igf2

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igf2

Official Full Name Insulin-like Growth Factor-II
Background This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms IGF2; IGF-II; PP9974; C11orf43; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; insulin-like growth factor type 2; GF2; FLJ22066; FLJ44734; insulin-like growth factor 2 (somatomedin A); C11orf43, chromosome 11 open reading frame 43; insulin-like growth factor II; somatomedin-A; insulin-like growth factor type 2; PP9974
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rabbit
    • Rat
    • Salmon/Trout
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Yeast
    • Tag :
    • Avi
    • Fc
    • GST
    • His
    • NusA
    • T7
    • human
    • IgG1
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IGF2-1220H Recombinant Human IGF2 Protein (30-180 aa), GST-tagged E.coli GST
    Human IGF2-385H Recombinant Human GF2 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IGF2-037H Recombinant Human IGF2 Protein HEK293 N/A
    Human IGF2-156H Human Insulin-like growth Factor-II (rDNA derived) Reference standard E.coli N/A
    Human IGF2-212H Recombinant Human IGF2, StrepII-tagged Human Cell Strep II
    Human IGF2-215H Recombinant Human IGF2 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
    Human IGF2-28319TH Recombinant Human IGF2 E.coli N/A
    Human IGF2-29116TH Native Human IGF2 N/A
    Human IGF2-2H Recombinant Human IGF2 yeast N/A
    Human IGF2-371H Recombinant Human IGF2 insulin-like growth factor 2 (somatomedin A) E.coli N/A
    Human IGF2-373H Recombinant Human Insulin-like Growth Factor 2 (Somatomedin A) HEK293 N/A
    Human IGF2-450H Recombinant Human Insulin-like Growth Factor 2 (Somatomedin A) E.coli N/A
    Human IGF2-457H Recombinant Human Insulin-like Growth Factor 2 (Somatomedin A) Yeast N/A
    Human IGF2-462H Recombinant Human IGF2, 1-104 aa E.coli N/A
    Human IGF2-476H Recombinant Human IGF2 Protein Yeast N/A
    Human IGF2-486H Recombinant Human IGF2, 25-91 aa E.coli N/A
    Human IGF2-5266HCL Recombinant Human IGF2 293 Cell Lysate HEK293 N/A
    Human IGF2-5430H Recombinant Human Insulin-Like Growth Factor 2 (somatomedin A) E.coli N/A
    Human IGF2-5431H Recombinant Human Insulin-Like Growth Factor 2 (somatomedin A) E.coli N/A
    Human IGF2-570H Recombinant Human IGF2, His & NusA tagged E.coli His/NusA
    Human IGF2-609H Recombinant Human Insulin-like Growth Factor 2 (somatomedin A) N/A
    Human IGF2-620H Recombinant Human IGF2 protein E.coli N/A
    Human IGF2-621H Native Human Insulin-Like Growth Factor 2 (somatomedin A) E.coli N/A
    Human IGF2-692H Recombinant Human Insulin-Like Growth Factor 2 (somatomedin A) E.coli N/A
    Human IGF2-719H Recombinant Human IGF2 Protein, GST-His-tagged E.coli GST/His
    Human IGF2-816H Recombinant Human IGF2 protein, His & T7-tagged E.coli His/T7
    Mouse Igf2-736M Recombinant Mouse Insulin-Like Growth Factor 2 E.coli N/A
    Mouse IGF2-8065M Recombinant Mouse IGF2 Protein Mammalian Cell His
    Mouse Igf2-817M Recombinant Mouse Igf2 protein, His-tagged E.coli His
    Rat IGF2-3005R Recombinant Rat IGF2 Protein Mammalian Cell His
    Rat Igf2-818R Recombinant Rat Igf2 protein, His-tagged E.coli His
    Chicken IGF2-2228C Recombinant Chicken IGF2 Mammalian Cell His
    Chicken IGF2–323C Recombinant Chicken Insulin-Like Growth Factor 2 (Somatomedin A) E.coli N/A
    Rabbit IGF2-819R Recombinant Rabbit IGF2 protein, His & T7-tagged E.coli His/T7
    Salmon/Trout igf2-447S Recombinant Salmo/Trout Insulin-like Growth Factor II E.coli N/A

    igf2 involved in several pathways and played different roles in them. We selected most pathways igf2 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with igf2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteoglycans in cancer PDCD4; PTCH1; PRKCA; PAK1; TLR2; RPS6KB1; WNT9A; TGFB1; CAMK2A; IGF2

    igf2 has several biochemical functions, for example, growth factor activity, hormone activity, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by igf2 itself. We selected most functions igf2 had, and list some proteins which have the same functions with igf2. You can find most of the proteins on our site.

    Function Related Protein
    growth factor activity PROK1; GPI; CLEC11A; CD320; IL3; BMP15; GDF1; VHL; CXCL12; TGFB1
    hormone activity GNRH1; CRH; ADCYAP1A; EDN2; PRL7D1; SST2; POMCB; FNDC5B; BMP10; SST
    insulin receptor binding PTPN11; DOK3; DOK2; ENPP1; IGF1R; DOK5; FRS2B; DOK1B; DOK6; PTPN1
    insulin-like growth factor receptor binding IGF2B; GNAS; IGF2A; SOCS2; YWHAG; PIK3R1; YWHAH; INS; SHC1; Ren1
    protein binding TNK1; KIAA1109; FOXJ2; CHMP4B; EPS8L1; UXT; AGBL4; RPRD1A; TNK2; CCNG1
    protein serine/threonine kinase activator activity STK4; CALM3; PARP16; CAB39; STRADA; MAP2K2; ALS2; MAP2K1; IGF2; SPRY2
    receptor activator activity IGF2; PRKCE; PPARGC1B

    igf2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with igf2 here. Most of them are supplied by our site. Hope this information will be useful for your research of igf2.

    IGF2R; RBPMS

    Plymate, SR; Bhatt, RS; et al. Taxane Resistance in Prostate Cancer Mediated by AR-Independent GATA2 Regulation of IGF2. CANCER CELL 27:158-159(2015).
    Kang, Z; Yu, Y; et al. Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma. ONCOGENE 33:5697-5705(2014).

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