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Official Full Name major histocompatibility complex, class I, B
Background HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
Synonyms HLA-B; major histocompatibility complex, class I, B; ankylosing spondylitis , AS; lymphocyte antigen; MHC class I antigen SHCHA; MHC Class I HLA heavy chain; MHC class I antigen GN00104; leukocyte antigen class I-B; MHC HLA-B cell surface glycoprotein; MH
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-B-1894H Recombinant Human HLA-B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HLA-B-245H Recombinant Human HLA-B Protein, His-tagged E.coli His
    Human HLA-B-354H Recombinant Human HLA-B Protein, Flag-tagged HEK293T Flag
    Human HLA-B-392H Recombinant Human HLA-B protein, His/T7-tagged E.coli His/T7
    Human HLA-B-4833H Recombinant Human HLA-B Protein, GST-tagged Wheat Germ GST
    Human HLA-B-5495HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
    Human HLA-B-8392H Recombinant Human HLA-B protein, His-tagged HEK293 His

    hla-b involved in several pathways and played different roles in them. We selected most pathways hla-b participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with hla-b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome ATP6V0D2; PIK3C3; DYNC1I1; TUBB; TUBA3E; TUBA4L; BLA; SEC22BB; FCGR3A; Itgam&Itgb2
    Cell adhesion molecules (CAMs) PVRL1; ITGB7; CADM1B; LRRC4B; CD274; CLDNG; CLDN15; CLDNK; NRCAM; CNTNAP2A
    Antigen processing and presentation CTSL1; HLA-A; RFX5; TAPBP; HSPA1L; TAP2; KIR2DS5; TNF; PDIA3; KLRC1
    Natural killer cell mediated cytotoxicity IFNA8; IFNA7; IFNA10; IFNA2; Raet1c; SH3BP2; FAS; LAT; PIK3R2; RAET1G
    Type I diabetes mellitus HLA-DOB; IL1A; HLA-C; CD28; HLA-DRB4; HLA-DQA1; HLA-E; HLA-DRB5; HLA-F; FASLG
    HTLV-I infection FZD10; WNT10B; CCND3; FOSL1; WNT9B; NRP1; VDAC3; ETS1; MRAS; MSX1
    Herpes simplex infection IKBKB; HLA-DRB4; CASP3A; PER2; CLOCK; IL1B; IFNPHI1; FASLG; TRP53; TBPL1
    Epstein-Barr virus infection PSMD8; HLA-DQB1; PLCG2; RB1; RBPJ; YWHAE; PSMD13; GTF2E1; IRF3; NFKBIA
    Viral carcinogenesis TP53; HIST1H2BG; HIST1H4L; EGR3; HIST1H2BH; HIST3H2BB-PS; HIST1H2BN; HIST1H2BO; SCRIB; ACTN3
    ne thyroid disease HLA-DOA; HLA-DMA; CD40; IFNA16; IL5; TPO; H2-AB1; IFNA21; CD40LG; TG
    Allograft rejection HLA-DOB; HLA-F; CD80; HLA-DQA2; CD86; HLA-DQA1; FASLG; H2-Q10; GZMB; HLA-DMA
    Graft-versus-host disease Il2; HLA-DOB; H2-Q10; CD86; KLRD1; HLA-DQB1; HLA-F; HLA-E; HLA-DQA1; IL6
    Viral myocarditis PRF1; CXADR; FYN; EIF4G2; HLA-DRB3; RAC3; CCND1; HLA-DRB1; HLA-DRB5; HLA-DQB1

    hla-b has several biochemical functions, for example, TAP binding, NOT TAP binding, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hla-b itself. We selected most functions hla-b had, and list some proteins which have the same functions with hla-b. You can find most of the proteins on our site.

    Function Related Protein
    TAP binding HLA-A; HLA-C; HLA-B; H2-Q10
    NOT TAP binding HLA-B
    chaperone binding DNAJA3B; BAX; SLC25A17; TSC1; CXorf41; DNAJB2; CALR; DLST; BAK1; TIMM10
    peptide antigen binding TUBB3; HLA-DRA; H2-AA; HLA-G; HLA-DPA1; HLA-DRB5; MHC1ZDA; HLA-B; AZGP1; HLA-DQB1
    receptor binding ADCYAP1; CRAT; SLC39A1; FGF1B; MYO1C; INSL3; WNT7A; NPFF; GBA; ARPP19

    hla-b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hla-b here. Most of them are supplied by our site. Hope this information will be useful for your research of hla-b.

    HLA-C; STAT1; ltp_ebvg; ARHGEF4; GABARAP

    Bossini-Castillo, L; de Kovel, C; et al. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).
    Bet, A; Maze, EA; et al. The HIV-1 Antisense Protein (ASP) induces CD8 T cell responses during chronic infection. RETROVIROLOGY 12:-(2015).

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