Recombinant Human HIC1

Cat.No. : HIC1-29312TH
Product Overview : Recombinant fragment corresponding to amino acids 627-705 of Human HIC1 with N terminal proprietary tag; Predicted MWt 34.32 kDa.
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Description : This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants.
Protein length : 79 amino acids
Molecular Weight : 34.320kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Ubiquitously expressed with highest levels found in lung, colon, prostate, thymus, testis and ovary. Expression is absent or decreased in many tumor cells.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : PEGVFAVARLTAEQLSLKQQDKAAA AELLAQTTHFLHDPKVALESLYPLA KFTAELGLSPDKAAEVLSQGAHLAA GPDG
Sequence Similarities : Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.Contains 1 BTB (POZ) domain.Contains 5 C2H2-type zinc fingers.
Gene Name : HIC1 hypermethylated in cancer 1 [ Homo sapiens ]
Official Symbol : HIC1
Synonyms : HIC1; hypermethylated in cancer 1; hypermethylated in cancer 1 protein; ZBTB29; ZNF901;
Gene ID : 3090
mRNA Refseq : NM_001098202
Protein Refseq : NP_001091672
MIM : 603825
Uniprot ID : Q14526
Chromosome Location : 17p13.3
Pathway : Direct p53 effectors, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem;
Function : DNA binding; histone deacetylase binding; metal ion binding; protein binding; sequence-specific DNA binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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