hmga1
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  • Official Full Name
  • high mobility group AT-hook 1
  • Synonyms
  • HMGA1; high mobility group AT-hook 1; high mobility group (nonhistone chromosomal) protein isoforms I and Y , HMGIY; high mobility group protein HMG-I/HMG-Y; HMG-I(Y); high mobility group protein R; high mobility group protein A1; nonhistone chromosomal h
Cat.#:HMGA1-3597HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGA1, His-tagged
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Cat.#:HMGA1-4435HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGA1 Protein, His-tagged
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Cat.#:HMGA1-4437HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGA1 Protein, His-tagged
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Cat.#:HMGA1-4863HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HMGA1 Protein, GST-tagged
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Cat.#:Hmga1-174MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hmga1 Protein, His-tagged
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Cat.#:Hmga1-175RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hmga1 Protein, His-tagged
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Cat.#:HMGA1-7725MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HMGA1 Protein
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Cat.#:HMGA1-2865RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HMGA1 Protein
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Cat.#:HMGA1-2107RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HMGA1 Protein, His-tagged
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Cat.#:HMGA1-5939CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HMGA1
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Cat.#:HMGA1-5479HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HMGA1 293 Cell Lysate
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Cat.#:HMGA1-5480HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HMGA1 293 Cell Lysate
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Involved Pathway

HMGA1 involved in several pathways and played different roles in them. We selected most pathways HMGA1 participated on our site, such as 2-LTR circle formation, APOBEC3G mediated resistance to HIV-1 infection, Adipogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
2-LTR circle formation
HMGA1; BANF1; PSIP1; gag
APOBEC3G mediated resistance to HIV-1 infection
BANF1; PSIP1; APOBEC3G; gag; HMGA1; PPIA
Adipogenesis
DDIT3; CEBPB; RETN; AGT; KLF7A; SMAD3B; NR2F1; EPAS1B; EGR2; BMP1
Autointegration results in viral DNA circles
PSIP1; gag; HMGA1; BANF1
Cellular Senescence
RING1; SUZ12A; CBX4; HIST1H1C; POT1; CDKN2D; EED; TERF2IP; CDKN2B; HIST1H1D
Cellular responses to stress
ATG101; HIF1AN; DYNLL2B; HIST1H1B; EGLN2; CDKN2C; HSBP1; SUZ12A; HMGA1; CDK6
DNA Damage/Telomere Stress Induced Senescence
HTATIP; TERF2IP; HMGA1B; HIRA; POT1; HMGA1-RS1; TINF2; HIST1H1D; TERF2; POT1A
Disease
FDX1; MMAA; LTF; CHMP4B; VPS37A; SFTPB; KPNA5; MTRR; NUPL2; AP2M1

Protein Function

HMGA1 has several biochemical functions, for example, 5-deoxyribose-5-phosphate lyase activity, AT DNA binding, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGA1 itself. We selected most functions HMGA1 had, and list some proteins which have the same functions with HMGA1. You can find most of the proteins on our site.
Function
Related Protein
Function 5-deoxyribose-5-phosphate lyase activity
Related Protein HMGA2; HMGA1-RS1; HMGA1; XRCC6
Function AT DNA binding
Related Protein HMGA1; MEF2C; HMGA2; POU3F4; CRIP1
Function DNA binding
Related Protein TBX22; MEIS4.1A; ZFP641; CERS4; GATA4; CREBZF; TTC4; ZBTB16A; HIST2H2L; IKZF1
Function DNA-(apurinic or apyrimidinic site) lyase activity
Related Protein HMGA1A; APLF; APEX2; ALKBH1; NEIL1; HMGA1-RS1; NEIL2; RPS3; HMGA2; NEIL3
Function chromatin binding
Related Protein ZGLP1; PSIP1; FOXC1A; SIRT6; APBB1; TRIM37; HCFC1; EWSR1A; TOP1; GATA5
Function enzyme binding
Related Protein NR5A1; LDB1; BLZF1; LAMB1; EHHADH; SIRT3; HSPA6; BIRC5; HYAL2; P4HB
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein PPARGC1B; SMARCD3; ACTN1; PUS1; PPARGC1A; SLC30A9; MED14; DCAF6; NCOA3; SRA1
Function peroxisome proliferator activated receptor binding
Related Protein EP300; NR0B2; PPARGC1A; IKBKG; MED1; HMGA1; CREBBP; NFATC4; HMGA1-RS1; ASXL2
Function protein binding
Related Protein MDM2; CRYGD; AKAP9; KRT38; OLA1; RRAGA; FCHO2; EPB41B; SOCS6; KLRC4-KLRK1
Function retinoic acid receptor binding
Related Protein CNOT1; RXRA; SNW1; PRMT2; CTBP2; ACTN4; HMGA1; PRAMEF2; LRIF1; PRAME
Function retinoid X receptor binding
Related Protein RARB; HMGA1; FUS; HMGA1-RS1; VDR; NR1H2; NSD1; NCOA1; NR0B2; NR4A2
Function transcription factor activity, sequence-specific DNA binding
Related Protein OTX1B; FOXD1L; ZSCAN2; MYF6; MAFBA; IRF4; ZFP42; KLF7; ARNTL2; FOXP1A
Function transcription factor binding
Related Protein HOXA7; ESR1; CREBBP; NLRP3; UBE2I; PPP1R13BB; NR0B1; HIF1A; PAX6; PPID
Function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein FOXH1; PBX3; REL; SIX3; NFKB1; HCFC1; POU4F1; RELA; MEOX2; TARDBP

Interacting Protein

HMGA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGA1.
SP1; CEBPB; il2ra_human_gene; il2ra_human_+3317/+3478_dna-probe; Stag2; HSP90AB1; HTT; EWSR1; Kifc5b; ssdna_dadts

HMGA1 Related Articles

Chieffi, P; Chieffi, S; et al. Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumors: An overview. JOURNAL OF CELLULAR PHYSIOLOGY 228:1641-1646(2013).
Chieffi, P; et al. New Prognostic Markers and Potential Therapeutic Targets in Human Testicular Germ Cell Tumors. CURRENT MEDICINAL CHEMISTRY 18:5033-5040(2011).