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Official Full Name hydroxysteroid (17-beta) dehydrogenase 2
Background Estradiol 17-beta-dehydrogenase 2 is an enzyme that in humans is encoded by the HSD17B2 gene.
Synonyms HSD17B2; hydroxysteroid (17-beta) dehydrogenase 2; estradiol 17-beta-dehydrogenase 2; HSD17; SDR9C2; short chain dehydrogenase/reductase family 9C; member 2; 17 beta HSD 2; 20 alpha HSD; 20 alpha hydroxysteroid dehydrogenase; E2DH; Microsomal 17 beta hydroxysteroid dehydrogenase; Testosterone 17 beta dehydrogenase; 20-alpha-HSD; 17-beta-HSD 2; OTTHUMP00000174979; testosterone 17-beta-dehydrogenase; 20 alpha-hydroxysteroid dehydrogenase; 17-beta-hydroxysteroid dehydrogenase type 2; microsomal 17-beta-hydroxysteroid dehydrogenase; short chain dehydrogenase/reductase family 9C, member 2; EDH17B2
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSD17B2-1364H Recombinant Human HSD17B2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HSD17B2-206H Recombinant Human HSD17B2, GST-tagged Wheat Germ GST
    Human HSD17B2-5375HCL Recombinant Human HSD17B2 293 Cell Lysate HEK293 N/A
    Mouse Hsd17b2-1178M Recombinant Mouse Hsd17b2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse HSD17B2-7877M Recombinant Mouse HSD17B2 Protein Mammalian Cell His
    Rat HSD17B2-2926R Recombinant Rat HSD17B2 Protein Mammalian Cell His
    Cynomolgus Monkey HSD17B2-600C Recombinant Cynomolgus HSD17B2 Protein, His-tagged Mammalian Cell His
    Zebrafish HSD17B2-3728Z Recombinant Zebrafish HSD17B2 Mammalian Cell His

    hsd17b2 involved in several pathways and played different roles in them. We selected most pathways hsd17b2 participated on our site, such as Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with hsd17b2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Steroid hormone biosynthesis CYP2D10; CYP3A25; HSD11B1; HSD3B4; HSD17B7; UGT1A4; CYP2C39; CYP2C70; CYP7B1; SRD5A3
    Metabolic pathways HAO2; cysH; DPYS; PRODH2; MVDA; FAXDC2; NMNAT1; MT-ND4; DHODH; ASAH1
    Ovarian steroidogenesis PRKACA; LHB; IGF1; BMP15; INSR; PLA2G4F; HSD3B2; HSD3B6; FSHR; FSHB

    hsd17b2 has several biochemical functions, for example, 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity, estradiol 17-beta-dehydrogenase activity, testosterone dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by hsd17b2 itself. We selected most functions hsd17b2 had, and list some proteins which have the same functions with hsd17b2. You can find most of the proteins on our site.

    Function Related Protein
    17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity HSD17B2; AKR1C6
    estradiol 17-beta-dehydrogenase activity RDH8A; AKR1B15; HSD17B14; HSD17B11; H2-KE6; HSD17B12; HSD17B8; RDH8B; HSD17B2; HSD17B1
    testosterone dehydrogenase (NAD+) activity HSD17B6; AKR1C3; HSD17B2; HSD17B1; HSD17B8; DHRS9; H2-KE6

    hsd17b2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hsd17b2 here. Most of them are supplied by our site. Hope this information will be useful for your research of hsd17b2.

    Cheng, YH; Imir, A; et al. SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium. BIOLOGY OF REPRODUCTION 75:605-614(2006).

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