hla-dpa1

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hla-dpa1

Official Full Name major histocompatibility complex, class II, DP alpha 1
Background HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons.
Synonyms T1; HLADP; HLASB; HLA-DP1A; HLA-DPA1; HLA class II histocompatibility antigen, DP alpha 1 chain; DP(W3); DP(W4); MHC class II DPA; HLA-SB alpha chain; OTTHUMP00000029066; MHC class II antigen; MHC class II DP3-alpha; Primed lymphocyte test-4; MHC class IIPA1 antigen; HLA class II histocompatibility antigen, DP alpha chain
    • Species :
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DPA1-13816H Recombinant Human HLA-DPA1, GST-tagged E.coli GST
    Human HLA-DPA1-4840H Recombinant Human HLA-DPA1 Protein, GST-tagged Wheat Germ GST
    Human HLA-DPA1-5506HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
    Zebrafish HLA-DPA1-5442Z Recombinant Zebrafish HLA-DPA1 Mammalian Cell His

    hla-dpa1 involved in several pathways and played different roles in them. We selected most pathways hla-dpa1 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with hla-dpa1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome TLR2-1; LAMP1; VAMP3; COLEC12; TUBB2; HLA-DRB1; H2-AB1; ATP6V1BA; ATP6V1G1; CLEC7A
    Cell adhesion molecules (CAMs) CLDN11A; ALCAM; PDCD1; F11R; OCLN; BF2; CD4; CLDN11; NRXN1; TIGIT
    Antigen processing and presentation KIR2DL3; HSPA1L; CANX; HLA-E; KLRC2; CD8B1; CTSS; HLA-DRB5; HSP90AA1; HSPA1B
    Intestinal i HLA-DQA1; CCR9A; HLA-DRB3; CD28; MHC2DAB; CXCL12A; H2-AB1; ICOS; CXCL12B; H2-AA
    ne network for IgA production CD40; HLA-DOB; BLA; MHC2A; CCL25B; TNFRSF17; MHC2DCB; ITGB7; IL5; H2-AA
    Type I diabetes mellitus HLA-DOA; LTA; IL12A; HLA-DRA; GAD1; FASLG; HLA-DPA1; HLA-DQB1; HLA-B; HSPD1
    Leishmaniasis PTPN6; FOS; TAB2; STAT1; ELK1; CR1; HLA-DRA; TLR4; HLA-DMB; MAPK13
    Toxoplasmosis LY96; HLA-DRB1; MAPK9; CYCS; Casp3; MAP2K6; NOS2; IFNG; IL12B; HLA-DPB1
    Staphylococcus aureus infection GM5077; CFH; MASP1; C2; cgr2b; MBL1; PLG; C1RA; DSG1C; FCGR1A
    Tuberculosis TLR1; IFNA6; BAX; Ifna15; CAP18; IFNA4; SPHK1; PPP3CA; MAPK12; IL12B
    Influenza A NLRX1; HLA-DRB4; BMA1; TNFRSF1A; CYCS; MAPK9; NLRP3; PIK3R5; EIF2AK1; BLA
    HTLV-I infection EGR1; HLA-DRB3; RELB; POLD2; VCAM1; PDGFA; TNF; HLA-DPB1; CD40; HLA-B
    Herpes simplex infection IFNA13; PPP1CA; CSNK2A2A; PER1B; MED8; ARNTL1A; GTF2I; HLA-DRB1; SRSF9; HLA-B
    Epstein-Barr virus infection PIK3CG; PSMC3; YWHAH; TRADD; YWHAG; POLR3GL; MAP3K14; NUP214; PIK3CA; MAP2K7
    Asthma CD40; PRG2; HLA-DRA; IL3; HLA-DOA; HLA-DMA; IL4; MS4A2; HLA-DRB4; HLA-DQA1
    Autoi HLA-B; TSHR; IFNA6; HLA-DQB1; HLA-DQA2; IFNA4; IFNA5; HLA-DMA; H2-Q10; IFNA13
    ne thyroid disease IFNA7; CD80; IFNA2; HLA-DQB1; IFNA5; HLA-F; HLA-DPA1; HLA-DOA; HLA-A; TSHR
    Inflammatory bowel disease (IBD) IL17F; HLA-DPB1; TGFB3; Il4ra; IL4; IL6; HLA-DPA1; IL5; TGFB1; HLA-DMB
    Systemic lupus erythematosus CD80; HIST3H2A; FCGR4; C5; GRIN2A; ELANE; FCGR1A; HIST1H3I; HLA-DOA; C3
    Rheumatoid arthritis CD86; IFNG; ATP6V0A2; CCL3L1; HLA-DRB3; TNF; FOS; ATP6V0E; CCL3; ATP6V1B2
    Allograft rejection HLA-DRA; HLA-DRB4; CD28; IL4; FAS; HLA-C; HLA-DRB3; HLA-DQA1; HLA-DRB1; GZMB
    Graft-versus-host disease H2-Q10; HLA-DMB; KLRD1; HLA-DRB5; H2-AB1; KIR3DL2; KLRC1; GZMB; KIR2DL3; KIR3DL1
    Viral myocarditis SGCD; HLA-DOB; HLA-DMB; ABL1; H2-Q10; ACTB; EIF4G3; HLA-DMA; H2-AB1; CASP9

    hla-dpa1 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hla-dpa1 itself. We selected most functions hla-dpa1 had, and list some proteins which have the same functions with hla-dpa1. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II receptor activity HLA-DQB2; HLA-DRA; HLA-DPA1; HLA-DOB; HLA-DRB3; KRT17; HLA-DOA; HLA-DQA1; HLA-DQB1; HLA-DQA2
    peptide antigen binding TAP1; CD209; MHC1ZDA; HLA-DRB4; MHC1UEA; MHC1UIA; TUBB3; TAPBP; HLA-DRB3; DHCR24

    hla-dpa1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hla-dpa1 here. Most of them are supplied by our site. Hope this information will be useful for your research of hla-dpa1.

    CD74; prfC; q7ard3_yerpe; iucD; q7chc4_yerpe

    Gan, SJ; Ye, B; et al. Immune- and Ribosome-Related Genes were Associated with Systemic Vasculitis. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:96-101(2015).
    Ollila, HM; Ravel, JM; et al. HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy. AMERICAN JOURNAL OF HUMAN GENETICS 96:136-146(2015).

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