HMGCS2
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Official Full Name
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -
Synonyms
HMGCS2;3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial);3 hydroxy 3 methylglutaryl Coenzyme A synthase 2 (mitochondrial);hydroxymethylglutaryl-CoA synthase, mitochondrial;HMG-CoA synthase;3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- T7
- Non
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
HMGCS2 involved in several pathways and played different roles in them. We selected most pathways HMGCS2 participated on our site, such as Synthesis and degradation of ketone bodies,Valine, leucine and isoleucine degradation,Butanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGCS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Butanoate metabolism | ACSM2,GAD1B,ACADS,Acsm2a,GAD1,OXCT1,ACSM4,ECHS1,HMGCL,EHHADH |
| Synthesis and degradation of ketone bodies | OXCT2B,OXCT2,HMGCL,HMGCLL1,OXCT1A,OXCT1B,OXCT2A,BDH2,ACAT2,HMGCS1 |
| Valine, leucine and isoleucine degradation | AUH,PCCB,OXCT2,HADHA,AOX4,ALDH9A1A.1,AOX1,HADH,BCKDHA,ALDH7A1 |
| Metabolic pathways | FUT8A,ATP6V0CA,ATP5O,B4GALNT1,UQCRB,DHRS13L1,SMPD1,PKM2,HYAL3,MAOB |
| Terpenoid backbone biosynthesis | DHDDS,MVK,FDPS,HMGCS1,ACAT1,ACAT2,HMGCR,MVD,HMGCRB,PDSS2 |
| PPAR signaling pathway | MMP1,Scd1,UBC,ANGPTL4,PPARAB,CYP7A1A,ADIPOQ,FABP3,PPARD,PLIN1 |
Protein Function
HMGCS2 has several biochemical functions, for example, hydroxymethylglutaryl-CoA synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGCS2 itself. We selected most functions HMGCS2 had, and list some proteins which have the same functions with HMGCS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydroxymethylglutaryl-CoA synthase activity | HMGCS1 |
Interacting Protein
HMGCS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGCS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGCS2.
YWHAZ
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References
Reviews
We tested the enzyme and found that it worked. We were able to observe optimal results at the protein concentration of 1 µg/well.
