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Official Full Name major histocompatibility complex, class II, DM beta
Background HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Synonyms HLA-DMB; major histocompatibility complex, class II, DM beta; HLA class II histocompatibility antigen, DM beta chain; D6S221E; RING7; Class II histocompatibility antigen M beta chain; DMB; HLA class II histocompatibility antigen DM beta chain; Major histocompatibility complex class II DM beta; MHC class II antigen DMB; MHC class II antigen HLA DM beta chain; MHC class II HLA DMB; RING 7; OTTHUMP00000029257; OTTHUMP00000178732; MHC class II HLA-DMB; really interesting new gene 7 protein; MHC class II antigen HLA-DM beta chain; class II histocompatibility antigen, M
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Wheat Germ
    • Tag :
    • GST
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DMB-13813H Recombinant Human HLA-DMB, GST-tagged E.coli GST
    Human HLA-DMB-324H Recombinant Human HLA-DMB Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HLA-DMB-4837H Recombinant Human HLA-DMB Protein, GST-tagged Wheat Germ GST
    Human HLA-DMB-5500HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
    Human HLA-DMB-6533H Recombinant Human HLA-DMB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK

    hla-dmb involved in several pathways and played different roles in them. We selected most pathways hla-dmb participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with hla-dmb were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome MRC2; CORO1A; TLR2; FCGR3B; HLA-DPA1; ATP6V1B1; TLR4BB; TLR2-1; Itgam&Itgb2; ATP6V0D1
    Cell adhesion molecules (CAMs) ITGA8; NLGN4A; CLDNH; OCLNB; Icosl; CDH2; CNTNAP2A; CADM1; H2-AB1; NLGN3A
    Antigen processing and presentation KLRC2; IFI30; KIR3DL2; CD8B; RFXANK; KIR2DL3; KLRD1; HLA-DRB4; NFYA; CANX
    Intestinal i Il2; CCL27B; CXCR4B; ICOSLG; TNFRSF13B; MHC2A; HLA-DRB4; HLA-DQB1; ITGB7; IL15RA
    ne network for IgA production CXCR4A; CXCR4; HLA-DOA; IL4; TNFSF13; BMA1; HLA-DMB; CD40; IL15RA; Icosl
    Type I diabetes mellitus PTPRN2; ICA1; GZMB; HLA-DRB3; H2-AA; INS; CD28; HLA-G; HLA-DMB; HLA-DRB4
    Leishmaniasis FCGR1; HLA-DRB5; PTGS2; TLR2; PRKCB; FCGR2A; IL4; FOS; STAT1; HLA-DPB1
    Toxoplasmosis LAMA2; TGFB3; IL10RA; MAPK3; IFNGR1; IFNGR2; PIK3R1; HLA-DMB; BCL2; IRAK4
    Staphylococcus aureus infection CFI; FCGR2B; HLA-DRA; C1QA; FCGR1A; DSG1C; FCAR; CFB; C5AR1; Hc
    Tuberculosis RIPK2; HLA-DQA2; IRAK4; FCER1G; LBP; MAPK10; IFNGR1; LAMP1; KSR1; IFNA5
    Influenza A SLC25A6; HLA-DQA1; STAT2; Ifna15; CXCL8; IFIH1; IL18; OAS1B; LOC100033925; Ifna11
    Herpes simplex infection TRAF5; IFNG; MYD88; CYCSB; IFNA10; HCFC1A; SFRS3B; PER1A; TAF10; EIF2AK3
    Asthma HLA-DOB; HLA-DPA1; HLA-DRA; EPX; IL3; FCER1G; CCL11; H2-AB1; HLA-DPB1; IL13
    Autoi TG; IFNA13; IL4; IFNA21; IFNA8; GZMB; IFNA6; IFNA14; CD86; H2-Q10
    ne thyroid disease CD28; HLA-A; HLA-B; IFNA7; CD40LG; CD40; FAS; Ifna15; TSHB; CD80
    Inflammatory bowel disease (IBD) IL12RB1; Il23a; TLR2; TLR5; HLA-DRB3; IL23; HLA-DRB1; IFNG; IL2RG; GATA3
    Systemic lupus erythematosus IFNG; C4A; HLA-DQA1; HIST1H2AH; HIST1H2BQ; C6; C8A; TRIM21; HIST1H2BG; HIST1H4I
    Rheumatoid arthritis IL-8; CCL20; CD28; H2-AA; Ctsl; HLA-DQA2; HLA-DRB3; HLA-DOB; ATP6V1B2; TLR2
    Allograft rejection TNF; HLA-B; CD86; HLA-G; HLA-DRB4; IL12B; HLA-DMB; HLA-DRB5; Il2; FASLG
    Graft-versus-host disease CD28; HLA-DRB4; KLRD1; FAS; PRF1; KLRC1; FASLG; CD86; KIR3DL2; CD80
    Viral myocarditis SGCB; HLA-DRB4; HLA-B; CCND1; RAC1; FYN; HLA-G; HLA-DRB3; CYCS; ITGB2

    hla-dmb has several biochemical functions, for example, MHC class II protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hla-dmb itself. We selected most functions hla-dmb had, and list some proteins which have the same functions with hla-dmb. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II protein complex binding HLA-DMB; HLA-DRA; HSP90AA1; ATP1B1; MS4A1; CD81; PKM2; HSP90AB1; HLA-DOB; HLA-DMA

    hla-dmb has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hla-dmb here. Most of them are supplied by our site. Hope this information will be useful for your research of hla-dmb.


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