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HLA-DPA1

Official Full Name

major histocompatibility complex, class II, DP alpha 1
Overview

HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons.
Synonyms

T1; HLADP; HLASB; HLA-DP1A; HLA-DPA1; HLA class II histocompatibility antigen, DP alpha 1 chain; DP(W3); DP(W4); MHC class II DPA; HLA-SB alpha chain; OTTHUMP00000029066; MHC class II antigen; MHC class II DP3-alpha; Primed lymphocyte test-4; MHC class IIPA1 antigen; HLA class II histocompatibility antigen, DP alpha chain;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Homo sapiens (Human)
Human
Zebrafish

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HLA-DPA1-13816H	Recombinant Human HLA-DPA1, GST-tagged	E.coli	GST	32-224a.a.	$319 / 25ug
Human	HLA-DPA1-4840H	Recombinant Human HLA-DPA1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HLA-DPA1-5506HCL	Recombinant Human HLA 293 Cell Lysate	HEK293	N/A		Inquiry
Human	HLA-DPA1-5290H	Recombinant Human HLA-DPA1 protein, His-tagged	E.coli	His	29-222aa	Inquiry
Human	HLA-DPA1-3427H	Recombinant Human HLA-DPA1 protein, His-tagged	E.coli	His	32-224 aa	$319 / 25ug
Human	HLA-DPA1-3582HF	Recombinant Full Length Human HLA-DPA1 Protein, GST-tagged	In Vitro Cell Free System	GST	260 amino acids	Inquiry
Homo sapiens (Human)	RFL26724HF	Recombinant Full Length Human Hla Class Ii Histocompatibility Antigen, Dp Alpha 1 Chain(Hla-Dpa1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (29-260)	Inquiry
Zebrafish	HLA-DPA1-5442Z	Recombinant Zebrafish HLA-DPA1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
HLA-DPA1 Related Articles

HLA-DPA1 involved in several pathways and played different roles in them. We selected most pathways HLA-DPA1 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phagosome	CTSSA;CD209C;H2-Q10;CTSLA;HLA-A;ATP6V1E1B;H2-AB1;Pla2r1;ITGB3
Cell adhesion molecules (CAMs)	NRCAMA;PVRL3;Itgam&Itgb2;CD40LG;Siglec1;F11R.1;HLA-DOB;BMA2;NLGN3
Antigen processing and presentation	HLA-A;RFX5;KLRD1;HSPA1A;HSP90AA1;HLA-DQB1;KLRC4;PSME2;KLRC2
Intestinal i	ICOS;IL15RA;IL6;CXCL12A;CD86;CXCL12;CCR9A;HLA-DMA;HLA-DRB4
ne network for IgA production	HLA-DQB1;ICOS;HLA-DPA1;HLA-DMA;PIGR;MAP3K14;IL-15RA;LTBR;HLA-DMB
Type I diabetes mellitus	HLA-DQA2;HLA-F;HLA-DQA1;GAD1;GAD2;HLA-DPB1;Fasl;INS;HLA-G
Leishmaniasis	ITGAM;FCGR4;HLA-DQB1;MAPK13;FCGR2C;HLA-DRB5;ITGB1;ITGB2L;TRAF6
Toxoplasmosis	PIK3CD;ITGA6;HLA-DRB1;Toxoplasma Gondii Major Surface Antigen P30;TAB2;HLA-DQA2;TGFB1;STAT1;SOCS1
Staphylococcus aureus infection	C2;FPR1;ITGAL;HLA-DRB4;C1QA;C1QC;HLA-DRB3;C1RA;C5
Tuberculosis	Ifna15;ITGAM;IFNA21;MAPK3;RFX5;HLA-DMA;RFXANK;IFNA4;PMAP-36
Influenza A	Ccl12;IL1B;IFNA17;IRF3;MAPK12;IFNAR2;RAE1;STAT1;PRKCB
HTLV-I infection	TGFBR1;CANX;CD40;TNFRSF1A;TBP;KAT2B;SFPI1;CCND1;TGFBR2
Herpes simplex infection	HLA-B;H2-Q10;FADD;CRFB2;SRSF7;IFNA12;SRSF5B;FOS;LTA
Epstein-Barr virus infection	HSPA1A;POLR3E;MAPK10;PRKACA;PSMD13;PSMD3;IKBKG;PSMC6;SHFM1
Asthma	MS4A2;HLA-DRB3;CD40;H2-AA;H2-AB1;HLA-DPA1;FCER1A;HLA-DRB4;IL4
Autoi	IFNA12;HLA-DQA2;Ifna15;FAS;TSHR;IFNA14;TG;IL5;IFNA6
ne thyroid disease	CD40;IFNA21;HLA-DPA1;HLA-DRB3;HLA-F;IFNA17;CD28;HLA-DQA1;HLA-DRB4
Inflammatory bowel disease (IBD)	STAT6;STAT4;Il4ra;IL23R;TGFB3;NFKB1;HLA-DOB;HLA-DQA2;IL1A
Systemic lupus erythematosus	TRIM21;SNRPB;GM14478;H2AFV;TNF;C2;HIST1H2AM;HLA-DRB5;HIST1H4C
Rheumatoid arthritis	ATP6V0A2;MMP1;Ccl12;HLA-DPA1;ATP6V0E;H2-AB1;ITGB2L;HLA-DOA;Il23a; Il12b
Allograft rejection	HLA-DMA;FASLG;H2-AA;HLA-E;HLA-DOA;HLA-C;IL5;CD40;CD28
Graft-versus-host disease	Il2;TNF;IL6;KIR3DL2;CD86;KLRD1;HLA-C;HLA-DRA;HLA-A
Viral myocarditis	ACTB;ACTG1;HLA-DRA;RAC3;EIF4G3;ABL2;FYN;HLA-DMA;SGCG

HLA-DPA1 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DPA1 itself. We selected most functions HLA-DPA1 had, and list some proteins which have the same functions with HLA-DPA1. You can find most of the proteins on our site.

Function	Related Protein
MHC class II receptor activity	HLA-DRB4;HLA-DOA;HLA-DQB2;HLA-DPA1;HLA-DRA;HLA-DRB3;HLA-DQB1;HLA-DQA2;HLA-DQA1
peptide antigen binding	MHC1UJA;HLA-DRB1;MHC1ZKA;HLA-F;H2-Q10;MHC1UBA;TUBB3;HLA-A;MHC1UFA

HLA-DPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DPA1.

CD74; prfC; q7ard3_yerpe; iucD; q7chc4_yerpe

Gan, SJ; Ye, B; et al. Immune- and Ribosome-Related Genes were Associated with Systemic Vasculitis. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:96-101(2015).

Ollila, HM; Ravel, JM; et al. HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy. AMERICAN JOURNAL OF HUMAN GENETICS 96:136-146(2015).