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Official Full Name histone cluster 4, H4
Background Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Jul 2008]
Synonyms HIST4H4; histone cluster 4, H4; H4/p; histone H4; histone 4, H4;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HIST4H4-29325TH Recombinant Human HisT4H4, His-tagged Wheat Germ His
    Human HIST4H4-401H Recombinant Human HIST4H4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HIST4H4-4819H Recombinant Human HIST4H4 Protein, GST-tagged Wheat Germ GST
    Human HIST4H4-490H Recombinant Human HIST4H4 protein E.coli N/A
    Human HIST4H4-5510HCL Recombinant Human HIST4H4 293 Cell Lysate HEK293 N/A
    Mouse Hist4h4-372M Recombinant Mouse Hist4h4 Protein, His-tagged E.coli His

    hist4h4 involved in several pathways and played different roles in them. We selected most pathways hist4h4 participated on our site, such as Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3, Alcoholism, Amyloid formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with hist4h4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 HIST4H4; KDM1A; HIST2H3C; HIST3H2BB; KDM4C; NCOA2
    Amyloid formation MFGE8; CEACAM21; LTF; NAT8B; SAA1; CALCA; APCS; CST3; ODAM; HIST3H2BB
    Cell Cycle LEMD3; TERF2; CEP76; CP110; CDC23; ORC1L; ANAPC11; MCM10; FKBP6; ACD
    Cell Cycle Checkpoints CHEK2; CLSPN; FAM175A; HIST3H2BB; HIST4H4; BARD1; UIMC1; MCM10; CHEK1; RAD17
    Cell Cycle, Mitotic CTDNEP1A; KNTC1; TOP2A; TUBGCP4; SMC4; KIF2A; CCP110; ACTR1A; CSNK1D; DCTN3
    Cellular Senescence POT1; HIST1H1B; Txn1; CBX6; HMGA1B; TERF1; RAD50; SUZ12A; CDK4; CDKN2B
    Cellular responses to stress H1F0; WDR45L; ATG9B; HIRA; HMGA1; AGO1; ERF; EGLN3; EP400; CHMP4C

    hist4h4 has several biochemical functions, for example, DNA binding, histone binding, histone demethylase activity (H4-K20 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by hist4h4 itself. We selected most functions hist4h4 had, and list some proteins which have the same functions with hist4h4. You can find most of the proteins on our site.

    Function Related Protein
    histone binding HIST1H4B; HIST1H3D; DEK; ATRX; SMARCA2; PIH1D1; HIST1H47; BAZ2A; HIST1H4F; TONSL
    histone demethylase activity (H4-K20 specific) HIST2H4A; HIST1H4K; HIST1H4E; HIST1H4L; HIST1H4C; HIST1H4J; HIST1H4F; HIST1H4A; JHDM1D; HIST1H4H
    poly(A) RNA binding RBPMS; PRAC; PPP1R10; PRMT1; RALYL; GDI2; DHX32; RPS9; NOP56; RPL7
    protein binding HIST1H4K; OSBP; TERF2; CEP55; MEPE; ALX1; DKC1; Artn; PPP5C; TSTD2
    protein domain specific binding THRA; GNAI3; SHROOM2; YWHAE1; ARR3; ERCC1; PPARA; CEP68; CHMP1A; CNTLN
    protein heterodimerization activity UBA3; WHRN; GRIN2A; SNX5; CUL3; CA; CHRNA3; JAM3; CHRNB2; SEPHS1

    hist4h4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hist4h4 here. Most of them are supplied by our site. Hope this information will be useful for your research of hist4h4.

    KDM4A; TP53BP1; SETD8

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