HMGCS2

  • Official Full Name

    3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
  • Synonyms

    HMGCS2;3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial);3 hydroxy 3 methylglutaryl Coenzyme A synthase 2 (mitochondrial);hydroxymethylglutaryl-CoA synthase, mitochondrial;HMG-CoA synthase;3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • E. coli
  • In Vitro Cell Free System
  • His
  • GST
  • T7
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
HMGCS2-134H Recombinant Human HMGCS2 Protein, His-tagged E.coli Human His
HMGCS2-4877H Recombinant Human HMGCS2 Protein, GST-tagged Wheat Germ Human GST
HMGCS2-7735M Recombinant Mouse HMGCS2 Protein Mammalian Cells Mouse His
Hmgcs2-8171M Recombinant Mouse Hmgcs2 protein, His & T7-tagged E.coli Mouse His&T7 Met1~Tyr167
HMGCS2-804HCL Recombinant Human HMGCS2 cell lysate Human Non
HMGCS2-1081H Recombinant Human HMGCS2 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
HMGCS2-1081H-B Recombinant Human HMGCS2 Protein Pre-coupled Magnetic Beads HEK293 Human
Hmgcs2-1137M Recombinant Mouse Hmgcs2 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
HMGCS2-135H Recombinant Human HMGCS2 Protein T91A Mutant, His tagged E. coli Human His
HMGCS2-136H Recombinant Human HMGCS2 Protein T91D Mutant, His tagged E. coli Human His
HMGCS2-1766HFL Recombinant Full Length Human HMGCS2 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
HMGCS2-3611H Recombinant Human HMGCS2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
HMGCS2-3649HF Recombinant Full Length Human HMGCS2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 508 amino acids
HMGCS2-4242M Recombinant Mouse HMGCS2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
HMGCS2-4242M-B Recombinant Mouse HMGCS2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    HMGCS2 involved in several pathways and played different roles in them. We selected most pathways HMGCS2 participated on our site, such as Synthesis and degradation of ketone bodies,Valine, leucine and isoleucine degradation,Butanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGCS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways NANSA,HADHA,ACOT1,NDUFB7,P4HA1A,OLAH,PTGES3B,IDO2,HAO1,HYKK
    Synthesis and degradation of ketone bodies OXCT2,BDH1,OXCT2A,OXCT1B,HMGCS1,ACAT2,OXCT1A,ACAT1,HMGCLL1,OXCT2B
    Butanoate metabolism OXCT2,HADHA,BDH2,HMGCL,HMGCLL1,ABAT,OXCT1,OXCT2A,ACAT1,DHRS13L1
    PPAR signaling pathway ACSL4A,FABP6,FABP7,CD36,PCK2,APOA1,PDPK1,SCD5,UCP1,APOA1A
    Valine, leucine and isoleucine degradation ALDH2.2,DLDH,ALDH2.1,OXCT2B,ACAT1,AOX2P,HADH,OXCT1B,HIBADHB,HIBCH
    Terpenoid backbone biosynthesis PDSS2,HMGCRB,NUS1,MVD,PDSS1,HMGCR,HMGCRA,ZMPSTE24,FNTB,IDI2

    Protein Function

    HMGCS2 has several biochemical functions, for example, hydroxymethylglutaryl-CoA synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGCS2 itself. We selected most functions HMGCS2 had, and list some proteins which have the same functions with HMGCS2. You can find most of the proteins on our site.

    Function Related Protein
    hydroxymethylglutaryl-CoA synthase activity HMGCS1

    Interacting Protein

    HMGCS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGCS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGCS2.

    YWHAZ

    Resources

    References

    Reviews

    Reviews
    01/25/2025

    We tested the enzyme and found that it worked. We were able to observe optimal results at the protein concentration of 1 µg/well.

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