Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

HLA-B

  • Official Full Name

    major histocompatibility complex, class I, B

  • Overview

    HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
  • Synonyms

    HLA-B; major histocompatibility complex, class I, B; ankylosing spondylitis , AS; lymphocyte antigen; MHC class I antigen SHCHA; MHC Class I HLA heavy chain; MHC class I antigen GN00104; leukocyte antigen class I-B; MHC HLA-B cell surface glycoprotein; MH;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLA-B-392H Recombinant Human HLA-B protein, His/T7-tagged E.coli His/T7
Human HLA-B-4833H Recombinant Human HLA-B Protein, GST-tagged Wheat Germ GST
Human HLA-B-5495HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
Human HLA-B-245H Recombinant Human HLA-B Protein, His-tagged E.coli His Ser26~Val309
Human HLA-B-242HFL Recombinant Full Length Human HLA-B Protein, C-Flag-tagged Mammalian cells Flag
Human HLA-B-354H Recombinant Human HLA-B Protein, Flag-tagged HEK293T Flag
Human HLA-B-1894H Recombinant Human HLA-B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HLA-B-8392H Recombinant Human HLA-B protein, His-tagged HEK293 His
Human HLA-B-1074H Recombinant Human HLA-B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HLA-B-5293H Recombinant Human HLA-B protein, His-tagged E.coli His 25-308aa
Human HLA-B-1074H-B Recombinant Human HLA-B Protein Pre-coupled Magnetic Beads HEK293
Human HLA-B-3559HF Recombinant Full Length Human HLA-B Protein, GST-tagged In Vitro Cell Free System GST 362 amino acids
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLA-B Related Articles
  • HLA-B Related Gene Family

HLA-B involved in several pathways and played different roles in them. We selected most pathways HLA-B participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisARFGAP3;WWP1;RAB35B;ARPC5A;LDLRA;DNM2A;SH3GL3;ARFGEF1;GIT1
PhagosomeTUBB2B;ATP6V0A1B;ITGA5;BLB2;ATP6V1E1;H2-AA;TFRC;BLA;MHC1UEA
Cell adhesion molecules (CAMs)MHC2DCB;Ntng2;CLDN23;BLB2;NCAM1;NRCAMA;H2-Q10;CLDN15LB;HLA-F
Antigen processing and presentationCtsl;IFNG;CD4;NFYA;CALR;KIR2DS5;LGMN;KLRD1;HLA-DRB4
Natural killer cell mediated cytotoxicityPRF1;HRAS;KLRC2;Raet1c;KLRK1;FAS;CD247;Casp3;PIK3CB
Type I diabetes mellitusHLA-DRB4;PTPRN2;H2-Q10;ICA1;HLA-DQA1;HLA-DQB1;INS2;HLA-E;TNF
HTLV-I infectionFZD10;GM-CSF;EP300;HLA-B;POLB;PIK3R3;HLA-DOB;HRAS;WNT9B
Herpes simplex infectionIFNA1;EIF2AK4;HLA-B;SP100;USP7;PER1;SKP2;POLR2A;IL6
Epstein-Barr virus infectionPOLR2F;HLA-F;POLR3B;TYK2;PSMC2;HSPB2;POLR1D;POLR2J;HSPB1
Viral carcinogenesisACTN3;LYN;HIST1H4M;SRC;TRP53;PIK3R3;CCND2;PIK3R5;HDAC9
AutoiHLA-DRB3;HLA-DPA1;IFNA4;Il2;H2-AA;IL5;HLA-DMA;HLA-A;TSHR
ne thyroid diseaseHLA-DRA;HLA-F;GZMB;HLA-B;IFNA5;PRF1;CD80;Ifna15;IFNA10
Allograft rejectionHLA-A;HLA-DRB1;IL12B;HLA-E;HLA-DRB4;CD86;HLA-DQA2;IFNG;Il2
Graft-versus-host diseaseHLA-DPB1;HLA-B;CD28;GZMB;TNF;IL1B;HLA-DRB1;KLRC1;HLA-DQB1
Viral myocarditisHLA-DPB1;H2-AA;HLA-DQA1;CD28;ICAM1;HLA-DRB3;HLA-DQB1;ITGAL;EIF4G3

HLA-B has several biochemical functions, for example, TAP binding, NOT TAP binding, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-B itself. We selected most functions HLA-B had, and list some proteins which have the same functions with HLA-B. You can find most of the proteins on our site.

Function Related Protein
TAP bindingHLA-A;HLA-B;HLA-C;H2-Q10
NOT TAP binding
chaperone bindingGET4;TIMM10;GNB5;PACRG;BAG4;CDC37;HSPA5;CLU;Alb
peptide antigen bindingHLA-DRA;MHC1UEA;HLA-B;H2-Q10;MHC1ZE;CLEC4M;HLA-DRB4;AZGP1;HLA-DPA1
receptor bindingAPLN;ACOT2;LYN;NPFF;LRRC4B;IL28A;CD160;AGXT;RARA

HLA-B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-B here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-B.

HLA-C; STAT1; ltp_ebvg; ARHGEF4; GABARAP

Bossini-Castillo, L; de Kovel, C; et al. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).
Bet, A; Maze, EA; et al. The HIV-1 Antisense Protein (ASP) induces CD8 T cell responses during chronic infection. RETROVIROLOGY 12:-(2015).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All HLA-B Products

Required fields are marked with *

My Review for All HLA-B Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends