HLA-DQA1
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Official Full Name
major histocompatibility complex, class II, DQ alpha 1
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Overview
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. -
Synonyms
CD; GSE; DQ-A1; CELIAC1; HLA-DQA; FLJ27088; FLJ27328; MGC149527; HLA-DQA1; HLA class II histocompatibility antigen, DQ alpha 1 chain; HLA-DCA; DC-alpha; DC-1 alpha chain; MHC HLA-DQ alpha; MHC class II DQA1; MHC class II antigen; leucocyte antigen DQA1; MHC class II HLA-DQ-alpha-1; leukocyte antigen alpha chain; MHC class II surface glycoprotein; MHC class II HLA-D alpha glycoprotein; HLA class II histocompatibility antigen, DQ(W3) alpha chain;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- HLA-DQA1 Related Articles
- HLA-DQA1 Related Gene Family
HLA-DQA1 involved in several pathways and played different roles in them. We selected most pathways HLA-DQA1 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | ATP6V0E1;CTSSB.1;cgr2b;ATP6V1G1;ATP6V1D;PIKFYVE;MHC2A;CALRL2;TUBA1L2 |
| Cell adhesion molecules (CAMs) | CLDN10;CLDN6;HLA-DQA2;CDH1;SDC1;VCAN;NFASC;BMA1;PVRL1B |
| Antigen processing and presentation | NFYB;RFXAP;KLRC2;HSPA1L;H2-Q10;HLA-C;HLA-B;HLA-G;HSPA2 |
| Intestinal i | HLA-DRB1;LTBR;TNFRSF13B;H2-AA;HLA-DPB1;CCR10;MHC2DCB;BMA2;BLB1 |
| ne network for IgA production | CD40LG;CCL27B;HLA-DMA;IL6;CXCR4;Icosl;CXCL12B;TNFSF13;HLA-DOA |
| Type I diabetes mellitus | GAD2;HSPD1;FASLG;HLA-DPA1;FAS;TNF;HLA-DOB;HLA-DRB4;HLA-F |
| Leishmaniasis | ITGAM;IRAK1;TLR4;IFNGR2;HLA-DMB;RELA;IFNG;HLA-DOA;ELK1 |
| Toxoplasmosis | LAMA4;GNAO1;SOCS1;AKT2;HLA-DRB3;HLA-DRA;LDLR;STAT1;MAP2K6 |
| Staphylococcus aureus infection | FCGR3;ITGB2L;HLA-DMA;HLA-DOB;PTAFR;HLA-DQA1;HLA-DRB5;HLA-DQA2;FCGR1 |
| Tuberculosis | CAMK2A;RFXAP;IFNA8;IFNB1;AKT2;CLEC4M;IL10RA;CARD9;FCGR3B |
| Influenza A | IFNA14;NXT2;PIK3CA;IFNA2;IL8L2;MAP2K1;IFNA10;MAPK1;MAPK8 |
| HTLV-I infection | POLD1;MRAS;TGFBR2;CALR;SLC25A4;FZD10;HLA-DMB;HLA-DRB4;POLE2 |
| Herpes simplex infection | PVRL1B;SRSF5A;ARNTL;TRAF6;CLOCK;PPP1CB;TRP53;MCRS1;CD74 |
| Epstein-Barr virus infection | POLR2F;POLR3GL;POLR3F;TRAF6;PIK3CA;HDAC1;TBP;SND1;HLA-DQB1 |
| Asthma | CD40LG;HLA-DQA1;EPX;HLA-DRB5;HLA-DPA1;HLA-DOB;HLA-DMA;IL9;H2-AB1 |
| Autoi | TSHR;H2-AA;GZMB;IFNA10;HLA-DQA1;HLA-DRB1;HLA-B;HLA-F;PRF1 |
| ne thyroid disease | CD80;IFNA2;IFNA17;HLA-DPA1;IFNA4;HLA-DQA1;IFNA14;HLA-DMB;TSHR |
| Inflammatory bowel disease (IBD) | TLR5;IL21R;HLA-DMA;Il2;IL17A;STAT4;HLA-DOB;FOXP3;STAT3 |
| Systemic lupus erythematosus | HIST1H4M;HIST1H2AI;HIST1H2AB;HLA-DQB1;HLA-DMB;HLA-DPA1;HIST1H2AL;HIST1H2AG;GM14477 |
| Rheumatoid arthritis | HLA-DOB;CD80;TGFB2;ATP6AP1;H2-AA;ATP6V1E1;TLR2;ATP6V0D2;ATP6V0D1 |
| Allograft rejection | H2-Q10;IL4;HLA-DQB1;CD86;HLA-A;FAS;HLA-DRB5;HLA-E;HLA-DPB1 |
| Graft-versus-host disease | HLA-DRB4;FASLG;HLA-DPA1;H2-AB1;HLA-G;HLA-B;IFNG;IL1A;HLA-E |
| Viral myocarditis | HLA-B;CAV1;ACTB;ABL2;HLA-DPB1;EIF4G3;HLA-DMA;HLA-G;HLA-C |
HLA-DQA1 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQA1 itself. We selected most functions HLA-DQA1 had, and list some proteins which have the same functions with HLA-DQA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MHC class II receptor activity | HLA-DOB;HLA-DQB2;HLA-DRA;HLA-DRB3;HLA-DRB4;HLA-DQA1;HLA-DOA;HLA-DRB1;KRT17 |
| peptide antigen binding | HLA-DPA1;HLA-DQA1;HLA-C;HLA-DRB1;MHC1UFA;DHCR24;HLA-DRB5;H2-AA;MHC1UHA |
HLA-DQA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQA1.
HLA-DQB1; CD74; HCRT; CDK7; APLP1; TLE1; UNC119; q5ngv3_fratt; RIF1; SH3GL2; IKBKG
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