Recombinant Human HLA-DPA1 Protein, GST-tagged

• Cat.No.: HLA-DPA1-4840H
• Product Overview: Human HLA-DPA1 full-length ORF ( AAH09956, 1 a.a. - 260 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: GST
• Protein Length: 1-260 a.a.
• Description: HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq
• Molecular Mass: 54.34 kDa
• AA Sequence: MRPEDRMFHIRAVILRALSLAFLLSLRGAGAIKADHVSTYAAFVQTHRPTGEFMFEFDEDEQFYVDLDKKETVWHLEEFGRAFSFEAQGGLANIAILNNNLNTLIQRSNHTQAANDPPEVTVFPKEPVELGQPNTLICHIDRFFPPVLNVTWLCNGEPVTEGVAESLFLPRTDYSFHKFHYLTFVPSAEDVYDCRVEHWGLDQPLLKHWEAQEPIQMPETTETVLCALGLVLGLVGIIVGTVLIIKSLRSGHDPRAQGPL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 [ Homo sapiens ]
• Official Symbol: HLA-DPA1
• Synonyms: HLA-DPA1; major histocompatibility complex, class II, DP alpha 1; HLA DP1A; HLA class II histocompatibility antigen, DP alpha 1 chain; MHC class II DPA1; HLA-SB alpha chain; MHC class II antigen; MHC class II DP3-alpha; Primed lymphocyte test-1; MHC class II HLA-DPA1 antigen; HLA class II histocompatibility antigen, DP alpha chain; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DP1A
• Gene ID: 3113
• mRNA Refseq: NM_001242524
• Protein Refseq: NP_001229453
• MIM: 142880
• UniProt ID: P20036