Recombinant Human HMGCS2 cell lysate

• Cat.No.: HMGCS2-804HCL

Specification

• Species: Human
• Tag: Non
• Description: Mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase (HMGCS2; EC 2.3.3.10) mediates the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for brain, heart, kidney, and other organs during times of carbohydrate deprivation such as fasting (Robinson and Williamson, 1980 [PubMed 6986618]). Also see cytoplasmic HMG-CoA synthase (HMGCS1; MIM 142940), which mediates an early step in cholesterol synthesis.
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) [ Homo sapiens ]
• Official Symbol: HMGCS2
• Synonyms: HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); 3 hydroxy 3 methylglutaryl Coenzyme A synthase 2 (mitochondrial); hydroxymethylglutaryl-CoA synthase, mitochondrial; HMG-CoA synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
• Gene ID: 3158
• mRNA Refseq: NM_001166107
• Protein Refseq: NP_001159579
• MIM: 600234
• UniProt ID: P54868
• Chromosome Location: 1p13-p12
• Pathway: Butanoate metabolism, organism-specific biosystem; Butanoate metabolism, conserved biosystem; C5 isoprenoid biosynthesis, mevalonate pathway, organism-specific biosystem; C5 isoprenoid biosynthesis, mevalonate pathway, conserved biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Ketone body metabolism, organism-specific biosystem; Metabolic pathways, organism-specific biosystem
• Function: hydroxymethylglutaryl-CoA synthase activity; transferase activity