HLA-DQA1 Protein


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Official Full Name major histocompatibility complex, class II, DQ alpha 1
Background HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
Synonyms CD; GSE; DQ-A1; CELIAC1; HLA-DQA; FLJ27088; FLJ27328; MGC149527; HLA-DQA1; HLA class II histocompatibility antigen, DQ alpha 1 chain; HLA-DCA; DC-alpha; DC-1 alpha chain; MHC HLA-DQ alpha; MHC class II DQA1; MHC class II antigen; leucocyte antigen DQA1; MHC class II HLA-DQ-alpha-1; leukocyte antigen alpha chain; MHC class II surface glycoprotein; MHC class II HLA-D alpha glycoprotein; HLA class II histocompatibility antigen, DQ(W3) alpha chain
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DQA1-13815H Recombinant Human HLA-DQA1 protein, His-tagged E.coli His
    Human HLA-DQA1-5291H Recombinant Human HLA-DQA1 protein, His-tagged E.coli His
    Human HLA-DQA1-13819H Recombinant Human HLA-DQA1, GST-tagged E.coli GST
    Human HLA-DQA1-29328TH Recombinant Human HLA-DQA1 Wheat Germ N/A
    Human HLA-DQA1-4844H Recombinant Human HLA-DQA1 Protein, GST-tagged Wheat Germ GST
    Human HLA-DQA1-5284H Recombinant Human HLA-DQA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HLA-DQA1-5507HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
    Rhesus Macaque HLA-DQA1-2102R Recombinant Rhesus monkey HLA-DQA1 Protein, His-tagged Mammalian Cell His

    HLA-DQA1 involved in several pathways and played different roles in them. We selected most pathways HLA-DQA1 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) NRXN3; CD40; SDC3; BMA1; HLA-B; MHC2DAB; H2-AB1; H2-Q10; HLA-E; CTLA4
    Antigen processing and presentation CTSB; CD4; H2-Q10; KLRC1; KIR3DL2; KIR3DL1; CD8B; KIR2DL1; HLA-DRA; KIR2DL4
    Intestinal i CCL25; TNFRSF17; CCL27B; Icosl; BMA1; TNFSF13; CXCR4; CD28; HLA-DOA; CD40
    ne network for IgA production CXCL12A; CD28; CD80; Il2; HLA-DRB5; HLA-DQA1; MADCAM1; ITGA4; HLA-DMB; BLB2
    Type I diabetes mellitus HLA-E; HSPD1; GAD1; CD86; HLA-DRB5; FASLG; HLA-DQA1; IL12B; PRF1; IL1B
    Leishmaniasis NCF4; FCGR3; H2-AB1; ITGA4; HLA-DOA; MAPK3; FCGR3A; NCF1; TAB2; HLA-DPB1
    Toxoplasmosis LAMB1; HSPA2; PIK3CD; AKT2; HLA-DPB1; MAPK11; HLA-DPA1; PIK3CB; STAT1; Toxoplasma Gondii Profilin Family Protein
    Staphylococcus aureus infection FCAR; HLA-DOB; ITGAM; GM5077; FCGR3; C1S; FGG; FCGR3A; C1QA; CFB
    Tuberculosis ATP6V0A1; FCGR3A; HSPD1; CALM2; EP300; IFNA4; FCGR4; RAB7A; MYD88; LBP
    Influenza A RAF1; BLB1; HLA-DPA1; NXF3; SLC25A6; IFNA21; MAP2K4; IL12A; HSPA8; MAPK11
    Herpes simplex infection GTF2IRD1; CLOCKA; CYCS; PKZ; HLA-DQA2; HNRPKL; SOCS3; IFNB; IFNA7; EIF2AK2
    Epstein-Barr virus infection PSMD4; PRKACA; POLR2C; POLR2I; AKT2; HLA-DRB1; HLA-DQB1; HSPA8; CD19; PSMD6
    Autoi HLA-DPA1; IFNA13; IFNA5; HLA-DPB1; H2-Q10; CD40LG; IFNA17; HLA-DQB1; HLA-E; IFNA2
    ne thyroid disease HLA-DRB5; IL5; Fasl; IFNA16; HLA-DOA; FAS; Ifna15; HLA-DRB4; TPO; CD40
    Inflammatory bowel disease (IBD) GATA3; IL12A; Il23a; TLR2; HLA-DPB1; H2-AB1; SMAD2; IL5; FOXP3; RORA
    Systemic lupus erythematosus GRIN2B; HIST1H2BE; HLA-DMA; HIST1H3G; HLA-DQA1; HLA-DPA1; H3F3A; FCGR3; HIST1H4E; HIST1H2AD
    Rheumatoid arthritis TGFB3; TLR4; CXCL1; GM-CSF; HLA-DMB; ATP6V0A2; ATP6V0C; IL15; HLA-DOB; IFNG
    Allograft rejection IL4; HLA-DQB1; HLA-A; HLA-DRA; H2-AA; HLA-DOB; HLA-DMA; IFNG; HLA-DMB; IL10
    Graft-versus-host disease KIR3DL1; HLA-DQB1; HLA-DRB5; HLA-G; Fasl; KLRC1; FAS; HLA-DOA; IL1B; HLA-DQA2
    Viral myocarditis RAC3; HLA-DRA; HLA-DRB1; RAC1; CASP8; HLA-DOB; ABL2; H2-Q10; CD86; HLA-DRB5

    HLA-DQA1 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQA1 itself. We selected most functions HLA-DQA1 had, and list some proteins which have the same functions with HLA-DQA1. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II receptor activity HLA-DOA; HLA-DRB1; HLA-DRA; HLA-DQA1; KRT17; HLA-DRB4; HLA-DRB3; HLA-DQB2; HLA-DPA1; HLA-DQB1
    peptide antigen binding HLA-B; MHC1UXA2; TUBB3; HLA-G; MHC1ZHA; HLA-DQB1; HLA-A; HLA-DPB1; MAML1; MHC1ZKA

    HLA-DQA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQA1.

    HLA-DQB1; CD74; HCRT; CDK7; APLP1; TLE1; UNC119; q5ngv3_fratt; RIF1; SH3GL2; IKBKG

    Akoglu, G; Metin, A; et al. Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family. INTERNATIONAL JOURNAL OF DERMATOLOGY 54:174-178(2015).
    Lemin, AJ; Johnson, J; et al. A group-specific sequence-based typing approach for HLA-DQA1. INTERNATIONAL JOURNAL OF IMMUNOGENETICS 42:15-18(2015).

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