HLA-B Protein


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Official Full Name major histocompatibility complex, class I, B
Background HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
Synonyms HLA-B; major histocompatibility complex, class I, B; ankylosing spondylitis , AS; lymphocyte antigen; MHC class I antigen SHCHA; MHC Class I HLA heavy chain; MHC class I antigen GN00104; leukocyte antigen class I-B; MHC HLA-B cell surface glycoprotein; MH
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-B-392H Recombinant Human HLA-B protein, His/T7-tagged E.coli His/T7
    Human HLA-B-5293H Recombinant Human HLA-B protein, His-tagged E.coli His
    Human HLA-B-1894H Recombinant Human HLA-B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HLA-B-245H Recombinant Human HLA-B Protein, His-tagged E.coli His
    Human HLA-B-354H Recombinant Human HLA-B Protein, Flag-tagged HEK293T Flag
    Human HLA-B-4833H Recombinant Human HLA-B Protein, GST-tagged Wheat Germ GST
    Human HLA-B-5495HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
    Human HLA-B-8392H Recombinant Human HLA-B protein, His-tagged HEK293 His

    HLA-B involved in several pathways and played different roles in them. We selected most pathways HLA-B participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis WASH; H2-Q10; EHD1B; CXCR4A; GRK7A; SH3GL3A; ADRB3; GBF1; SNX1A; WASH1
    Phagosome CD209A; CLEC7A; ATP6V0A2; CORO1A; TUBB2A; MHC2DCB; ATP6V0B; STX12; MPO; TAP2
    Cell adhesion molecules (CAMs) ITGAL; CLDN23; NEO1; CD8B; ITGB8; CLDNE; NRCAM; CD6; MPZL1; CLDN10A
    Antigen processing and presentation CALR; HLA-C; LGMN; KIR2DS3; HLA-DRB5; HLA-DRB1; TAP2; B2M; RFXANK; HSPA8
    Natural killer cell mediated cytotoxicity BID; KIR3DL2; NCR3; SYK; PIK3CD; NRAS; H60a; FCGR3A; HLA-A; SOS1
    Type I diabetes mellitus FAS; IL12B; H2-AB1; HLA-F; Il2; PRF1; INS; HLA-DRB1; CD86; LTA
    Herpes simplex infection BMA1; TAF6L; TNF; BF2; MAPK8A; TAF10; IKBKB; MHC1UXA2; CYCSB; BLA
    Epstein-Barr virus infection TAB1; PSMD7; TRP53; PIK3CA; POLR3B; MDM2; IRF3; PIK3R2; POLR3F; GTF2E1
    Viral carcinogenesis HIST2H4; SP100; GTF2E2; H2-Q10; PIK3R5; HIST1H2BF; GTF2B; GTF2A1; CCNA1; IL6ST
    Autoi HLA-A; IFNA14; HLA-E; IFNA13; IFNA1; GZMB; IFNA4; CD28; IFNA12; IFNA21
    ne thyroid disease HLA-DQA1; CD40LG; HLA-DRA; HLA-DQA2; TSHR; CD86; FASLG; IL5; HLA-C; HLA-F
    Allograft rejection CD80; HLA-DRB1; GZMB; HLA-DMB; FAS; HLA-DQB1; H2-Q10; CD40; HLA-DRA; IL5
    Graft-versus-host disease HLA-DQB1; HLA-DRB1; KLRD1; HLA-DOA; Fasl; H2-AA; PRF1; TNF; HLA-DQA2; CD80
    Viral myocarditis Casp3; BID; HLA-B; HLA-E; PRF1; HLA-DRA; CYCS; HLA-DOA; HLA-A; ITGAL

    HLA-B has several biochemical functions, for example, TAP binding, NOT TAP binding, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-B itself. We selected most functions HLA-B had, and list some proteins which have the same functions with HLA-B. You can find most of the proteins on our site.

    Function Related Protein
    TAP binding HLA-A; HLA-C; HLA-B; H2-Q10
    NOT TAP binding HLA-B
    chaperone binding PACRG; HSCB; INS1; BAG4; SERPINA7; ATP1A1; PARK2; DNAJA2L; TIMM10; CLU
    peptide antigen binding MHC1ZHA; MHC1UXA2; HLA-B; HLA-DRB1; MHC1ZKA; HLA-A; CD209; TAPBP; HLA-DPB1; MHC1ZE
    receptor binding ADM; WNT2BA; CD58; CSNK2B; CRTAM; LRRC4B; SERPINE1; HRG; FGF6A; PANX1

    HLA-B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-B here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-B.

    HLA-C; STAT1; ltp_ebvg; ARHGEF4; GABARAP

    Bossini-Castillo, L; de Kovel, C; et al. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).
    Bet, A; Maze, EA; et al. The HIV-1 Antisense Protein (ASP) induces CD8 T cell responses during chronic infection. RETROVIROLOGY 12:-(2015).

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