathways and played different roles in them. We selected most pathways HIC1 participated on our site, such as Direct p53 effectors, E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Direct p53 effectorsGADD45A;DUSP1;PRDM1;ZNF385A;CTSD;CSE1L;TADA2B;S100A2;TRIAP1
E2F transcription factor networkDHFR;HIC1;MYBL2;RYBP;CEBPA;HBP1;CES5A;SMARCA2;YY1

HIC1 has several biochemical functions, for example, histone deacetylase binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIC1 itself. We selected most functions HIC1 had, and list some proteins which have the same functions with HIC1. You can find most of the proteins on our site.

Function Related Protein
histone deacetylase bindingMAGEA2B;D7ERTD443E;CEBPA;SKOR2;FOXP3;BRMS1LA;HDAC1;TFAP4;RFXANK
metal ion bindingHEPHL1;ZNF554;AFP;ZNF18;SETDB1B;TRIM55B;PRMT3;PVALB9;ZNF468
protein bindingCDK11B;EXOSC7;CSN3;PBK;EBF1;ZNF232;CST5;NRSN1;C18orf56
sequence-specific DNA bindingDMRT2;ZFP42;NR2F1B;FOXF2;SALL4;ZNF397;NFE2L2B;GCM2;SATB1A
transcription factor activity, sequence-specific DNA bindingZSCAN4D;ZKSCAN14;ONECUT3;SIX3;ZFP11;SOX5;ZNF573;SHOX;ZNF792

HIC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIC1.

Ctbp1; CTBP1; TCF7L2

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