Recombinant Human HLA-B protein, His-tagged

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Recombinant Human HLA-B protein, His-tagged

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Cat.No. : HLA-B-8392H
Product Overview : Recombinant Human HLA-B protein(NP_005505.2), fused to His-tag, was expressed in HEK293.
Description : HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
Source : HEK293
Species : Human
Tag : His
Form : Supplied as a 0.2 μm filtered solution in PBS, pH 7.4.
Molecular Mass : The protein has a calculated MW of 33.6 kDa.
AA Sequence : HHHHHHGSHS MRYFYTSVSR PGRGEPRFIS VGYVDDTQFV RFDSDAASPR EEPRAPWIEQ EGPEYWDRNT QIYKAQAQTD RESLRNLRGY YNQSEAGSHT LQSMYGCDVG PDGRLLRGHD QYAYDGKDYI ALNEDLRSWT AADTAAQITQ RKWEAAREAE QRRAYLEGEC VEWLRRYLEN GKDKLERADP PKTHVTHHPI SDHEATLRCW ALGFYPAEIT LTWQRDGEDQ TQDTELVETR PAGDRTFQKW AAVVVPSGEE QRYTCHVQHE GLPKPLTLRW EPSSQSTVPI
Purity : >75%, by SDS-PAGE
Storage : Store it under sterile conditions at -20 to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Concentration : 0.5 mg/ml
SDS-PAGE of HLA-B-8392H :

Gene Name : HLA-B major histocompatibility complex, class I, B [ Homo sapiens (human) ]
Official Symbol : HLA-B
Synonyms : AS; HLAB; B-4901
Gene ID : 3106
mRNA Refseq : NM_005514.8
Protein Refseq : NP_005505.2
MIM : 142830
UniProt ID : P01889
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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