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HLA-DMB

Official Full Name

major histocompatibility complex, class II, DM beta
Overview

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Synonyms

HLA-DMB; major histocompatibility complex, class II, DM beta; HLA class II histocompatibility antigen, DM beta chain; D6S221E; RING7; Class II histocompatibility antigen M beta chain; DMB; HLA class II histocompatibility antigen DM beta chain; Major histocompatibility complex class II DM beta; MHC class II antigen DMB; MHC class II antigen HLA DM beta chain; MHC class II HLA DMB; RING 7; OTTHUMP00000029257; OTTHUMP00000178732; MHC class II HLA-DMB; really interesting new gene 7 protein; MHC class II antigen HLA-DM beta chain; class II histocompatibility antigen, M;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human

Source

E.coli
HEK293
HEK293T
Wheat Germ

Tag

GST
His
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HLA-DMB-4837H	Recombinant Human HLA-DMB Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HLA-DMB-13813H	Recombinant Human HLA-DMB, GST-tagged	E.coli	GST	1-263a.a.	$319 / 25ug
Human	HLA-DMB-324H	Recombinant Human HLA-DMB Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	HLA-DMB-5500HCL	Recombinant Human HLA 293 Cell Lysate	HEK293	N/A		Inquiry
Human	HLA-DMB-3989H	Recombinant Human HLA-DMB protein, His-tagged	E.coli	His	19-218aa	Inquiry
Human	HLA-DMB-6533H	Recombinant Human HLA-DMB Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein

HLA-DMB involved in several pathways and played different roles in them. We selected most pathways HLA-DMB participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DMB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phagosome	ITGA5;TLR2-2;ATP6V1E1B;ITGB5;ITGAM;TUBA8L;RAB5AB;SEC61AL2;LAMP2
Cell adhesion molecules (CAMs)	HLA-DQA1;HLA-DRB4;BLB2;NLGN2;CLDND;L1CAM;HLA-DRB1;NRXN1A;SELP
Antigen processing and presentation	HLA-B;NFYB;HLA-DPA1;HSP90AA1;HSPA2;CTSS;TAP2;HSPA8;CD4
Intestinal i	AICDA;HLA-DMB;CCR9A;Il2;HLA-DRB1;ICOS;CD86;HLA-DMA;IL5
ne network for IgA production	CD40;BLB1;CXCL12;AICDA;IL6;HLA-DRA;Il2;HLA-DRB4;HLA-DRB3
Type I diabetes mellitus	Il2;INS;CPE;LTA;H2-Q10;HLA-G;HLA-DMA;INS2;HLA-F
Leishmaniasis	HLA-DRB4;HLA-DMB;HLA-DPB1;HLA-DRB3;NFKB1;FCGR3;CYBA;IL12A;HLA-DRB1
Toxoplasmosis	MYD88;HLA-DRB5;GNAI1;GNAO1;MAPK8;IL12B;MAPK10;LAMB2;HLA-DOA
Staphylococcus aureus infection	HLA-DRB1;CFB;MBL2;SELPLG;HLA-DMB;C2;HLA-DRB4;Hc;C5AR1
Tuberculosis	Il23a;LAMP2;MAPK8;AKT1;IFNA14;PPP3R2;IFNA16;CAMP;IFNA6
Influenza A	LOC780933;RAF1;KPNA2;DNAJC3;NFKB1;OAS1;Fasl;IFNG;MX1
HTLV-I infection	DVL3;CANX;HLA-B;HLA-A;HLA-DRB4;ATF1;PIK3R1;TSPO;PPP3CB
Herpes simplex infection	TRAF6;RNASEL;GTF2I;TAF13;IRF7;SRSF5;SKP2;LTA;HNRPK
Asthma	CCL11;IL3;IL5;TNF;HLA-DMB;HLA-DRB4;CD40;IL13;HLA-DRB5
Autoi	HLA-DPA1;HLA-DPB1;HLA-DRB5;IL5;IFNA13;Fasl;GZMB;IFNA8;IFNA2
ne thyroid disease	IFNA13;CD80;CD28;IFNA12;HLA-DRA;HLA-DRB5;Ifna11;IFNA14;HLA-DQB1
Inflammatory bowel disease (IBD)	HLA-DRA;IL13;H2-AA;H2-AB1;HLA-DQA1;Il2;HLA-DQA2;IL21R;TGFB3
Systemic lupus erythematosus	HIST1H2BH;H2AFJ;HLA-DQA1;HIST1H4L;HIST1H3F;C3;FCGR1;HLA-DMB;HIST1H2AO
Rheumatoid arthritis	TLR2;ICAM1;TEK;TNFRSF11A;TGFB3;ATP6V0E;TNFSF11;CTLA4;HLA-DRB5
Allograft rejection	HLA-DOA;HLA-DRB1;HLA-DOB;IL4;CD40;HLA-G;HLA-DPA1;IFNG;Fasl
Graft-versus-host disease	HLA-DMB;KIR2DL1;GZMB;FASLG;H2-AA;HLA-B;HLA-DPB1;KLRC1;IL1B
Viral myocarditis	HLA-DOB;HLA-DRB3;H2-AB1;EIF4G3;SGCA;HLA-B;ITGAL;HLA-DQA2;HLA-DRB1

HLA-DMB has several biochemical functions, for example, MHC class II protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DMB itself. We selected most functions HLA-DMB had, and list some proteins which have the same functions with HLA-DMB. You can find most of the proteins on our site.

Function	Related Protein
MHC class II protein complex binding	YWHAE;ATP1B1;MS4A1;CD81;ANXA11;PKM;HSPA8;HSP90AA1;CD74

HLA-DMB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DMB here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DMB.

HLA-DMA; HLA-DRB1; TEAD1; MDM2