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IDH3G

Official Full Name

isocitrate dehydrogenase 3 (NAD+) gamma
Overview

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined.
Synonyms

IDH3G; isocitrate dehydrogenase 3 (NAD+) gamma; isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial; mitochondrial; H IDHG; H-IDHG; IDH gamma; IDH3G_HUMAN; Isocitrate dehydrogenase [NAD] subunit gamma; Isocitric dehydrogenase; Isocitric dehydrogenase subunit gamma; NAD (H) specific isocitrate dehydrogenase gamma subunit; NAD(+) specific ICDH; NAD(+)-specific ICDH; NAD(+)-specific ICDH subunit gamma; NAD+ specific ICDH; OTTHUMP00000025984; OTTHUMP00000025985; OTTHUMP00000025987; OTTHUMP00000025988; OTTHUMP00000214764; IDH-gamma; NAD+-specific ICDH; NAD (H)-specific isocitrate dehydrogenase gamma subunit; isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, gamma subunit;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
SUMO
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IDH3G-1324H	Recombinant Human Isocitrate Dehydrogenase 3 (NAD+) Gamma, His-tagged	E.coli	His		Inquiry
Human	IDH3G-28927TH	Recombinant Human IDH3G, His-tagged	E.coli	His	354 amino acids	Inquiry
Human	IDH3G-28079TH	Recombinant Human IDH3G	Wheat Germ	N/A	393 amino acids	Inquiry
Human	IDH3G-5302HCL	Recombinant Human IDH3G 293 Cell Lysate	HEK293	N/A		Inquiry
Human	IDH3G-5303HCL	Recombinant Human IDH3G 293 Cell Lysate	HEK293	N/A		Inquiry
Human	IDH3G-252HF	Recombinant Full Length Human IDH3G Protein	In Vitro Cell Free System		393 amino acids	Inquiry
Human	IDH3G-3064H	Recombinant Human IDH3G protein, His-SUMO-tagged	E.coli	His-SUMO	40-393aa	Inquiry
Mouse	IDH3G-7988M	Recombinant Mouse IDH3G Protein	Mammalian Cell	His		Inquiry
Mouse	IDH3G-4412M	Recombinant Mouse IDH3G Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	IDH3G-4412M-B	Recombinant Mouse IDH3G Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	IDH3G-2471Z	Recombinant Zebrafish IDH3G	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
IDH3G Related Articles

IDH3G involved in several pathways and played different roles in them. We selected most pathways IDH3G participated on our site, such as Citrate cycle (TCA cycle), Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH3G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Citrate cycle (TCA cycle)	ACLY;IDH3A;PCXB;MDH1;SDHC;FH;IDH2;SDHDA;IDH3B
Metabolic pathways	UGT2A3;PLD3;UQCRFS1;B3GNT3;MAOA;ZNF408;PYCR1B;AMY2A;NDUFB8
Carbon metabolism	SUCLA2;TALDO1;ECHS1;ALDOAA;GLUD1B;CAT;PDHA1;ENO1B;PKM2
-Oxocarboxylic acid metabolism	ACO1;IDH3G;IDH3B;ACO2;GPT2;GPT;AADAT;BCAT1;GOT2
Biosynthesis of amino acids	GOT2B;PGAM1;SHMT1;MAT2AA;CPS1;TALDO1;ARG2;ALDOC;GOT1

IDH3G has several biochemical functions, for example, ATP binding, NAD binding, isocitrate dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH3G itself. We selected most functions IDH3G had, and list some proteins which have the same functions with IDH3G. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	ABCA9;TYK2;HSP90AB1;STK25A;MAP3K11;MAPK9;SIK3;TESK2;RAD51C
NAD binding	GPD1;IDH2;CTBP2L;PARP1;GPD1A;HIBADHB;AOX4;GRHPR;IDH1
isocitrate dehydrogenase (NAD+) activity	IDH3A;IDH3B;IDH3G
magnesium ion binding	FDXACB1;MAST4;PPM1BB;PTEN;FOXK2;CIB3;PIF1;FARS2;NCS1

IDH3G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH3G here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH3G.

IDH3A; adp; MYC

Bzymek, KP; Colman, RF; et al. Role of alpha-Asp(181), beta-Asp(192), and gamma-Asp(190) in the distinctive subunits of human NAD-specific isocitrate dehydrogenase. BIOCHEMISTRY 46:5391-5397(2007).

Dal Monego, S; Colitti, M; et al. Evaluation of gene expression profiles of pig skeletal muscle in response to energy content of the diets using human microarrays. ITALIAN JOURNAL OF ANIMAL SCIENCE 6:45-59(2007).